Stem Cell and Bioengineering Approaches for End-Stage Renal Disease: A Comprehensive Review [0.03%]
终末期肾病的干细胞和生物工程技术：全面综述
Yusuke Nishimura
Yusuke Nishimura
End-stage renal disease (ESRD) is a major global health burden, and current treatments, such as dialysis and kidney transplantation, remain constrained by donor shortages, procedure-related complications, and reduced long-term quality of li...
Chemotherapy resistance of urinary bladder cancer mediated by a Notch and Wnt co-regulatory module of stemness [0.03%]
Notch和Wnt协同调节模块介导的尿路上皮癌化疗耐药性研究
Li-Hsin Cheng,Che-Wei Hsu,Pei-Ming Yang et al.
Li-Hsin Cheng et al.
Despite breakthroughs in molecularly targeted and immune therapies, the prognosis for patients with urinary bladder cancer (UBC) has remained unsatisfactory over the past few decades. Understanding the molecular underpinnings of UBC treatme...
Profiling the secretome: maternal obesity impacts redox and adipogenic signaling during neonatal mesenchymal stem cell adipogenesis [0.03%]
分泌组特征分析：母体肥胖影响新生儿间充质干细胞向脂肪细胞分化的氧化应激和促脂生成信号
Sofía Bellalta,Erika Pinheiro-Machado,Paola Casanello et al.
Sofía Bellalta et al.
Recent studies evidence an altered bioenergetic profile and higher adipogenic commitment in the mesenchymal stem cells (MSC) from neonates of mothers with obesity. We hypothesize that these alterations may also affect the secretome of these...
Circadian Timing Optimizes Allo-HSCT to Prevent aGVHD: A Breakthrough in Chrono-Immunotherapy [0.03%]
优化异基因造血干细胞移植预防aGVHD的生物钟定时给药新策略——时间医学免疫学的新突破
Xiaguang Huang,Hening Xu,Yanru Xia et al.
Xiaguang Huang et al.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is widely regarded as the most potent curative cell therapy for a range of malignancies, particularly hematologic cancers. However, its clinical application remains significantl...
miR-124 orchestrates Epicardial-Mesenchymal-Transformation and Paracrine Cardiomyocyte Maturation in Epicardial-Specific tcf21-PKR1 knockout mice [0.03%]
MiR-124协调 epicardium-间充质转化和 epicardium特异性tcf21-pkr1敲除小鼠的心脏成纤维细胞旁分泌心肌细胞成熟作用
Himanshu Arora,Martina Vincenzi,Anais Audebrand et al.
Himanshu Arora et al.
Epicardial-to-mesenchymal transition (EMT) is essential for generating progenitor cells that shape cardiac development, but the molecular control of EMT and its paracrine effects on cardiomyocytes remain poorly elucidated. Here, we defined ...
Optogenetic activation of TGFβ signaling drives ligand-free chondrogenesis in hESC-derived MSCs [0.03%]
光遗传学激活TGFβ信号可在人胚胎干细胞来源的间充质干细胞中驱动无配体软骨发生
Jeongmin Lee,Gabsang Lee,Yohan Oh
Jeongmin Lee
Optogenetics holds great potential for diverse biological applications, including fundamental research, tissue engineering, and regenerative medicine, by enabling the precise spatial and temporal control of cellular signaling pathways. Tran...
Nicotinamide salvage is required for proliferation and sustaining self-renewal in undifferentiated embryonic stem cells [0.03%]
烟酸胺补救途径在维持小鼠胚胎干细胞的自我更新和促进增殖上是必需的
Mu-Jie Lu,Hsin-Ru Chan,Samiksha Deme et al.
Mu-Jie Lu et al.
Stem cells use oxidized nicotinamide adenine dinucleotide (NAD+) in distinct subcellular compartments to support self-renewal and to regulate chromatin. There is limited information, however, about the biosynthetic pathways that replenish i...
Catechin Promotes Osteogenic Differentiation via AMPK-mediated Autophagy Activation in Bone Marrow Mesenchymal Stem Cells [0.03%]
儿茶素通过AMPK介导的自噬激活促进骨髓间充质干细胞成骨分化
Haixia Liu,Ang Li,Jing Yue et al.
Haixia Liu et al.
Catechin (CH) exhibits protective effects on bone metabolism, although its underlying mechanism has remained incompletely understood. This study aimed to investigate the osteogenic-promoting effects of CH and the underlying molecular pathwa...
Valproic acid-expanded cord blood CD34+CD90+ cells are functionally distinct based on their origin [0.03%]
基于起源万古霉素扩增的脐带血CD34+CD90+细胞的功能特性不同
Al Rabee Kassis,Amudha Ganapathy,Amal Mechaal et al.
Al Rabee Kassis et al.
Hematopoietic stem cell (HSC) transplantation is a potentially curative option for patients with hematologic malignancies, but donor shortages impact graft availability. Umbilical cord blood (UCB) is a viable alternative source of HSC, howe...