CircVapa promotes the abnormal differentiation of small intestinal epithelial stem cells in diabetic state [0.03%]
CircVapa促进糖尿病状态下小肠上皮干细胞分化异常
Ti-Dong Shan,Wen-Jing Feng,Li Chen
Ti-Dong Shan
Diabetic enteropathy (DE) is a common complication of diabetes mellitus (DM), yet its underlying molecular mechanisms remain poorly understood. Emerging evidence suggests that abnormal differentiation of intestinal epithelial stem cells (IE...
Transforming Growth Factor beta-2 (TGFβ2) Drives Trabecular Meshwork Progenitor Cell Differentiation Through SMAD2/3 Signalling [0.03%]
转化生长因子β2(TGFβ2)通过SMAD2/3信号促进小梁网干细胞分化
Xiaochen Fan,Emine K Bilir,Olivia A Kingston et al.
Xiaochen Fan et al.
Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness, yet its underly mechanisms remain unclear. Elevated intraocular pressure (IOP), the only modifiable risk factor for POAG, arises from increased resistance to aqu...
Circular RNA circEGFR overexpression attenuates chemosensitivity and enhances cancer stemness via targeting IGF2BP2/SOX2 in breast cancer cells [0.03%]
circular RNA circEGFR过表达通过靶向IGF2BP2/SOX2减弱乳腺癌细胞的化疗敏感性并增强癌干细胞特性
Xinran Zhao,Jie Wen,Yijian Yao et al.
Xinran Zhao et al.
Breast cancer (BC) has a high incidence and mortality rate among women. Doxorubicin (DOX) is one of the standard chemotherapeutic drugs for BC. However, chemoresistance to DOX represents a major therapeutic obstacle, and its underlying mech...
Olena Zhulyn,Vanessa Donega
Olena Zhulyn
Compared to amphibians, fish, and reptiles, mammals have an impaired capacity to regenerate the brain, despite the presence of a neural stem cell pool. Here, we consider the biological significance of a stem cell source in the human brain b...
Mitochondrial transfer technologies with molecular insights into clinical applications [0.03%]
具有分子洞见的线粒体转移技术及其临床应用
Vahan Martirosian,Berney Peng,Michael A Teitell
Vahan Martirosian
Mitochondria are essential cell signaling, survival, and bioenergetic organelles that uniquely harbor a maternally inherited, multicopy genome called mitochondrial DNA (mtDNA). The occurrence or accumulation of mtDNA mutations underlies a s...
Nail Proximal Fold Stem Cells (NPFSCs) Participate In Nail Growth, Orchestrating Enhanced Digit Regeneration via BMP Signaling Activation [0.03%]
指甲近端褶皱干细胞通过BMP信号活化参与指甲生长并调控肢体再生
Anna Pulawska-Czub,Alicja Olczak-Cossu,Tomasz D Pieczonka et al.
Anna Pulawska-Czub et al.
Rodent and primate digit tips exhibit a remarkable regenerative capacity following amputation, driven by highly proliferative nail stem cells (NSCs) with active canonical Wnt signaling. Recently, a distinct, slow-cycling population of bi-fu...
Mesenchymal Stem Cell-Based Delivery Systems for the Treatment of Brain Tumors [0.03%]
基于间充质干细胞的脑肿瘤治疗输送系统
Mohammad Amin Bakhshan,Leila Chodari,Sayyed Jafar Hasani et al.
Mohammad Amin Bakhshan et al.
Brain tumors rank among the most lethal cancer types, accounting for high mortality rates in both pediatric and adult populations. They present formidable therapeutic obstacles owing to their intrinsically aggressive biology, the complexity...
Application of hiPSCs for tissue modeling and therapy: are we on track? [0.03%]
hiPSCs组织模型和治疗中的应用：我们是否步入正轨？
Mathew Nickel Maunu,Ingrid Meulenbelt,Yolande F M Ramos
Mathew Nickel Maunu
Stem cells are key for development of disease modeling and therapies. While promising, however, current application of cutting-edge hiPSC technologies is, among others, confounded by cellular heterogeneity leading to concerns about their su...
Huntington's Disease Human Lateral Ganglionic Eminence Precursors Differentiate into Functionally Mature Medium Spiny Neurons Exhibiting Pathology [0.03%]
亨廷顿病人类纹状体发出区前体细胞向中棘神经元分化并表现出病理学特征
Amy McCaughey-Chapman,Bronwen Connor
Amy McCaughey-Chapman
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease characterised by the loss of GABAergic medium spiny neurons (MSNs). Cellular models of HD are mainly derived from human embryonic stem cells or induced pluripotent...
Transplantation of human stem cell-derived cone photoreceptors partially restores vision in aged rd1 mice with advanced retinal degeneration [0.03%]
人干细胞衍生的视锥光感受器移植部分恢复了老化rd1小鼠晚期视网膜变性的眼视力
Christopher A Procyk,Anna Melati,Menahil Tariq et al.
Christopher A Procyk et al.
Targeted photoreceptor replacement therapy is a promising, potentially disease-agnostic approach for reversing sight-loss associated with advanced retinal degenerations, including age-related macular degeneration. We have previously shown t...