Thomas W C Knight,Ngefor Asangwe,Sadia Mohsin et al.
Thomas W C Knight et al.
The adult heart consists of a fixed number of cardiomyocytes (CMs) determined at birth. CMs once lost due to injury in the adult heart are never replaced, initiating a viscous cycle of adverse events leading to heart failure. Therapeutic in...
Bailey R Klein,Angella Blake,Ritisha Rashmil et al.
Bailey R Klein et al.
Hematopoietic stem cell (HSC) transplantation is a lifesaving therapy for hematologic diseases, but its broader application remains constrained by challenges in sourcing, manipulating, and reliably expanding functional HSCs. In this review,...
Unveiling the Gut-Pancreas Axis: Microbial Influence on Stemness and Tumor Microenvironment of PDAC [0.03%]
揭开肠-胰腺轴的面纱：微生物对胰腺导管腺癌干细胞特性及肿瘤微环境的影响
Kirtana Arikath,Surinder K Batra,Moorthy P Ponnusamy
Kirtana Arikath
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and malignant cancer of the pancreas characterized by various genetic mutations and metabolic dysregulations. Stem cells play a critical role in the initiation, progression, and resis...
Comment on "Critical role of the potential O-linked glycosylation sites of CXCR4 in cell migration and bone marrow homing of hematopoietic stem progenitor cells" [0.03%]
CXCR4潜在O-连接糖基化位点在细胞迁移及造血干细胞向骨髓归巢中所起关键作用的讨论
Shan Tao,Dongxue Zhuang,Chengqiang Jin
Shan Tao
This study by Pan et al. reveals the critical role of O-linked glycosylation at Ser-5 and Ser-9 of mouse CXCR4 in HSPC migration and BM homing. Using CRISPR/Cas9-mediated mutagenesis, in vitro assays, and in vivo models, they show these sit...
Exosomes derived from ADSC suppress endothelial cells ferroptosis and alleviate sepsis acute liver injury via regulation of Keap1/Nrf2/GPX4 axis: an experimental study [0.03%]
外源性ADSC衍生的外泌体通过调节Keap1/Nrf2/GPX4轴抑制内皮细胞铁死亡并缓解脓毒症急性肝损伤：一项实验研究
Xianqi Wang,Dan Wu,Xiaoyang Liu et al.
Xianqi Wang et al.
Background: Adipose-derived stem cells exosome (ADSC-exo) has been reported to be effective in alleviating organ dysfunction in sepsis, including acute liver injury (ALI). Whether ADSC-exo protects the liver via suppressi...
Critical insights into the role of miR-290 and miR-302 clusters in iPSC reprogramming [0.03%]
探讨miR-290簇和miR-302簇在诱导多能干细胞重编中的作用机制
Shan Tao,Xianghui Zhang,Chengqiang Jin
Shan Tao
The study by Ye et al., published in Stem Cells, represents a significant advancement in the field of cellular reprogramming and pluripotency. The authors meticulously investigate the essential roles of the miR-290 and miR-302 microRNA clus...
Erythropoietin-dependent Acquisition of CD71hiCD105hi Phenotype within CD235a- Early Erythroid Progenitors [0.03%]
人早期红系祖细胞中正向选择的红系终末分化命运抉择机制研究
Natascha Schippel,Mrinalini Kala,Shalini Sharma
Natascha Schippel
The development of committed erythroid progenitors and their continued maturation into erythrocytes requires the cytokine erythropoietin (Epo). Here, we describe the immunophenotypic identification of a CD34- colony-forming unit-erythroid (...
PNO1 served as a potential biomarker to promote the stemness and progression of breast cancer via the NF-κB signaling pathway [0.03%]
PNO1通过NF-κB信号通路促进乳腺癌干细胞特性及发展的潜能标志物研究
Xiaorui Wang,Ping Yue,Dongming Liu et al.
Xiaorui Wang et al.
Background: Breast cancer is a highly heterogeneous disease with diverse phenotypes. At present, increasing evidence supports the role of ribosomal biogenesis in human diseases and tumorigenesis. PNO1, as a ribosome assem...
The impact of donor and recipient age on post-transplantation clonality in murine haematopoiesis [0.03%]
供体和受体年龄对小鼠造血移植后克隆性的影响
Lars Thielecke,Kalpana Nattamai,Aishlin Hassan et al.
Lars Thielecke et al.
The sustained production of blood and immune cells is driven by a pool of hematopoietic stem cells (HSCs) and their offspring. Due to the intrinsic heterogeneity of HSCs, the composition of emergent clones changes over time, leading to a re...