Donor sex modulates hiPSC-derived cardiomyocyte metabolic and functional response to fatty acids [0.03%]
供体性别调节hiPSC衍生心肌细胞对脂肪酸的代谢和功能反应
Anna K McClain,Cody Callahan,Saivee S Shelke et al.
Anna K McClain et al.
Background: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable cardiovascular disease modeling and regenerative research but exhibit substantial heterogeneity and incomplete metabolic maturation...
Loss of ABCA4 from photoreceptor discs is associated with glial transcriptomic changes in retinal organoids [0.03%]
ABCA4蛋白从视杆细胞盘状体的丢失与视网膜类器官中胶质转录组的变化相关
Rossella Valenzano,Andrew McDonald,Carmen Gallego et al.
Rossella Valenzano et al.
Background: Loss-of-function mutations in the ABCA4 gene cause Stargardt disease (STGD1), the most common inherited macular dystrophy leading to progressive central vision loss. ...
Function-First Organoid Engineering for Regenerative Medicine: Current Challenges and Future Perspectives [0.03%]
功能优先的类器官工程在再生医学中的当前挑战与未来展望
Yusuke Nishimura
Yusuke Nishimura
Organoid technology has emerged as a powerful platform for modeling human development, disease, and drug responses. Advances in stem cell biology and bioengineering have enabled the generation of increasingly sophisticated organoid systems ...
Mesenchymal Stem Cells and Empagliflozin: a potential therapeutic approach for autophagy and Klotho modulation in Diabetic Kidney Disease [0.03%]
间充质干细胞与恩格列净：在糖尿病肾脏疾病中调节自噬和类固醇的潜在治疗手段
Marcella L Franco,Stephany Beyerstedt,Bruno S Barbosa et al.
Marcella L Franco et al.
Diabetic kidney disease (DKD), the leading cause of end-stage renal disease, involves injury across multiple renal compartments. Autophagy dysregulation is a key pathogenic mechanism and may reduce Klotho, a renoprotective protein diminishe...
Vacuolar protein sorting 4B is a novel regulator of osteoblast and adipocyte differentiation by activating autophagy signaling [0.03%]
溶酶体蛋白分选受体4B通过激活自噬信号促进成骨细胞和脂肪细胞分化
Jinyu Ma,Xingli Hu,Xinfeng Liu et al.
Jinyu Ma et al.
Vacuolar protein sorting 4B (VPS4B) is part of the endosomal sorting complex required for the transport (ESCRT) machinery and is essential for autophagosome completion. Vps4b mutation might reduce the ability of dental follicle cells to dif...
Engineering Neural Organoids: Technological Advances and Translational Frontiers [0.03%]
工程化类器官：技术前沿与转化机遇
Sungmin Kim,Hye-Ju Jo,Sung-Hwan Moon
Sungmin Kim
Neural organoids have transformed experimental neuroscience by enabling human-specific models of brain development, function, and disease. Emerging at the intersection of stem cell biology and tissue engineering, these self-organizing syste...
MSC-derived small extracellular vesicles promote dental pulp repair by alleviating inflammation in pulpitis via AKT and p38 MAPK pathways [0.03%]
牙髓炎中MSC来源的小细胞外囊泡通过AKT和p38MAPK通路缓解炎症促进牙髓修复
Jiajun Shi,Yuanyuan Jiang,Shipin Zhang et al.
Jiajun Shi et al.
Background: Pulpitis compromises dental pulp defense and repair, and current therapies inadequately resolve inflammation. Mesenchymal stem/stromal cell (MSC)-derived small extracellular vesicles (sEVs) exhibit potent anti...
Human iPSC-Derived 3D Cardiac Models for Cardiomyopathies: Organoids, Spheroids, and Engineered Heart Tissues as Translational Platforms [0.03%]
人多能干细胞来源的三维心脏模型在心肌病中的应用：类器官、球体和工程化心肌组织作为转化平台
Prabin Upadhyaya
Prabin Upadhyaya
Cardiomyopathies represent a substantial global health burden, yet progress in developing effective therapies was long constrained by the absence of physiologically relevant human models to understand molecular mechanisms and evaluating int...