Nicotinamide salvage is required for proliferation and sustaining self-renewal in undifferentiated embryonic stem cells
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Stem cells use oxidized nicotinamide adenine dinucleotide (NAD+) in distinct subcellular compartments to support self-renewal and to regulate chromatin. There is limited information, however, about the biosynthetic pathways that replenish intracellular NAD+, w... ...
