Prostaglandin E2 receptor EP2 is indispensable for maintenance of skeletal muscle stem cells [0.03%]
前列腺素E2受体EP2在维持肌肉干细胞方面的不可或缺作用
Yusuke Maruyama,Ken&#x;ichiro Nogami,Norio Motohashi et al.
Yusuke Maruyama et al.
Muscle satellite cells are adult muscle stem cells indispensable for growth and regeneration of postnatal skeletal muscle. Notch plays a central role in maintenance of muscle satellite cells, but how Notch maintains the muscle stem cell poo...
FAK inhibition following acute olfactory epithelial inflammation promotes neurogenesis and functional recovery through stem cell CNTF [0.03%]
急性嗅上皮炎症后FAK抑制通过干细胞CTNF促进神经发生和功能恢复
Derek Cox,Brian Wang,Jaeden Pyburn et al.
Derek Cox et al.
The sense of smell is maintained by regenerating olfactory sensory neurons (OSNs) from basal stem cells in the olfactory epithelium (OE). Acute inflammation destroys OSNs, causing hyposmia and anosmia, but activates basal cells. Manipulatio...
"Quiescence" in the resting zone of the growth plate: a systematic review [0.03%]
生长板静止区的“静止”状态：系统性综述
Mahtab Avijgan,Amal Nazaraliyev,Klas Blomgren et al.
Mahtab Avijgan et al.
Postnatal skeletal growth in childhood and adolescence depends on cartilage organs called (epiphyseal) growth plates. Studies in the last decade have identified populations of skeletal stem cells within mouse growth plates' resting zones. W...
Disease Modeling of Myocilin Mutation Dependent Normal Tension Glaucoma: Human Retinal Ganglion Cell Susceptibility to UPR and mTOR Signaling [0.03%]
肌动蛋白变异正常眼压型青光眼的疾病建模：人类视网膜神经节细胞对UPR和mTOR信号传导的敏感性
Subrata Kumar Shil,Murali Subramani,Matthew J Van Hook et al.
Subrata Kumar Shil et al.
Glaucoma represents a group of diseases where the unifying theme is the progressive degeneration of retinal ganglion cells (RGC), causing irreversible vision loss. Mutations in the myocilin (MYOC) gene represent one of the most common genet...
Extracellular vesicle microRNAs from human bone marrow MSCs suppress fibrogenesis of hepatic stellate cells by downregulation of RhoA signaling [0.03%]
人骨髓间充质干细胞来源的细胞外囊泡通过下调RhoA信号抑制肝星状细胞纤维化
Daiki Kawamoto,Toshihiko Matsumoto,Tsuyoshi Fujioka et al.
Daiki Kawamoto et al.
We have developed a liver regeneration therapy for decompensated liver cirrhosis (DLC) using autologous bone marrow mesenchymal stem cells (MSCs), and it is currently under trial (jRCT2063200014). However, the mechanism underlying the anti-...
Highly efficient induction of Sox9+ scl-progenitors from embryonic stem cells for skeletal modeling [0.03%]
高效诱导胚胎干细胞为骨骼建模的Sox9+scl-祖细胞
Yanhui Deng,Jingfei Xiong,Hanyi Chen et al.
Yanhui Deng et al.
Sclerotomal progenitors derived from pluripotent stem cells hold promises for modeling skeletal development and recapitulating the perinatal marrow niche that may provide insights into hematopoietic niche formation and immune regulation. Cu...
Mesenchymal stem cells derived EXO-miR3671 delivery promoted angiogenesis and accelerated wound healing of diabetes [0.03%]
外源性miR3671通过靶向KLF4促进糖尿病创面血管新生及伤口愈合
Jiannan Li,Sibing Chen,Huannan Wang et al.
Jiannan Li et al.
Objective: To explore the effect of exosomes-encapsulated miR3671 (EXO-miR3671) from mesenchymal stem cells (MSC) on diabetic wound healing and its mechanism. ...
ETV2-ECSCR-mTOR pathways regulate reprogramming to the endothelial lineage [0.03%]
ETV2-ECSCR-mTOR信号通路调控血管内皮细胞重编程路径
Young Geun Choi,Satyabrata Das,Thijs A Larson et al.
Young Geun Choi et al.
ETV2 is a pioneer factor that regulates cell fate decisions and direct reprogramming of the endothelial lineage. While ETV2 drives the cell fate conversion through epigenetic remodeling, its downstream targets also contribute to ETV2-mediat...
Hannah Willems,Reinhard Bauer,Jörg P Müller
Hannah Willems
Sirt7 is a member of the sirtuin family of proteins, which are NAD+-dependent deacetylases and ADP-ribosyltransferases. It is involved in a wide range of cellular processes. To study the specific role of Sirt7 in haematopoiesis during aging...
iPSC-derived modeling of HLA-lacking hematopoiesis reveals clonal diversity in eltrombopag response in acquired aplastic anemia [0.03%]
基于iPSC的无HLA造血模拟揭示了艾曲波帕在获得性再生障碍性贫血中的克隆多样性反应
Honoka Takahashi,Luna Seoka,Rio Takahashi et al.
Honoka Takahashi et al.
Acquired aplastic anemia (AA) is an immune-mediated bone marrow failure in which cytotoxic T lymphocytes (CTLs) target hematopoietic stem cells (HSCs). Approximately 30% of AA patients develop immune escape clones lacking specific HLA class...