From Bench to Bedside: Stem and Progenitor Cell-Derived Extracellular Vesicles in Cardiac Therapy [0.03%]
从实验室到临床：心肌细胞和前体细胞源外泌体在心脏疾病治疗中的应用
Carolina Balbi,Giulia A Vassalli-Sandal,Giuseppe Vassalli
Carolina Balbi
Initially regarded as insignificant cellular waste, extracellular vesicles (EVs) are now recognized as key mediators of intercellular communication, capable of transferring bioactive molecules-such as proteins, nucleic acids, and small comp...
Exosomes secreted by ADMSCs preserve cartilage integrity in knee osteoarthritis via AMPK-mediated mitochondrial dynamics and apoptosis [0.03%]
腺源性间充质干细胞分泌的外泌体通过AMPK介导的线粒体动力学和凋亡作用保护膝关节骨关节炎软骨完整性
Jinliang He,Yang Liu,Lu Zhang et al.
Jinliang He et al.
Adipose-derived mesenchymal stem cell (ADMSC) exosomes have emerged as promising therapeutic agents for degenerative joint diseases, yet their molecular actions in knee osteoarthritis (KOA) remain inadequately defined. In this study, exosom...
Derivation of functional early gestation decidual natural killer cell subtypes from induced pluripotent stem cells [0.03%]
从诱导多能干细胞中分化出功能性的早期着床阶段蜕膜自然杀伤细胞亚型
Virginia Chu Cheung,Jennifer Jaimez,Carly DaCosta et al.
Virginia Chu Cheung et al.
Abnormal decidual natural killer cell (dNK) function is linked to pregnancy complications occurring in both early and late gestation, including recurrent pregnancy loss, preeclampsia, and preterm birth. Exploration of dNK heterogeneity as i...
Stem cells enhance mitochondrial function in experimental Huntington's disease [0.03%]
干细胞可改善亨廷顿舞蹈病小鼠模型的线粒体功能
Francesco D&#x;Egidio,Napasiri Putthanbut,Michaela Starahs et al.
Francesco D&#x;Egidio et al.
Huntington's Disease (HD) is a neurodegenerative disorder caused by CAG triplet expansion in the HTT gene, producing a mutant Huntingtin protein that impairs mitochondrial dynamics by reducing fusion and increasing fission. Mesenchymal stem...
Synergizing Stem Cells with Biomaterials for Therapeutic Angiogenesis in Ischemic Diseases [0.03%]
干细胞与生物材料协同促进缺血性疾病治疗性新生血管化的作用
Taiyan Ji,Jiajia Shi,Jing Yang
Taiyan Ji
Therapeutic angiogenesis (TA) is a promising strategy for treating ischemic diseases, mainly by targeting the angiogenesis pathways and cells, particularly VEGF and endothelial progenitor cells. Although stem cell therapy has been extensive...
Cell Barcoding Reveals Lineage-dependent Outcomes in hiPSC Cardiac Differentiation [0.03%]
细胞条形码揭示hiPSC心脏分化中的谱系依赖性结果
Sogu Sohn,Daylin Morgan,Cody Callahan et al.
Sogu Sohn et al.
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have potential applications in treating cardiovascular disease but are currently limited in their clinical translation. This can be attributed in large part to the compl...
Dual Roles of MAPK-Mediated C/EBPβ Phosphorylation in Promoting Maturation and Suppressing EMT During Hepatocyte Differentiation from hESCs [0.03%]
MAPK介导的C/EBPβ磷酸化在促进人胚胎干细胞分化为肝细胞成熟和抑制上皮间质转化中的双重作用
Shoupei Liu,Xiangting Cao,Haibin Wu et al.
Shoupei Liu et al.
Human embryonic stem cell (hESC)-derived hepatocytes (hEHs) display functional deficits, particularly impaired albumin secretion and ammonia metabolism, compared to primary human hepatocytes (PHHs). Here, we investigated the regulatory role...
Stem Cell Therapies to Modulate Harmful Immune Responses in Kidney Disease: Progress Toward Clinical Validation [0.03%]
干细胞疗法在肾脏疾病中调节有害免疫反应的临床验证进展
Qifeng Ou,Fuxuan Li,Shengkun Wang et al.
Qifeng Ou et al.
Stem cell therapies hold promise for halting or reversing kidney disease and improving kidney transplant (KTx) outcomes. One route to large-scale clinical application of stem cell therapies for kidney disease is through their capacity to mo...
A mouse growth plate injury model identified contributions of pdgfra and pdgfrb cellular descendants to bony bar formation [0.03%]
Pdgfra和Pdgfrb细胞后裔在骨条形成中的作用——建立了一个鼠生长板损伤模型
Zhao Li,Myles Zhou,Xin Xing et al.
Zhao Li et al.
Growth plate injuries in pediatric patients can lead to serious musculoskeletal complications, such as bony bar formation and potential growth arrest. Current clinical treatments have significant limitations, necessitating improved research...
LARP7 Enhances the Potential of Dental Pulp Stem Cells to Promote Peripheral Nerve Repair [0.03%]
LARP7增强牙髓干细胞促进周围神经再生的潜能
Zihan Yang,Guanlin Qu,Xiping Wang et al.
Zihan Yang et al.
Background: Peripheral nerve injuries (PNIs) present a persistent clinical challenge because of the intrinsically limited regenerative capacity of peripheral nerves. While dental pulp stem cells (DPSCs) exhibit significan...