Comment on "Critical role of the potential O-linked glycosylation sites of CXCR4 in cell migration and bone marrow homing of hematopoietic stem progenitor cells"
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This study by Pan et al. reveals the critical role of O-linked glycosylation at Ser-5 and Ser-9 of mouse CXCR4 in HSPC migration and BM homing. Using CRISPR/Cas9-mediated mutagenesis, in vitro assays, and in vivo models, they show these sites are essential for... ...
