Liver Transplantation: A Test of Cellular Physiology, Preservation, and Injury [0.03%]
肝脏移植：细胞生理学、保存和损伤的检验
B Martins,J Mossemann,F Aguilar et al.
B Martins et al.
Liver transplantation has evolved into a mature clinical field, but scarcity of usable organs poses a unique challenge. Expanding the donor pool requires novel approaches for protecting hepatic physiology and cellular homeostasis. Here we d...
The Spectrum of Renal "TFEopathies": Flipping the mTOR Switch in Renal Tumorigenesis [0.03%]
肾TFE病的谱系：mTOR在肾脏肿瘤发生中的作用开关
Nicola Alesi,Kaushal Asrani,Tamara L Lotan et al.
Nicola Alesi et al.
The mammalian target of Rapamycin complex 1 (mTORC1) is a serine/threonine kinase that couples nutrient and growth factor signaling to the cellular control of metabolism and plays a fundamental role in aberrant proliferation in cancer. mTOR...
ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis [0.03%]
血管稳态的ECM微环境：动脉粥样硬化的新靶点
Lu Zhang,Qianqian Feng,Wei Kong
Lu Zhang
Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment...
Uterus Transplantation: The Translational Evolution of a Clinical Breakthrough [0.03%]
子宫移植：从临床突破到转化发展
Mats Brännström,Eli Y Adashi,Joseph Wu et al.
Mats Brännström et al.
Women suffering from absolute uterine factor infertility (AUFI), due to either lack of a uterus or one unable to sustain neonatal viability, presented as one of the last frontiers in conquering infertility. Following systematic animal resea...
Extrarenal benefits of SGLT2 inhibitors in the treatment of cardiomyopathy [0.03%]
SGLT2抑制剂在治疗心肌病中的肾外益处
Veera Ganesh Yerra,Kim A Connelly
Veera Ganesh Yerra
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have emerged as pivotal medications for heart failure, demonstrating remarkable cardiovascular benefits extending beyond their glucose-lowering effects. The unexpected cardiovascular advanta...
Physiology in Perspective [0.03%]
生理学教程
Nikki Forrester
Nikki Forrester
Cynthia J Downs,Marissa E Sobolewski
Cynthia J Downs
Most studies in comparative immunology involve investigations into the detailed mechanisms of the immune system of a non-model organism. Although this approach has been insightful, it has promoted a deep understanding of only a handful of s...
Wang-Soo Lee,E Dale Abel,Jaetaek Kim
Wang-Soo Lee
Insulin-like growth factor-1 (IGF-1) signaling has multiple physiological roles in cellular growth, metabolism, and aging. Myocardial hypertrophy, cell death, senescence, fibrosis, and electrical remodeling are hallmarks of various heart di...
Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease [0.03%]
健康与疾病状态下线粒体钙调控心脏代谢功能
Enrique Balderas,Sandra H J Lee,Neeraj K Rai et al.
Enrique Balderas et al.
Oxidative phosphorylation is regulated by mitochondrial calcium (Ca2+) in health and disease. In physiological states, Ca2+ enters via the mitochondrial Ca2+ uniporter and rapidly enhances NADH and ATP production. However, maintaining Ca2+ ...
Nrf2-Keap1 in Cardiovascular Disease: Which Is the Cart and Which the Horse? [0.03%]
心血管疾病中的Nrf2-Keap1：哪个是马拉车，哪个是车带马？
Neha Dhyani,Changhai Tian,Lie Gao et al.
Neha Dhyani et al.
High levels of oxidant stress in the form of reactive oxidant species are prevalent in the circulation and tissues in various types of cardiovascular disease including heart failure, hypertension, peripheral arterial disease, and stroke. He...