The Spectrum of Renal "TFEopathies": Flipping the mTOR Switch in Renal Tumorigenesis
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The mammalian target of Rapamycin complex 1 (mTORC1) is a serine/threonine kinase that couples nutrient and growth factor signaling to the cellular control of metabolism and plays a fundamental role in aberrant proliferation in cancer. mTORC1 has previously be... ...