Re-evaluating the site-directed nuclease classification as a regulatory trigger for genome-edited plant products [0.03%]
基于基因组编辑的植物产品重新评估位点特异性核酸酶分类的调控触发机制
Osman Mewett,John McMurdy,Lieselot Bertho et al.
Osman Mewett et al.
Quantification and transcriptome profiling reveal abundant, dynamic and translatable dephospho-CoA-capped RNAs [0.03%]
定量和转录组分析揭示了大量、动态且可翻译的去磷酸化CoA帽RNA
Hao Hu,Qiyue Zhang,Xuan Ma et al.
Hao Hu et al.
Cellular metabolites have emerged as noncanonical RNA caps. Despite its early discovery as an RNA cap, the dephospho-CoA (dpCoA) cap remains largely uncharacterized because of a lack of detection technologies. Here we use biochemical and st...
Erik Alexandersson,Thies Marten Heick,Anna Chailyan et al.
Erik Alexandersson et al.
Stanley T Crooke,Andrew W Lo
Stanley T Crooke
Considerations for the future of in vitro gametogenesis in fertility care [0.03%]
论体外生殖细胞发生技术在辅助生育中的前景及思考
Hannah L Landecker,Amander T Clark
Hannah L Landecker
Highly mutagenic continuous evolution in E. coli using a Φ29-based orthogonal replication system [0.03%]
基于Φ29的正交复制系统在大肠杆菌中实现高度诱变的连续进化
Fabian B H Rehm,Kim C Liu,Rongzhen Tian et al.
Fabian B H Rehm et al.
Organisms that permit hypermutation of target genes without off-target mutagenesis of the host genome enable the accelerated, continuous evolution of genes for new or enhanced functions. We develop and optimize an orthogonal DNA replication...
Agentic AI and the rise of in silico team science in biomedical research [0.03%]
代理人工智能与生物医学研究中基于计算机的团队科学的崛起
Binglan Li,Anil Kumar Saini,Jose Guadalupe Hernandez et al.
Binglan Li et al.
Agentic artificial intelligence (AI) systems are emerging as teams of intelligent computational experts capable of rivaling human performance in labor-intensive tasks, including literature review, hypothesis formulation, data analysis and m...
Iris Marchal
Iris Marchal
Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR [0.03%]
利用scHiCAR对复杂组织中转录组、表观基因组和三维基因组进行三模态单细胞分析
Xiaolin Wei,Yueyuan Xu,Dongchan Yang et al.
Xiaolin Wei et al.
The three-dimensional (3D) organization of cis-regulatory elements (CREs) is critical in transcription control. However, capturing transcriptome, epigenome and 3D genome from the same single cells remains challenging. Here we present scHiCA...