Amelia Palermo
Amelia Palermo
Author Correction: Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy [0.03%]
作者更正：工程大肠杆菌持续产生一氧化氮可重塑肿瘤微环境并增强免疫疗法
Shuyu Xu,Tianjiao Zhang,Yang Song et al.
Shuyu Xu et al.
Published Erratum
Nature biotechnology. 2026 Jul 6. DOI:10.1038/s41587-026-03247-5 2026
Author Correction: Improved RNA base editing with guide RNAs mimicking highly edited endogenous ADAR substrates [0.03%]
作者更正：通过模仿高度改编的内源性ADAR底物的向导RNA改进RNA碱基编辑
Yuanfan Sun,Yong Cao,Yulong Song et al.
Yuanfan Sun et al.
Published Erratum
Nature biotechnology. 2026 Jul 3. DOI:10.1038/s41587-026-03246-6 2026
A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells [0.03%]
人类诱导多能干细胞基因组范围的CRISPRi扰动图集
Sami Nourreddine,Yesh Doctor,Amir Dailamy et al.
Sami Nourreddine et al.
Comprehensively mapping the relationship between genotype and phenotype offers essential insights into how a cell's state arises from its genetic components. Toward this goal, we generated an expressed genome-scale CRISPRi perturbation cell...
Prime editing for precise genome engineering and modulation of fungal metabolism [0.03%]
精准基因编辑及其在调控真菌代谢中的应用
Chunxiao Sun,Qiuyue Nie,Naomi Straub et al.
Chunxiao Sun et al.
Prime editing has not been established in filamentous fungi, which are major ecological contributors and industrial hosts with vast biosynthetic capacity. Here we develop fPE7max, a prime editing platform optimized for fungi, which supports...
Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells [0.03%]
用于人类细胞中大DNA序列一步、精准整合的丝氨酸重组酶
Friedrich Fauser,Sebastian Arangundy-Franklin,Jessica E Davis et al.
Friedrich Fauser et al.
Serine integrases can precisely integrate large DNA constructs into desired chromosomal sites but only if their natural target site is first installed into the recipient genome. Here, to retarget serine integrases to a desired genomic site,...
Frank Buchholz
Frank Buchholz
Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles [0.03%]
实验引导的AlphaFold3解析出测量一致的蛋白质集合体
Advaith Maddipatla,Nadav Sellam Bojan,Meital Bojan et al.
Advaith Maddipatla et al.
AlphaFold3 predicts highly accurate protein structures from sequence but tends to collapse to a single dominant conformation, even when the underlying structure is inherently heterogeneous. Moreover, its predictions are oblivious to experim...