Yinuo Jiang,Bing He,Zihan Wu et al.
Yinuo Jiang et al.
Homology search plays a fundamental role in computational biology, enabling the identification of evolutionary relationships and functional similarities among biological sequences. However, current homology search methods, including BLAST, ...
Zijing Yu,Bei Zheng,Yajing Zhan et al.
Zijing Yu et al.
Dual-objective 4Pi single-molecule localization microscopy (4Pi-SMLM) offers isotropic nanoscale resolution; however, its broader adoption is limited by instrumental complexity and stringent alignment requirements. Here we introduce mirror-...
Alina Isakova,Daniel Dan Liu,Ivana Cvijović et al.
Alina Isakova et al.
Current single-cell RNA atlases largely capture polyadenylated transcripts while missing critical regulatory layers from noncoding RNA. To address this, we develop a generalizable framework that adapts total RNA profiling for use in standar...
Evan D Groover,David Ding,Flora Z Wang et al.
Evan D Groover et al.
Precise modulation of gene expression through cis-regulatory editing holds promise for nontransgenic crop improvement. However, the sequence-to-function relationships that govern plant promoter activity remain poorly understood. Here we dev...
Mikaela Koutrouli,Francesca Finotello,Erwin M Schoof et al.
Mikaela Koutrouli et al.
Jim Shaw,Maximillian G Marin,Heng Li
Jim Shaw
Long-read metagenome assembly promises complete genomic recovery from microbiomes. However, the complexity of metagenomes poses challenges. Here we present myloasm, a metagenome assembler for modern long reads such as PacBio HiFi and Oxford...
DNA-drug conjugates enable logic-gated drug delivery amplified by hybridization chain reactions [0.03%]
Si-Kai Chen,Miguel López-Tena,Francesco Russo et al.
Si-Kai Chen et al.
Antibody-drug conjugates enable highly specific delivery of potent cytotoxics to biomarker-expressing cells. In parallel, advances in DNA circuitry and DNA-protein conjugates have allowed programmable integration of molecular inputs and sig...
Vishwanatha M Rao,Serena Zhang,Brian S Plosky et al.
Vishwanatha M Rao et al.
Generalist biological artificial intelligence (GBAI) represents a transformative approach to modeling the 'language of life'-the flow of information from DNA to cellular function. This Review synthesizes rapid advances in biological AI to i...