Bonsai reconstructs tree representations for distortion-free visualization and exploration of high-dimensional data [0.03%]
bonsai：高维数据免失真可视化与探索的树形表示重建方法
Daan H de Groot,Sarah X Morillo Leonardo,Mikhail Pachkov et al.
Daan H de Groot et al.
Single-cell omics methods provide sparse, noisy measurements of high-dimensional cell states, whose underlying distributions remain poorly understood, raising an urgent need for exploratory analysis and visualization methods. However, curre...
Author Correction: Derivation of embryonic stem cells across avian species [0.03%]
作者更正：跨鸟类品种的胚胎干细胞衍生化
Xi Chen,Zheng Guo,Xinyi Tong et al.
Xi Chen et al.
Published Erratum
Nature biotechnology. 2026 Aug 19. DOI:10.1038/s41587-026-03309-8 2026
Enhanced antitumor immunity of mRNA vaccines by bioorthogonal-like delayed activation of exogeneous STING [0.03%]
基于生物正交延迟激活外源STING增强mRNA疫苗的抗肿瘤免疫效果
Pengxia Qin,Qiushi Qin,Yanyun Hao et al.
Pengxia Qin et al.
The development of cGAS-STING (stimulator of interferon genes) agonists as mRNA vaccine adjuvants has been hampered by widespread STING expression and by the observation that codelivered STING agonists suppress antigen mRNA translation. Her...
A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability [0.03%]
基于亲和力和成药性的实验数据进行的计算抗体发现的前瞻性盲测研究基准分析
M Frank Erasmus,Daniel Bedinger,Elizabeth Hopkins et al.
M Frank Erasmus et al.
Experimentally validated prospective, blinded benchmarks are needed to separate durable advances from hype in computational antibody design. Here AIntibody, a challenge inspired by the Critical Assessment of Structure Prediction, tests 511 ...
High-throughput synthesis of DNA fragments by molecular self-assembly of overlapping oligonucleotides [0.03%]
通过寡核苷酸分子自组装的重叠PCR实现高通量DNA合成
Zhiguang Wu,Zhengyang Sun,Shuangying Jiang et al.
Zhiguang Wu et al.
The limitations of DNA synthesis technologies are a fundamental bottleneck in synthetic biology. Here we present a high-throughput gene synthesis method driven by hybridization, called Molecular Self-Assembly Induced Cloning. Molecular Self...
Lessons from drug revenue life cycles: distributions across modalities and therapeutic areas [0.03%]
药物收入生命周期的启示：不同给药途径及治疗领域的分布差异
Matthew Vogel,Zander Cowan,Amitabh Chandra
Matthew Vogel
Ken Garber
Ken Garber
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells [0.03%]
病毒样颗粒能够在人类原代髓系细胞中实现靶向基因工程和池CRISPR筛选
Hyuncheol Jung,Pascal Devant,Carter Ching et al.
Hyuncheol Jung et al.
Primary human myeloid cells hold promise for immunotherapies, yet efficient, scalable technologies for engineering and screening in these cells remain limited. Here we present a virus-like particle (VLP)-based toolkit that delivers diverse ...