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Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR

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The three-dimensional (3D) organization of cis-regulatory elements (CREs) is critical in transcription control. However, capturing transcriptome, epigenome and 3D genome from the same single cells remains challenging. Here we present scHiCAR (single-cell Hi-C ... ...