Structural mechanism of muscle nicotinic receptor desensitization and block by curare [0.03%]
箭毒通过结构机制阻断烟碱型乙酰胆碱受体引发肌肉脱敏作用
Md Mahfuzur Rahman,Tamara Basta,Jinfeng Teng et al.
Md Mahfuzur Rahman et al.
Binding of the neurotransmitter acetylcholine to its receptors on muscle fibers depolarizes the membrane and thereby triggers muscle contraction. We sought to understand at the level of three-dimensional structure how agonists and antagonis...
Re-wiring for starvation [0.03%]
重新连线以应对饥荒
Carolina N Perdigoto
Carolina N Perdigoto
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH [0.03%]
人糖蛋白GP-2及尿酸酶的诱饵模块结构及其与细菌粘附素FimH的相互作用
Alena Stsiapanava,Chenrui Xu,Shunsuke Nishio et al.
Alena Stsiapanava et al.
Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cr...
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex [0.03%]
联体会议 EM 揭示 SARS-CoV-2 解旋酶复制-转录复合物中 nsp13 解旋酶的构象状态
James Chen,Qi Wang,Brandon Malone et al.
James Chen et al.
The SARS-CoV-2 nonstructural proteins coordinate genome replication and gene expression. Structural analyses revealed the basis for coupling of the essential nsp13 helicase with the RNA-dependent RNA polymerase (RdRp) where the holo-RdRp an...
Pujuan Deng,Jun-Jie Gogo Liu
Pujuan Deng
Wen-Ting Lo,Yingyi Zhang,Oscar Vadas et al.
Wen-Ting Lo et al.
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) is an essential member of the structurally unresolved class II PI3K family with crucial functions in lipid signaling, endocytosis, angiogenesis, viral replication, platelet formation and a r...
The oxytocin signaling complex reveals a molecular switch for cation dependence [0.03%]
催产素信号复合物揭示了阳离子依赖的分子开关
Justin G Meyerowitz,Michael J Robertson,Ximena Barros-Álvarez et al.
Justin G Meyerowitz et al.
Oxytocin (OT) and vasopressin (AVP) are conserved peptide signaling hormones that are critical for diverse processes including osmotic homeostasis, reproduction, lactation and social interaction. OT acts through the oxytocin receptor (OTR),...
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes [0.03%]
SARS-CoV-2刺突蛋白开放三聚体构象的可逆转换使其暴露新颖表位
Shawn M Costello,Sophie R Shoemaker,Helen T Hobbs et al.
Shawn M Costello et al.
Current COVID-19 vaccines and many clinical diagnostics are based on the structure and function of the SARS-CoV-2 spike ectodomain. Using hydrogen-deuterium exchange monitored by mass spectrometry, we have uncovered that, in addition to the...
Michael J Robertson,Justin G Meyerowitz,Ouliana Panova et al.
Michael J Robertson et al.
Somatostatin is a signaling peptide that plays a pivotal role in physiologic processes relating to metabolism and growth through its actions at somatostatin receptors (SSTRs). Members of the SSTR subfamily, particularly SSTR2, are key drug ...
Henning Arlt,Xuewu Sui,Brayden Folger et al.
Henning Arlt et al.
Lipid droplets (LDs) form in the endoplasmic reticulum by phase separation of neutral lipids. This process is facilitated by the seipin protein complex, which consists of a ring of seipin monomers, with a yet unclear function. Here, we repo...