Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation [0.03%]
相分离驱动线粒体核区的自我组装以调节转录
Qi Long,Yanshuang Zhou,Hao Wu et al.
Qi Long et al.
Mitochondria, the only semiautonomous organelles in mammalian cells, possess a circular, double-stranded genome termed mitochondrial DNA (mtDNA). While nuclear genomic DNA compaction, chromatin compartmentalization and transcription are kno...
Publisher Correction: Molnupiravir: coding for catastrophe [0.03%]
《Publishing Correction：Molnupiravir：灾难的编码》
注意：这里的翻译是直译，实际上“coding for catastrophe”更贴近语境的翻译可能是“编程错误导致灾难”或者“设计缺陷引发灾难”。由于上下文信息不足，“Molnupiravir”是一种药物名称，在不改变原意的情况下没有进行翻译。更为准确和贴切的中文标题可能需要更多的背景信息来确定。
Brandon Malone,Elizabeth A Campbell
Brandon Malone
Published Erratum
Nature structural & molecular biology. 2021 Nov;28(11):955. DOI:10.1038/s41594-021-00683-6 2021
The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes [0.03%]
人类Xkr8-基根素复合物的三级结构可在质膜上交换磷脂化合物
Takaharu Sakuragi,Ryuta Kanai,Akihisa Tsutsumi et al.
Takaharu Sakuragi et al.
Xkr8-Basigin is a plasma membrane phospholipid scramblase activated by kinases or caspases. We combined cryo-EM and X-ray crystallography to investigate its structure at an overall resolution of 3.8 Å. Its membrane-spanning region carrying...
Higher-order phosphatase-substrate contacts terminate the integrated stress response [0.03%]
更高阶的磷酸酶-底物接触终止整合应激反应
Yahui Yan,Heather P Harding,David Ron
Yahui Yan
Many regulatory PPP1R subunits join few catalytic PP1c subunits to mediate phosphoserine and phosphothreonine dephosphorylation in metazoans. Regulatory subunits engage the surface of PP1c, locally affecting flexible access of the phosphope...
Venkatesh P Mysore,Zhi-Wei Zhou,Chiara Ambrogio et al.
Venkatesh P Mysore et al.
The protein K-Ras functions as a molecular switch in signaling pathways regulating cell growth. In the human mitogen-activated protein kinase (MAPK) pathway, which is implicated in many cancers, multiple K-Ras proteins are thought to assemb...
Daniel R Dempsey,Thibault Viennet,Reina Iwase et al.
Daniel R Dempsey et al.
Phosphatase and tensin homolog (PTEN) is a phosphatidylinositol-3,4,5-triphosphate (PIP3) phospholipid phosphatase that is commonly mutated or silenced in cancer. PTEN's catalytic activity, cellular membrane localization and stability are o...
John F Hancock,Alemayehu A Gorfe
John F Hancock
Beth Moorefield
Beth Moorefield
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency [0.03%]
PRC1通过调控转录起始和爆发频率来驱动Polycomb介导的基因抑制
Paula Dobrinić,Aleksander T Szczurek,Robert J Klose
Paula Dobrinić
The Polycomb repressive system plays a fundamental role in controlling gene expression during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) bind target genes and use histone modification-depen...
Florian Ullrich
Florian Ullrich