Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads [0.03%]
有助于FUS SYGQ LC-RGG相分离和与RNA聚合酶II七聚体共分隔的分子相互作用
Anastasia C Murthy,Wai Shing Tang,Nina Jovic et al.
Anastasia C Murthy et al.
The RNA-binding protein FUS (Fused in Sarcoma) mediates phase separation in biomolecular condensates and functions in transcription by clustering with RNA polymerase II. Specific contact residues and interaction modes formed by FUS and the ...
Irene Farabella,Marco Di Stefano,Paula Soler-Vila et al.
Irene Farabella et al.
An increasing number of long noncoding RNAs (lncRNAs) have been proposed to act as nuclear organization factors during interphase. Direct RNA-DNA interactions can be achieved by the formation of triplex helix structures where a single-stran...
Martin D Jansson,Sophia J Häfner,Kübra Altinel et al.
Martin D Jansson et al.
Ribosomes are complex ribozymes that interpret genetic information by translating messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been documented in several organisms and can arise from several different so...
Structural basis and mechanism of activation of two different families of G proteins by the same GPCR [0.03%]
同一GPCR活化两种不同家族的G蛋白的结构基础和机制
Kamela O Alegre,Navid Paknejad,Minfei Su et al.
Kamela O Alegre et al.
The β1-adrenergic receptor (β1-AR) can activate two families of G proteins. When coupled to Gs, β1-AR increases cardiac output, and coupling to Gi leads to decreased responsiveness in myocardial infarction. By comparative structural anal...
Alexander S Hauser,Albert J Kooistra,Christian Munk et al.
Alexander S Hauser et al.
Two-thirds of human hormones and one-third of clinical drugs activate ~350 G-protein-coupled receptors (GPCR) belonging to four classes: A, B1, C and F. Whereas a model of activation has been described for class A, very little is known abou...
Albert J Kooistra,Christian Munk,Alexander S Hauser et al.
Albert J Kooistra et al.
We present an online, interactive platform for comparative analysis of all available G-protein coupled receptor (GPCR) structures while correlating to functional data. The comprehensive platform encompasses structure similarity, secondary s...
A modulator-bound GPCR structure enables allosteric non-opioid analgesia [0.03%]
与调制器结合的GPCR结构能够实现非阿片类异源镇痛作用
David F Lee,Matan Geron,Grégory Scherrer
David F Lee
Networking counters stress [0.03%]
人际交往缓解压力
Florian Ullrich
Florian Ullrich
Beth Moorefield
Beth Moorefield
The case for post-predictional modifications in the AlphaFold Protein Structure Database [0.03%]
AlphaFold蛋白质结构数据库中后预测修改的案例说明
Haroldas Bagdonas,Carl A Fogarty,Elisa Fadda et al.
Haroldas Bagdonas et al.