PARP inhibition impedes the maturation of nascent DNA strands during DNA replication [0.03%]
DNA复制过程中，PARP抑制阻碍新生DNA链成熟
Alina Vaitsiankova,Kamila Burdova,Margarita Sobol et al.
Alina Vaitsiankova et al.
Poly(ADP-ribose) polymerase 1 (PARP1) is implicated in the detection and processing of unligated Okazaki fragments and other DNA replication intermediates, highlighting such structures as potential sources of genome breakage induced by PARP...
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation [0.03%]
去甲肾上腺素代谢物DOPEGAL对tau的修饰促使其病理和传播
Seong Su Kang,Lanxia Meng,Xingyu Zhang et al.
Seong Su Kang et al.
The noradrenergic locus ceruleus (LC) is the first site of detectable tau pathology in Alzheimer's disease (AD), but the mechanisms underlying the selective vulnerability of the LC in AD have not been completely identified. In the present s...
Juan C Castaneda,Marina Schrecker,Dirk Remus et al.
Juan C Castaneda et al.
Single-stranded or double-stranded DNA junctions with recessed 5' ends serve as loading sites for the checkpoint clamp, 9-1-1, which mediates activation of the apical checkpoint kinase, ATRMec1. However, the basis for 9-1-1's recruitment to...
DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp [0.03%]
DNA通过复制应激检查点钳9-1-1的方向与PCNA相反
Fengwei Zheng,Roxana E Georgescu,Nina Y Yao et al.
Fengwei Zheng et al.
The 9-1-1 DNA checkpoint clamp is loaded onto 5'-recessed DNA to activate the DNA damage checkpoint that arrests the cell cycle. The 9-1-1 clamp is a heterotrimeric ring that is loaded in Saccharomyces cerevisiae by Rad24-RFC (hRAD17-RFC), ...
Andrea Cerase,J Mauro Calabrese,Gian Gaetano Tartaglia
Andrea Cerase
Sara Osman
Sara Osman
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome [0.03%]
Xist通过空间放大SHARP/SPEN募集来平衡整个染色体的沉默并与X染色体特异性相结合
Joanna W Jachowicz,Mackenzie Strehle,Abhik K Banerjee et al.
Joanna W Jachowicz et al.
Although thousands of long non-coding RNAs (lncRNAs) are encoded in mammalian genomes, their mechanisms of action are poorly understood, in part because they are often expressed at lower levels than their proposed targets. One such lncRNA i...
Beth Moorefield
Beth Moorefield
Florian Ullrich
Florian Ullrich
Acetylation-dependent SAGA complex dimerization promotes nucleosome acetylation and gene transcription [0.03%]
乙酰化依赖的SAGA复合物二聚化促进核小体乙酰化和基因转录
Junhua Huang,Wenjing Dai,Duncheng Xiao et al.
Junhua Huang et al.
Cells reprogram their transcriptomes to adapt to external conditions. The SAGA (Spt-Ada-Gcn5 acetyltransferase) complex is a highly conserved transcriptional coactivator that plays essential roles in cell growth and development, in part by ...