Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation [0.03%]
V-ATPase可逆解离过程中V1复合物的协调构象变化
Thamiya Vasanthakumar,Kristine A Keon,Stephanie A Bueler et al.
Thamiya Vasanthakumar et al.
Vacuolar-type ATPases (V-ATPases) are rotary enzymes that acidify intracellular compartments in eukaryotic cells. These multi-subunit complexes consist of a cytoplasmic V1 region that hydrolyzes ATP and a membrane-embedded VO region that tr...
Snapshots of actin and tubulin folding inside the TRiC chaperonin [0.03%]
捕捉TRiC分子伴侣中肌动蛋白和微管蛋白的折叠过程中的瞬间状态
John J Kelly,Dale Tranter,Els Pardon et al.
John J Kelly et al.
The integrity of a cell's proteome depends on correct folding of polypeptides by chaperonins. The chaperonin TCP-1 ring complex (TRiC) acts as obligate folder for >10% of cytosolic proteins, including he cytoskeletal proteins actin and tubu...
Author Correction: SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity [0.03%]
作者更正：类似SETDB1的MET-2在缺乏其H3K9三甲基化相关催化活性的情况下可独立促进转录沉默和发育
Colin E Delaney,Stephen P Methot,Veronique Kalck et al.
Colin E Delaney et al.
Published Erratum
Nature structural & molecular biology. 2022 May;29(5):502. DOI:10.1038/s41594-022-00776-w 2022
Keda Zhou,Magdalena Gebala,Dustin Woods et al.
Keda Zhou et al.
The histone variant CENP-A is the epigenetic determinant for the centromere, where it is interspersed with canonical H3 to form a specialized chromatin structure that nucleates the kinetochore. How nucleosomes at the centromere arrange into...
Katrina V Good,Juan Ausió
Katrina V Good
A tweak and a peek: How Cas9 pries open double-stranded DNA to check its sequence [0.03%]
一探与二看：Cas9 如何撬开双链DNA以检查其序列
Selma Sinan,Rick Russell
Selma Sinan
Joshua C Cofsky,Katarzyna M Soczek,Gavin J Knott et al.
Joshua C Cofsky et al.
In bacterial defense and genome editing applications, the CRISPR-associated protein Cas9 searches millions of DNA base pairs to locate a 20-nucleotide, guide RNA-complementary target sequence that abuts a protospacer-adjacent motif (PAM). T...
David Jeruzalmi
David Jeruzalmi
Beth Moorefield
Beth Moorefield
Jie Li,Junhee Park,John P Mayer et al.
Jie Li et al.
Insulin receptor (IR) signaling controls multiple facets of animal physiology. Maximally four insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise functional roles of each binding event during IR activat...