Coupling of distant ATPase domains in the circadian clock protein KaiC [0.03%]
光周期钟蛋白KaiC远距离ATP酶结构域之间的偶联现象
Jeffrey A Swan,Colby R Sandate,Archana G Chavan et al.
Jeffrey A Swan et al.
The AAA+ family member KaiC is the central pacemaker for circadian rhythms in the cyanobacterium Synechococcus elongatus. Composed of two hexameric rings of adenosine triphosphatase (ATPase) domains with tightly coupled activities, KaiC und...
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism [0.03%]
P-Rex1致癌转移因子的结构揭示了双层自动抑制机制
Yong-Gang Chang,Christopher J Lupton,Charles Bayly-Jones et al.
Yong-Gang Chang et al.
P-Rex (PI(3,4,5)P3-dependent Rac exchanger) guanine nucleotide exchange factors potently activate Rho GTPases. P-Rex guanine nucleotide exchange factors are autoinhibited, synergistically activated by Gβγ and PI(3,4,5)P3 binding and dysre...
Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3 [0.03%]
Get3尾锚定靶向因子的催化循环的结构衍生通用机制
Michelle Y Fry,Vladimíra Najdrová,Ailiena O Maggiolo et al.
Michelle Y Fry et al.
Tail-anchored (TA) membrane proteins, accounting for roughly 2% of proteomes, are primarily targeted posttranslationally to the endoplasmic reticulum membrane by the guided entry of TA proteins (GET) pathway. For this complicated process, i...
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate [0.03%]
磷酸化和葡萄糖-6-磷酸的人糖原合酶调节的分子基础
Thomas J McCorvie,Paula M Loria,Meihua Tu et al.
Thomas J McCorvie et al.
Glycogen synthase (GYS1) is the central enzyme in muscle glycogen biosynthesis. GYS1 activity is inhibited by phosphorylation of its amino (N) and carboxyl (C) termini, which is relieved by allosteric activation of glucose-6-phosphate (Glc6...
Domenic N Narducci,Anders S Hansen
Domenic N Narducci
Structural maintenance of chromosomes (SMC) complexes such as condensin regulate chromosome organization by extruding loops. A new study uses single-molecule imaging of condensin on supercoiled DNA to understand how condensins navigate the ...
Ashley M Toye
Ashley M Toye
Inactive and active state structures template selective tools for the human 5-HT5A receptor [0.03%]
人类5-羟色胺5A受体的非活性和活性构象模板选择工具
Shicheng Zhang,He Chen,Chengwei Zhang et al.
Shicheng Zhang et al.
Serotonin receptors are important targets for established therapeutics and drug development as they are expressed throughout the human body and play key roles in cell signaling. There are 12 serotonergic G protein-coupled receptor members e...
Kinetic principles underlying pioneer function of GAGA transcription factor in live cells [0.03%]
GAGA转录因子在活细胞中作为拓殖因子的动力学原理
Xiaona Tang,Taibo Li,Sheng Liu et al.
Xiaona Tang et al.
How pioneer factors interface with chromatin to promote accessibility for transcription control is poorly understood in vivo. Here, we directly visualize chromatin association by the prototypical GAGA pioneer factor (GAF) in live Drosophila...
Francesca Vallese,Kookjoo Kim,Laura Y Yen et al.
Francesca Vallese et al.
The stability and shape of the erythrocyte membrane is provided by the ankyrin-1 complex, but how it tethers the spectrin-actin cytoskeleton to the lipid bilayer and the nature of its association with the band 3 anion exchanger and the Rhes...