The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1 [0.03%]
人类神经纤维蛋白二聚体的冷冻电镜结构揭示了1型神神经纤维瘤病分子基础
Christopher J Lupton,Charles Bayly-Jones,Laura D&#x;Andrea et al.
Christopher J Lupton et al.
Neurofibromin (NF1) mutations cause neurofibromatosis type 1 and drive numerous cancers, including breast and brain tumors. NF1 inhibits cellular proliferation through its guanosine triphosphatase-activating protein (GAP) activity against r...
Zhi-Xiong Zhou,Scott A Lujan,Adam B Burkholder et al.
Zhi-Xiong Zhou et al.
Accurate DNA replication of an undamaged template depends on polymerase selectivity for matched nucleotides, exonucleolytic proofreading of mismatches, and removal of remaining mismatches via DNA mismatch repair (MMR). DNA polymerases (Pols...
MacroH2A1.1 has evolved to let PARP1 do more by loosening its grip on PAR [0.03%]
MacroH2A1.1通过放松对PAR的控制让PARP1发挥更大作用进化而来
Gregory A Hamilton,Matthew J Gamble
Gregory A Hamilton
Author Correction: Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation [0.03%]
作者更正：相分离驱动线粒体核区自组装以调节转录
Qi Long,Yanshuang Zhou,Hao Wu et al.
Qi Long et al.
Published Erratum
Nature structural & molecular biology. 2021 Dec;28(12):1050. DOI:10.1038/s41594-021-00705-3 2021
Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly [0.03%]
VCP/p97在PP1复合物拆卸过程中针对底物环的插入事件
Johannes van den Boom,Anja F Kueck,Bojana Kravic et al.
Johannes van den Boom et al.
The AAA-ATPase VCP/p97/Cdc48 unfolds proteins by threading them through its central pore, but how substrates are recognized and inserted into the pore in diverse pathways has remained controversial. Here, we show that p97, with its adapter ...
Seychelle M Vos
Seychelle M Vos
Dominik A Herbst,Meagan N Esbin,Robert K Louder et al.
Dominik A Herbst et al.
The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, DNA damage repair and signaling. While structures of yeast SAGA (ySAGA) have been reported, there are noteworthy functional and compositional differen...
Scaffolding protein CcmM directs multiprotein phase separation in β-carboxysome biogenesis [0.03%]
支架蛋白CcmM指导β-羧酶体生物发生中的多蛋白液-液相分离
Kun Zang,Huping Wang,F Ulrich Hartl et al.
Kun Zang et al.
Carboxysomes in cyanobacteria enclose the enzymes Rubisco and carbonic anhydrase to optimize photosynthetic carbon fixation. Understanding carboxysome assembly has implications in agricultural biotechnology. Here we analyzed the role of the...