Carolina N Perdigoto
Carolina N Perdigoto
Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST [0.03%]
填补空白：端粒酶通过CST追赶G链以完成染色体末端DNA复制
Conner L Olson,Alexandra T Barbour,Deborah S Wuttke
Conner L Olson
Jesús R Requena
Jesús R Requena
Karl Frontzek,Marco Bardelli,Assunta Senatore et al.
Karl Frontzek et al.
Prion infections cause conformational changes of the cellular prion protein (PrPC) and lead to progressive neurological impairment. Here we show that toxic, prion-mimetic ligands induce an intramolecular R208-H140 hydrogen bond ('H-latch'),...
King L Hung,Paul S Mischel,Howard Y Chang
King L Hung
Oncogene amplification on extrachromosomal DNA (ecDNA) is prevalent in human cancer and is associated with poor outcomes. Clonal, megabase-sized circular ecDNAs in cancer are distinct from nonclonal, small sub-kilobase-sized DNAs that may a...
Conformational buffering underlies functional selection in intrinsically disordered protein regions [0.03%]
构象缓冲作用决定了内在无序蛋白质区域的功能选择性
Nicolás S González-Foutel,Juliana Glavina,Wade M Borcherds et al.
Nicolás S González-Foutel et al.
Many disordered proteins conserve essential functions in the face of extensive sequence variation, making it challenging to identify the mechanisms responsible for functional selection. Here we identify the molecular mechanism of functional...
The structure-specific endonuclease complex SLX4-XPF regulates Tus-Ter-induced homologous recombination [0.03%]
SLX4-XPF结构特异性核酸内切酶复合体可调节Tus-Ter诱导的同源重组
Rajula Elango,Arvind Panday,Francis P Lach et al.
Rajula Elango et al.
Vertebrate replication forks arrested at interstrand DNA cross-links (ICLs) engage the Fanconi anemia pathway to incise arrested forks, 'unhooking' the ICL and forming a double strand break (DSB) that is repaired by homologous recombination...
Shaun Rawson,Richard M Walsh Jr,Benjamin Velez et al.
Shaun Rawson et al.
Proteasome inhibitors are widely used as therapeutics and research tools, and typically target one of the three active sites, each present twice in the proteasome complex. An endogeneous proteasome inhibitor, PI31, was identified 30 years a...
Mechanism of client selection by the protein quality-control factor UBE2O [0.03%]
蛋白质量控制因子UBE2O选择客户蛋白的机制研究
Matthew C J Yip,Samantha F Sedor,Sichen Shao
Matthew C J Yip
The E2/E3 enzyme UBE2O ubiquitylates diverse clients to mediate important processes, including targeting unassembled 'orphan' proteins for quality control and clearing ribosomes during erythropoiesis. How quality-control factors, such as UB...
Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance [0.03%]
由蛋白酶体依赖性调控的异染色质抑制因子Epe1截短介导抗真菌耐药性
Imtiyaz Yaseen,Sharon A White,Sito Torres-Garcia et al.
Imtiyaz Yaseen et al.
Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin, preventing it from spreading over, and silencing, gene-containing regions in fission yeast. External stress induces an adaptive response allowing heterochromatin...