Ciliary central apparatus structure reveals mechanisms of microtubule patterning [0.03%]
纤毛中央发生装置结构揭示了微管图案形成的机制
Miao Gui,Xiangli Wang,Susan K Dutcher et al.
Miao Gui et al.
A pair of extensively modified microtubules form the central apparatus (CA) of the axoneme of most motile cilia, where they regulate ciliary motility. The external surfaces of both CA microtubules are patterned asymmetrically with large pro...
Long Han,Qinhui Rao,Renbin Yang et al.
Long Han et al.
Accurately regulated ciliary beating in time and space is critical for diverse cellular activities, which impact the survival and development of nearly all eukaryotic species. An essential beating regulator is the conserved central apparatu...
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair [0.03%]
HMCESDNA-蛋白交联在DNA间链交联修复中作为中间体发挥作用
Daniel R Semlow,Victoria A MacKrell,Johannes C Walter
Daniel R Semlow
The 5-hydroxymethylcytosine binding, embryonic stem-cell-specific (HMCES) protein forms a covalent DNA-protein cross-link (DPC) with abasic (AP) sites in single-stranded DNA, and the resulting HMCES-DPC is thought to suppress double-strand ...
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins [0.03%]
线性链和低势能氢键在蛋白质结构与功能中的作用的真原子分辨率见解
Valentin Borshchevskiy,Kirill Kovalev,Ekaterina Round et al.
Valentin Borshchevskiy et al.
Hydrogen bonds are fundamental to the structure and function of biological macromolecules and have been explored in detail. The chains of hydrogen bonds (CHBs) and low-barrier hydrogen bonds (LBHBs) were proposed to play essential roles in ...
Single-stranded nucleic acid binding and coacervation by linker histone H1 [0.03%]
连接子组蛋白H1与单链核酸的结合及其凝聚作用
Rachel Leicher,Adewola Osunsade,Gabriella N L Chua et al.
Rachel Leicher et al.
The H1 linker histone family is the most abundant group of eukaryotic chromatin-binding proteins. However, their contribution to chromosome structure and function remains incompletely understood. Here we use single-molecule fluorescence and...
Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation [0.03%]
V-ATPase可逆解离过程中V1复合物的协调构象变化
Thamiya Vasanthakumar,Kristine A Keon,Stephanie A Bueler et al.
Thamiya Vasanthakumar et al.
Vacuolar-type ATPases (V-ATPases) are rotary enzymes that acidify intracellular compartments in eukaryotic cells. These multi-subunit complexes consist of a cytoplasmic V1 region that hydrolyzes ATP and a membrane-embedded VO region that tr...
Snapshots of actin and tubulin folding inside the TRiC chaperonin [0.03%]
捕捉TRiC分子伴侣中肌动蛋白和微管蛋白的折叠过程中的瞬间状态
John J Kelly,Dale Tranter,Els Pardon et al.
John J Kelly et al.
The integrity of a cell's proteome depends on correct folding of polypeptides by chaperonins. The chaperonin TCP-1 ring complex (TRiC) acts as obligate folder for >10% of cytosolic proteins, including he cytoskeletal proteins actin and tubu...
Author Correction: SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity [0.03%]
作者更正：类似SETDB1的MET-2在缺乏其H3K9三甲基化相关催化活性的情况下可独立促进转录沉默和发育
Colin E Delaney,Stephen P Methot,Veronique Kalck et al.
Colin E Delaney et al.
Published Erratum
Nature structural & molecular biology. 2022 May;29(5):502. DOI:10.1038/s41594-022-00776-w 2022
Keda Zhou,Magdalena Gebala,Dustin Woods et al.
Keda Zhou et al.
The histone variant CENP-A is the epigenetic determinant for the centromere, where it is interspersed with canonical H3 to form a specialized chromatin structure that nucleates the kinetochore. How nucleosomes at the centromere arrange into...