SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity [0.03%]
类似SETDB1的MET-2通过其H3K9三甲基化无关的催化活性促进转录沉默和发育
Colin E Delaney,Stephen P Methot,Veronique Kalck et al.
Colin E Delaney et al.
Transcriptionally silenced heterochromatin bearing methylation of histone H3 on lysine 9 (H3K9me) is critical for maintaining organismal viability and tissue integrity. Here we show that in addition to ensuring H3K9me, MET-2, the Caenorhabd...
Can AlphaFold2 predict the impact of missense mutations on structure? [0.03%]
AlphaFold2能否预测错义突变对结构的影响？
Gwen R Buel,Kylie J Walters
Gwen R Buel
ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy [0.03%]
ARN结合GTP酶活化沙门氏菌效应因子SopF以腺苷二磷酸核糖基化宿主V-ATP酶并抑制内膜损伤诱导的自噬作用
Yue Xu,Sen Cheng,Huan Zeng et al.
Yue Xu et al.
Selective autophagy helps eukaryotes to cope with endogenous dangers or foreign invaders; its initiation often involves membrane damage. By studying a Salmonella effector SopF, we recently identified the vacuolar ATPase (V-ATPase)-ATG16L1 a...
Tandem regulation of MutS activity by ATP and DNA during MMR initiation [0.03%]
ATP和DNA对MMR起始阶段中MutS活性的联合调节作用
Jean Baptiste Charbonnier
Jean Baptiste Charbonnier
IMPDH1 retinal variants control filament architecture to tune allosteric regulation [0.03%]
IMPDH1 视网膜变体控制丝状结构以调节别构调控
Anika L Burrell,Chuankai Nie,Meerit Said et al.
Anika L Burrell et al.
Inosine-5'-monophosphate dehydrogenase (IMPDH), a key regulatory enzyme in purine nucleotide biosynthesis, dynamically assembles filaments in response to changes in metabolic demand. Humans have two isoforms: IMPDH2 filaments reduce sensiti...
Alternative polyadenylation by sequential activation of distal and proximal PolyA sites [0.03%]
通过远端和近端多聚腺苷酸化位点的依次激活实现选择性多聚腺苷酸化
Peng Tang,Yang Yang,Guangnan Li et al.
Peng Tang et al.
Analogous to alternative splicing, alternative polyadenylation (APA) has long been thought to occur independently at proximal and distal polyA sites. Using fractionation-seq, we unexpectedly identified several hundred APA genes in human cel...
Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair [0.03%]
低温电子显微镜结构揭示了ATP和DNA结合如何协调MutS错配修复的顺序步骤
Alessandro Borsellini,Vladislav Kunetsky,Peter Friedhoff et al.
Alessandro Borsellini et al.
DNA mismatch repair detects and corrects mismatches introduced during DNA replication. The protein MutS scans for mismatches and coordinates the repair cascade. During this process, MutS undergoes multiple conformational changes in response...
Structure of the human cone photoreceptor cyclic nucleotide-gated channel [0.03%]
人眼锥体感光细胞环核苷酸门控离子通道的结构
Xiangdong Zheng,Zhengshan Hu,Huan Li et al.
Xiangdong Zheng et al.
Cyclic nucleotide-gated (CNG) channels transduce light-induced chemical signals into electrical signals in retinal cone and rod photoreceptors. Structures of native CNG channels, which are heterotetramers formed by CNGA and CNGB subunits, h...
The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods [0.03%]
牛视网膜杆细胞原生CNGA1/CNGB1 CNG通道的结构
Diane C A Barret,Gebhard F X Schertler,U Benjamin Kaupp et al.
Diane C A Barret et al.
In rod photoreceptors of the retina, the cyclic nucleotide-gated (CNG) channel is composed of three CNGA and one CNGB subunits, and it closes in response to light activation to generate an electrical signal that is conveyed to the brain. He...