Structural insights into binding of therapeutic channel blockers in NMDA receptors [0.03%]
治疗性通道阻滞剂与N-甲基-D天冬氨酸受体结合的结构洞察
Tsung-Han Chou,Max Epstein,Kevin Michalski et al.
Tsung-Han Chou et al.
Excitatory signaling mediated by N-methyl-D-aspartate receptor (NMDAR) is critical for brain development and function, as well as for neurological diseases and disorders. Channel blockers of NMDARs are of medical interest owing to their pot...
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies [0.03%]
通过在低复杂性蛋白质结构域中绘制突变来识别淀粉样蛋白相关疾病
Kevin A Murray,Michael P Hughes,Carolyn J Hu et al.
Kevin A Murray et al.
Proteins including FUS, hnRNPA2, and TDP-43 reversibly aggregate into amyloid-like fibrils through interactions of their low-complexity domains (LCDs). Mutations in LCDs can promote irreversible amyloid aggregation and disease. We introduce...
Mammalian PERIOD2 regulates H2A.Z incorporation in chromatin to orchestrate circadian negative feedback [0.03%]
哺乳动物PERIOD2通过调节组蛋白H2A.Z在染色质中的镶嵌来调控昼夜节律负反馈循环
Kevin Tartour,Francesca Andriani,Eric G Folco et al.
Kevin Tartour et al.
Mammalian circadian oscillators are built on a feedback loop in which the activity of the transcription factor CLOCK-BMAL1 is repressed by the PER-CRY complex. Here, we show that murine Per-/- fibroblasts display aberrant nucleosome occupan...
Allosteric regulation controls actin-bundling properties of human plastins [0.03%]
别构调节控制人类plastin的肌动蛋白聚集性质
Christopher L Schwebach,Elena Kudryashova,Richa Agrawal et al.
Christopher L Schwebach et al.
Plastins/fimbrins are conserved actin-bundling proteins contributing to motility, cytokinesis and other cellular processes by organizing strikingly different actin assemblies as in aligned bundles and branched networks. We propose that this...
Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory [0.03%]
组蛋白H1与核小体阵列的结合依赖于链接DNA的长度和轨迹
Marco Dombrowski,Maik Engeholm,Christian Dienemann et al.
Marco Dombrowski et al.
Throughout the genome, nucleosomes often form regular arrays that differ in nucleosome repeat length (NRL), occupancy of linker histone H1 and transcriptional activity. Here, we report cryo-EM structures of human H1-containing tetranucleoso...
Building a molecular rotor [0.03%]
构建分子转子
Florian Ullrich
Florian Ullrich
Carolina N Perdigoto
Carolina N Perdigoto
Beth Moorefield
Beth Moorefield
Elena A Zehr,Antonina Roll-Mecak
Elena A Zehr
Cryo-EM structure of the human CST-Polα/primase complex in a recruitment state [0.03%]
人类CST-Polα/原核复合物募集状态下的低温EM结构
Sarah W Cai,John C Zinder,Vladimir Svetlov et al.
Sarah W Cai et al.
The CST-Polα/primase complex is essential for telomere maintenance and functions to counteract resection at double-strand breaks. We report a 4.6-Å resolution cryo-EM structure of human CST-Polα/primase, captured prior to catalysis in a ...