Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome [0.03%]
SHOC2-MRAS-PP1C复合物的结构为RAF激活及Noonan综合征提供了新的见解
Daniel A Bonsor,Patrick Alexander,Kelly Snead et al.
Daniel A Bonsor et al.
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephospho...
Compartmentalization of the replication fork by single-stranded DNA-binding protein regulates translesion synthesis [0.03%]
单链DNA结合蛋白对复制叉的区室化调控跨损伤合成修复
Seungwoo Chang,Elizabeth S Thrall,Luisa Laureti et al.
Seungwoo Chang et al.
Processivity clamps tether DNA polymerases to DNA, allowing their access to the primer-template junction. In addition to DNA replication, DNA polymerases also participate in various genome maintenance activities, including translesion synth...
The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery [0.03%]
内核膜蛋白Lem2在核周RNA降解中的协调作用
Lucía Martín Caballero,Matías Capella,Ramón Ramos Barrales et al.
Lucía Martín Caballero et al.
Transcriptionally silent chromatin often localizes to the nuclear periphery. However, whether the nuclear envelope (NE) is a site for post-transcriptional gene repression is not well understood. Here we demonstrate that Schizosaccharomyces ...
Chromatin found in space [0.03%]
太空发现染色体
Carolina Perdigoto
Carolina Perdigoto
Matters of cell size [0.03%]
细胞大小的问题
Sara Osman
Sara Osman
Fabien Abdul,Aurélie Diman,Bastien Baechler et al.
Fabien Abdul et al.
In addition to its role in chromosome maintenance, the six-membered Smc5/6 complex functions as a restriction factor that binds to and transcriptionally silences viral and other episomal DNA. However, the underlying mechanism is unknown. He...
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1 [0.03%]
可视化由AAA-ATP酶Drg1从新生核糖体提取成熟因子的过程
Michael Prattes,Irina Grishkovskaya,Victor-Valentin Hodirnau et al.
Michael Prattes et al.
The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large ribosomal subunit. Drg1 releases the shuttling maturation factor Rlp24 from pre-60S particles shortly after nuclear exp...
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer [0.03%]
低聚糖负荷的mRNA转录本解析确定了肾癌中缺氧诱导因子和哺乳动物雷帕霉素靶点的失调交互作用
Yoichiro Sugimoto,Peter J Ratcliffe
Yoichiro Sugimoto
Hypoxia inducible factor (HIF) and mammalian target of rapamycin (mTOR) pathways orchestrate responses to oxygen and nutrient availability. These pathways are frequently dysregulated in cancer, but their interplay is poorly understood, in p...