Mechanism of cyclic β-glucan export by ABC transporter Cgt of Brucella [0.03%]
布鲁氏菌ABC转运蛋白Cgt输出环状β-葡聚糖的机制
Jaroslaw Sedzicki,Dongchun Ni,Frank Lehmann et al.
Jaroslaw Sedzicki et al.
Polysaccharides play critical roles in bacteria, including the formation of protective capsules and biofilms and establishing specific host cell interactions. Their transport across membranes is often mediated by ATP-binding cassette (ABC) ...
Jiangtao Zhang,Yiqiang Shi,Zhuo Huang et al.
Jiangtao Zhang et al.
Voltage-gated sodium channel NaV1.7 plays essential roles in pain and odor perception. NaV1.7 variants cause pain disorders. Accordingly, NaV1.7 has elicited extensive attention in developing new analgesics. Here we present cryo-EM structur...
Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II [0.03%]
RNA聚合酶II依赖SNAPc进行snRNA转录起始的结构基础
Srinivasan Rengachari,Sandra Schilbach,Thangavelu Kaliyappan et al.
Srinivasan Rengachari et al.
RNA polymerase II (Pol II) carries out transcription of both protein-coding and non-coding genes. Whereas Pol II initiation at protein-coding genes has been studied in detail, Pol II initiation at non-coding genes, such as small nuclear RNA...
Structures of transcription preinitiation complex engaged with the +1 nucleosome [0.03%]
与+1核小体结合的转录前起始复合物的结构
Haibo Wang,Sandra Schilbach,Momchil Ninov et al.
Haibo Wang et al.
The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed the PIC on different promoters, but did not address how...
Structure determination of inactive-state GPCRs with a universal nanobody [0.03%]
通用纳米体介导的无活性状态GPCR结构测定
Michael J Robertson,Makaía M Papasergi-Scott,Feng He et al.
Michael J Robertson et al.
Cryogenic electron microscopy (cryo-EM) has widened the field of structure-based drug discovery by allowing for routine determination of membrane protein structures previously intractable. Despite representing one of the largest classes of ...
Jing Luan,Marit W Vermunt,Camille M Syrett et al.
Jing Luan et al.
Transcription at most promoters is divergent, initiating at closely spaced oppositely oriented core promoters to produce sense transcripts along with often unstable upstream antisense transcripts (uasTrx). How antisense transcription is reg...
Atomic ribosome activity [0.03%]
原子核核糖体的活性
Jake Rogers
Jake Rogers
Katharine H Wrighton
Katharine H Wrighton
Tim Thomas
Tim Thomas
Rebecca Kelsey
Rebecca Kelsey