Exposing chromothripsis [0.03%]
揭秘染色体碎裂综合征
Carolina N Perdigoto
Carolina N Perdigoto
Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2 [0.03%]
-syncytin-2通过同步蛋白-2抑制神经酰胺脑摄取机制的结构见解
Maria Martinez-Molledo,Emmanuel Nji,Nicolas Reyes
Maria Martinez-Molledo
Brain development and function require uptake of essential omega-3 fatty acids in the form of lysophosphatidylcholine via major-facilitator superfamily transporter MFSD2A, a potential pharmaceutical target to modulate blood-brain barrier (B...
Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta [0.03%]
长链脂肪酸转运蛋白MFSD2A是大脑和胎盘的重要调节因子
Justin D Walter,Sille Remm,Markus A Seeger
Justin D Walter
MFSD2A mediates uptake of the essential fatty acid DHA across the blood–brain barrier. Separately, via interactions with syncytin-2, MFSD2A contributes to the formation of the mother–fetus placental boundary. Cryo-EM analysis of a human M...
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism [0.03%]
乙酰化循环通过PDS5A制动机制控制染色质环的长度
Marjon S van Ruiten,Démi van Gent,Ángela Sedeño Cacciatore et al.
Marjon S van Ruiten et al.
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin's SMC3 subunit is a dynamic process that involves the acetyltransferase ESCO1 and deacetylase H...
Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops [0.03%]
SMC3乙酰化、PDS5和SCC2控制建立凝聚素依赖性染色质环的转位酶活性
Nathalie Bastié,Christophe Chapard,Lise Dauban et al.
Nathalie Bastié et al.
Cohesin is a DNA translocase that is instrumental in the folding of the genome into chromatin loops, with functional consequences on DNA-related processes. Chromatin loop length and organization likely depend on cohesin processivity, transl...
Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential [0.03%]
筛选转录的编码和非编码区揭示RNA聚合酶II延长位点的序列决定因素
Hanneke Vlaming,Claudia A Mimoso,Andrew R Field et al.
Hanneke Vlaming et al.
Precise regulation of transcription by RNA polymerase II (RNAPII) is critical for organismal growth and development. However, what determines whether an engaged RNAPII will synthesize a full-length transcript or terminate prematurely is poo...
Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane [0.03%]
人类红细胞膜上锚蛋白复合物的结构、动力学和组装机制研究
Xian Xia,Shiheng Liu,Z Hong Zhou
Xian Xia
The cytoskeleton of a red blood cell (RBC) is anchored to the cell membrane by the ankyrin complex. This complex is assembled during RBC genesis and comprises primarily band 3, protein 4.2 and ankyrin, whose mutations contribute to numerous...
Quaternary structure independent folding of voltage-gated ion channel pore domain subunits [0.03%]
电压门控离子通道孔道结构域亚单位的四级结构独立折叠现象
Cristina Arrigoni,Marco Lolicato,David Shaya et al.
Cristina Arrigoni et al.
Every voltage-gated ion channel (VGIC) has a pore domain (PD) made from four subunits, each comprising an antiparallel transmembrane helix pair bridged by a loop. The extent to which PD subunit structure requires quaternary interactions is ...