Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development [0.03%]
作者更正：视黄酸信号在哺乳动物早期发育全能性窗口期至关重要
Ane Iturbide,Mayra L Ruiz Tejada Segura,Camille Noll et al.
Ane Iturbide et al.
Published Erratum
Nature structural & molecular biology. 2022 Mar;29(3):282. DOI:10.1038/s41594-022-00740-8 2022
Hongwei Zhang,Jiawei Su,Bin Li et al.
Hongwei Zhang et al.
Glycosylphosphatidylinositol (GPI) molecules are complex glycophospholipids and serve as membrane anchors for tethering many proteins to the cell surface. Attaching GPI to the protein in the endoplasmic reticulum (ER) is catalyzed by the tr...
Caillan Crowe-McAuliffe,Daniel N Wilson
Caillan Crowe-McAuliffe
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics [0.03%]
噁唑烷酮抗生素特异性抑制翻译的分子机制
Kaitlyn Tsai,Vanja Stojković,D John Lee et al.
Kaitlyn Tsai et al.
The antibiotic linezolid, the first clinically approved member of the oxazolidinone class, inhibits translation of bacterial ribosomes by binding to the peptidyl transferase center. Recent work has demonstrated that linezolid does not inhib...
Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol [0.03%]
氯霉素作为经典肽基转移酶抑制剂的作用机制及其结构基础
Egor A Syroegin,Laurin Flemmich,Dorota Klepacki et al.
Egor A Syroegin et al.
Ribosome-targeting antibiotics serve as powerful antimicrobials and as tools for studying the ribosome, the catalytic peptidyl transferase center (PTC) of which is targeted by many drugs. The classic PTC-acting antibiotic chloramphenicol (C...
Beth Moorefield
Beth Moorefield
Molting mitochondria [0.03%]
蜕皮的线粒体
Florian Ullrich
Florian Ullrich
Jinke Gu,Tianya Liu,Runyu Guo et al.
Jinke Gu et al.
Mammalian respiratory complex I (CI) is a 45-subunit, redox-driven proton pump that generates an electrochemical gradient across the mitochondrial inner membrane to power ATP synthesis in mitochondria. In the present study, we report cryo-e...
The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes [0.03%]
复杂素C端两性α-螺旋通过塑形膜来稳定融合孔的开放状态
Kevin C Courtney,Lanxi Wu,Taraknath Mandal et al.
Kevin C Courtney et al.
Neurotransmitter release is mediated by proteins that drive synaptic vesicle fusion with the presynaptic plasma membrane. While soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) form the core of the fusion appa...