Judith Barbara Zaugg,Pelin Sahlén,Robin Andersson et al.
Judith Barbara Zaugg et al.
Enhancers play a central role in the spatiotemporal control of gene expression and tend to work in a cell-type-specific manner. In addition, they are suggested to be major contributors to phenotypic variation, evolution and disease. There i...
Anne-Laure Valton,Sergey V Venev,Barbara Mair et al.
Anne-Laure Valton et al.
Cohesin-mediated loop extrusion has been shown to be blocked at specific cis-elements, including CTCF sites, producing patterns of loops and domain boundaries along chromosomes. Here we explore such cis-elements, and their role in gene regu...
A critical period of translational control during brain development at codon resolution [0.03%]
大脑发育过程中在密码子水平上进行翻译调控的关键时期
Dermot Harnett,Mateusz C Ambrozkiewicz,Ulrike Zinnall et al.
Dermot Harnett et al.
Translation modulates the timing and amplification of gene expression after transcription. Brain development requires uniquely complex gene expression patterns, but large-scale measurements of translation directly in the prenatal brain are ...
Katharine H Wrighton
Katharine H Wrighton
Tim Thomas
Tim Thomas
Joseph Willson
Joseph Willson
Sequence-specific remodeling of a topologically complex RNP substrate by Spb4 [0.03%]
Spb4对拓扑复杂RNP底物的特异性重塑
Victor Emmanuel Cruz,Kamil Sekulski,Nagesh Peddada et al.
Victor Emmanuel Cruz et al.
DEAD-box ATPases are ubiquitous enzymes essential in all aspects of RNA biology. However, the limited in vitro catalytic activities described for these enzymes are at odds with their complex cellular roles, most notably in driving large-sca...
Porter M Hall,James T Inman,Robert M Fulbright et al.
Porter M Hall et al.
CRISPR (clustered regularly interspaced short palindromic repeats) utility relies on a stable Cas effector complex binding to its target site. However, a Cas complex bound to DNA may be removed by motor proteins carrying out host processes ...
Aakash Basu,Dmitriy G Bobrovnikov,Basilio Cieza et al.
Aakash Basu et al.
Diverse DNA-deforming processes are impacted by the local mechanical and structural properties of DNA, which in turn depend on local sequence and epigenetic modifications. Deciphering this mechanical code (that is, this dependence) has been...
Babatunde Ekundayo,Davide Torre,Bertrand Beckert et al.
Babatunde Ekundayo et al.
The CRISPR-guided caspase (Craspase) complex is an assembly of the target-specific RNA nuclease known as Cas7-11 bound to CRISPR RNA (crRNA) and an ancillary protein known as TPR-CHAT (tetratricopeptide repeats (TPR) fused with a CHAT domai...