Pujuan Deng,Jun-Jie Gogo Liu
Pujuan Deng
Wen-Ting Lo,Yingyi Zhang,Oscar Vadas et al.
Wen-Ting Lo et al.
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) is an essential member of the structurally unresolved class II PI3K family with crucial functions in lipid signaling, endocytosis, angiogenesis, viral replication, platelet formation and a r...
The oxytocin signaling complex reveals a molecular switch for cation dependence [0.03%]
催产素信号复合物揭示了阳离子依赖的分子开关
Justin G Meyerowitz,Michael J Robertson,Ximena Barros-Álvarez et al.
Justin G Meyerowitz et al.
Oxytocin (OT) and vasopressin (AVP) are conserved peptide signaling hormones that are critical for diverse processes including osmotic homeostasis, reproduction, lactation and social interaction. OT acts through the oxytocin receptor (OTR),...
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes [0.03%]
SARS-CoV-2刺突蛋白开放三聚体构象的可逆转换使其暴露新颖表位
Shawn M Costello,Sophie R Shoemaker,Helen T Hobbs et al.
Shawn M Costello et al.
Current COVID-19 vaccines and many clinical diagnostics are based on the structure and function of the SARS-CoV-2 spike ectodomain. Using hydrogen-deuterium exchange monitored by mass spectrometry, we have uncovered that, in addition to the...
Michael J Robertson,Justin G Meyerowitz,Ouliana Panova et al.
Michael J Robertson et al.
Somatostatin is a signaling peptide that plays a pivotal role in physiologic processes relating to metabolism and growth through its actions at somatostatin receptors (SSTRs). Members of the SSTR subfamily, particularly SSTR2, are key drug ...
Henning Arlt,Xuewu Sui,Brayden Folger et al.
Henning Arlt et al.
Lipid droplets (LDs) form in the endoplasmic reticulum by phase separation of neutral lipids. This process is facilitated by the seipin protein complex, which consists of a ring of seipin monomers, with a yet unclear function. Here, we repo...
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state [0.03%]
不含核苷酸的Chd1染色质重塑复合物的单分子光镊研究及其对核小体的作用机制
Ilana M Nodelman,Sayan Das,Anneliese M Faustino et al.
Ilana M Nodelman et al.
Chromatin remodelers are ATP-dependent enzymes that reorganize nucleosomes within all eukaryotic genomes. Here we report a complex of the Chd1 remodeler bound to a nucleosome in a nucleotide-free state, determined by cryo-EM to 2.3 Å resol...
Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2 [0.03%]
哺乳动物Na+/H+交换器NHA2的结构、机制及脂质介导的重塑作用
Rei Matsuoka,Roman Fudim,Sukkyeong Jung et al.
Rei Matsuoka et al.
The Na+/H+ exchanger SLC9B2, also known as NHA2, correlates with the long-sought-after Na+/Li+ exchanger linked to the pathogenesis of diabetes mellitus and essential hypertension in humans. Despite the functional importance of NHA2, struct...
Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery [0.03%]
泛素连接酶Panoramix介导的染色质SUMO化连接piRNA途径和异染色质机器
Veselin I Andreev,Changwei Yu,Juncheng Wang et al.
Veselin I Andreev et al.
Nuclear Argonaute proteins, guided by small RNAs, mediate sequence-specific heterochromatin formation. The molecular principles that link Argonaute-small RNA complexes to cellular heterochromatin effectors on binding to nascent target RNAs ...
Yao Shen,Josue Gomez-Blanco,Michael T Petassi et al.
Yao Shen et al.
Tn7 transposable elements are unique for their highly specific, and sometimes programmable, target-site selection mechanisms and precise insertions. All the elements in the Tn7 family utilize an AAA+ adaptor (TnsC) to coordinate target-site...