Beth Moorefield
Beth Moorefield
Jie Li,Junhee Park,John P Mayer et al.
Jie Li et al.
Insulin receptor (IR) signaling controls multiple facets of animal physiology. Maximally four insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise functional roles of each binding event during IR activat...
Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization [0.03%]
AP2适配体-clathrin核小体结构调控内吞的分子机制研究
Edward A Partlow,Kevin S Cannon,Gunther Hollopeter et al.
Edward A Partlow et al.
Clathrin-mediated endocytosis (CME) is the main route of internalization from the plasma membrane. It is known that the heterotetrameric AP2 clathrin adaptor must open to simultaneously engage membrane and endocytic cargo, yet it is unclear...
Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging [0.03%]
HIV-1 5'-UTR的长程和短程相互作用调控基因组二聚化与包装
Liqing Ye,Anne-Sophie Gribling-Burrer,Patrick Bohn et al.
Liqing Ye et al.
RNA dimerization is the noncovalent association of two human immunodeficiency virus-1 (HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a prerequisite for binding to the viral structural protein Pr55Gag durin...
Structure of the human GlcNAc-1-phosphotransferase αβ subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation [0.03%]
人GlcNAc-1-磷酸转移酶αβ亚基结构揭示了溶酶体酶糖基磷酸化的调控机制
Hua Li,Wang-Sik Lee,Xiang Feng et al.
Hua Li et al.
Vertebrates use the mannose 6-phosphate (M6P)-recognition system to deliver lysosomal hydrolases to lysosomes. Key to this pathway is N-acetylglucosamine (GlcNAc)-1-phosphotransferase (PTase) that selectively adds GlcNAc-phosphate (P) to ma...
Bound nucleotide can control the dynamic architecture of monomeric actin [0.03%]
结合核苷酸可以控制单体肌动蛋白的动态结构
Rustam Ali,Jacob A Zahm,Michael K Rosen
Rustam Ali
Polymerization of actin into cytoskeletal filaments is coupled to its bound adenine nucleotides. The mechanism by which nucleotide modulates actin functions has not been evident from analyses of ATP- and ADP-bound crystal structures of the ...
PARP inhibition impedes the maturation of nascent DNA strands during DNA replication [0.03%]
DNA复制过程中，PARP抑制阻碍新生DNA链成熟
Alina Vaitsiankova,Kamila Burdova,Margarita Sobol et al.
Alina Vaitsiankova et al.
Poly(ADP-ribose) polymerase 1 (PARP1) is implicated in the detection and processing of unligated Okazaki fragments and other DNA replication intermediates, highlighting such structures as potential sources of genome breakage induced by PARP...
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation [0.03%]
去甲肾上腺素代谢物DOPEGAL对tau的修饰促使其病理和传播
Seong Su Kang,Lanxia Meng,Xingyu Zhang et al.
Seong Su Kang et al.
The noradrenergic locus ceruleus (LC) is the first site of detectable tau pathology in Alzheimer's disease (AD), but the mechanisms underlying the selective vulnerability of the LC in AD have not been completely identified. In the present s...
Juan C Castaneda,Marina Schrecker,Dirk Remus et al.
Juan C Castaneda et al.
Single-stranded or double-stranded DNA junctions with recessed 5' ends serve as loading sites for the checkpoint clamp, 9-1-1, which mediates activation of the apical checkpoint kinase, ATRMec1. However, the basis for 9-1-1's recruitment to...
DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp [0.03%]
DNA通过复制应激检查点钳9-1-1的方向与PCNA相反
Fengwei Zheng,Roxana E Georgescu,Nina Y Yao et al.
Fengwei Zheng et al.
The 9-1-1 DNA checkpoint clamp is loaded onto 5'-recessed DNA to activate the DNA damage checkpoint that arrests the cell cycle. The 9-1-1 clamp is a heterotrimeric ring that is loaded in Saccharomyces cerevisiae by Rad24-RFC (hRAD17-RFC), ...