Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits [0.03%]
具有GluN2C和GluN2D亚基的多样化NMDA受体的不同结构和门控机制
Jilin Zhang,Ming Zhang,Qinrui Wang et al.
Jilin Zhang et al.
N-methyl-D-aspartate (NMDA) receptors are heterotetramers comprising two GluN1 and two alternate GluN2 (N2A-N2D) subunits. Here we report full-length cryo-EM structures of the human N1-N2D di-heterotetramer (di-receptor), rat N1-N2C di-rece...
Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis [0.03%]
H3K9三甲基化丧失可改变有丝分裂中的染色体凝集和转录因子滞留
Dounia Djeghloul,Andrew Dimond,Sherry Cheriyamkunnel et al.
Dounia Djeghloul et al.
Recent studies have shown that repressive chromatin machinery, including DNA methyltransferases and polycomb repressor complexes, binds to chromosomes throughout mitosis and their depletion results in increased chromosome size. In the prese...
Dimitris Typas
Dimitris Typas
Sara Osman
Sara Osman
Katarzyna Ciazynska
Katarzyna Ciazynska
Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels [0.03%]
LRRC8A:C容积调节阴离子通道的组装和脂质门控结构基础
David M Kern,Julia Bleier,Somnath Mukherjee et al.
David M Kern et al.
Leucine-rich repeat-containing protein 8 (LRRC8) family members form volume-regulated anion channels activated by hypoosmotic cell swelling. LRRC8 channels are ubiquitously expressed in vertebrate cells as heteromeric assemblies of LRRC8A (...
Pierre Barraud,Carine Tisné
Pierre Barraud
Heterochromatin rewiring and domain disruption-mediated chromatin compaction during erythropoiesis [0.03%]
红细胞生成过程中异染色质重构和功能域解体介导的染色质凝聚
Dong Li,Fan Wu,Shuo Zhou et al.
Dong Li et al.
Mammalian erythropoiesis involves progressive chromatin compaction and subsequent enucleation in terminal differentiation, but the mechanisms underlying the three-dimensional chromatin reorganization remain obscure. Here, we systematically ...
R J McGinty,S R Sunyaev
R J McGinty
Non-B DNA structures formed by repetitive sequence motifs are known instigators of mutagenesis in experimental systems. Analyzing this phenomenon computationally in the human genome requires careful disentangling of intrinsic confounding fa...
Long Han,Qinhui Rao,Renbin Yang et al.
Long Han et al.
Published Erratum
Nature structural & molecular biology. 2023 Apr;30(4):564. DOI:10.1038/s41594-023-00961-5 2023