Author Correction: Plasticity in ligand recognition at somatostatin receptors [0.03%]
作者更正： somatostatin 受体的配体识别的可塑性
Michael J Robertson,Justin G Meyerowitz,Ouliana Panova et al.
Michael J Robertson et al.
Published Erratum
Nature structural & molecular biology. 2022 Aug;29(8):841. DOI:10.1038/s41594-022-00813-8 2022
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans [0.03%]
白色念珠菌几丁质合成酶的抑制和调节作用的结构基础
Zhenning Ren,Abhishek Chhetri,Ziqiang Guan et al.
Zhenning Ren et al.
Chitin is an essential component of the fungal cell wall. Chitin synthases (Chss) catalyze chitin formation and translocation across the membrane and are targets of antifungal agents, including nikkomycin Z and polyoxin D. Lack of structura...
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening [0.03%]
端粒缺失缩短情况下，端粒8-氧鸟嘌呤驱动细胞快速衰老
Ryan P Barnes,Mariarosaria de Rosa,Sanjana A Thosar et al.
Ryan P Barnes et al.
Oxidative stress is a primary cause of cellular senescence and contributes to the etiology of numerous human diseases. Oxidative damage to telomeric DNA has been proposed to cause premature senescence by accelerating telomere shortening. He...
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels [0.03%]
来自单细胞藻类的视紫红质- bestatin融合蛋白形成巨大的五聚体离子通道
Andrey Rozenberg,Igor Kaczmarczyk,Donna Matzov et al.
Andrey Rozenberg et al.
Many organisms sense light using rhodopsins, photoreceptive proteins containing a retinal chromophore. Here we report the discovery, structure and biophysical characterization of bestrhodopsins, a microbial rhodopsin subfamily from marine u...
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes [0.03%]
构建调控景观揭示了增强子能够募集粘连素以创建接触域、参与CTCF位点并激活远处基因
Niels J Rinzema,Konstantinos Sofiadis,Sjoerd J D Tjalsma et al.
Niels J Rinzema et al.
Developmental gene expression is often controlled by distal regulatory DNA elements called enhancers. Distant enhancer action is restricted to structural chromosomal domains that are flanked by CTCF-associated boundaries and formed through ...
Exposing chromothripsis [0.03%]
揭秘染色体碎裂综合征
Carolina N Perdigoto
Carolina N Perdigoto
Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2 [0.03%]
-syncytin-2通过同步蛋白-2抑制神经酰胺脑摄取机制的结构见解
Maria Martinez-Molledo,Emmanuel Nji,Nicolas Reyes
Maria Martinez-Molledo
Brain development and function require uptake of essential omega-3 fatty acids in the form of lysophosphatidylcholine via major-facilitator superfamily transporter MFSD2A, a potential pharmaceutical target to modulate blood-brain barrier (B...
Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta [0.03%]
长链脂肪酸转运蛋白MFSD2A是大脑和胎盘的重要调节因子
Justin D Walter,Sille Remm,Markus A Seeger
Justin D Walter
MFSD2A mediates uptake of the essential fatty acid DHA across the blood–brain barrier. Separately, via interactions with syncytin-2, MFSD2A contributes to the formation of the mother–fetus placental boundary. Cryo-EM analysis of a human M...