Dimitris Typas
Dimitris Typas
Sara Osman
Sara Osman
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition [0.03%]
通过多聚（A）尾部对母系mRNA的改造调控人类卵母细胞向胚胎的转变
Yusheng Liu,Han Zhao,Fanghong Shao et al.
Yusheng Liu et al.
Poly(A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in the oocyte-to-embryo transition (OET). Nothing is known about poly(A) tail dynamics during the human OET. Here, we show that poly(A) tail length and interna...
Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3 [0.03%]
由SYCE3调控的SYCP1介导的减数分裂染色体联会的结构成熟过程
James H Crichton,James M Dunce,Orla M Dunne et al.
James H Crichton et al.
In meiosis, a supramolecular protein structure, the synaptonemal complex (SC), assembles between homologous chromosomes to facilitate their recombination. Mammalian SC formation is thought to involve hierarchical zipper-like assembly of an ...
Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis [0.03%]
钙调蛋白激活志贺氏菌效应因子OspC3的结构机制，ADP核糖化caspase-4/11并阻断焦亡过程
Yanjie Hou,Huan Zeng,Zilin Li et al.
Yanjie Hou et al.
The caspase-4/11-GSDMD pyroptosis axis recognizes cytosolic lipopolysaccharide for antibacterial defenses. Shigella flexneri employs an OspC3 effector to block pyroptosis by catalyzing NAD+-dependent arginine ADP-riboxanation of caspase-4/1...
Brominated lipid probes expose structural asymmetries in constricted membranes [0.03%]
溴化的脂质探针揭示了受限制膜结构中的不对称性
Frank R Moss rd,James Lincoff,Maxwell Tucker et al.
Frank R Moss rd et al.
Lipids in biological membranes are thought to be functionally organized, but few experimental tools can probe nanoscale membrane structure. Using brominated lipids as contrast probes for cryo-EM and a model ESCRT-III membrane-remodeling sys...
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly [0.03%]
HIV-1依赖其未成熟的格子来募集IP6以完成成熟的核心组装
Nadine Renner,Alex Kleinpeter,Donna L Mallery et al.
Nadine Renner et al.
HIV-1 Gag metamorphoses inside each virion, from an immature lattice that forms during viral production to a mature capsid that drives infection. Here we show that the immature lattice is required to concentrate the cellular metabolite inos...
Hironori Takeda,Jon V Busto,Caroline Lindau et al.
Hironori Takeda et al.
Mitochondrial β-barrel proteins are essential for the transport of metabolites, ions and proteins. The sorting and assembly machinery (SAM) mediates their folding and membrane insertion. We report the cryo-electron microscopy structure of ...
Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5 [0.03%]
冷冻电镜解析无配基NAIP5结构揭示了NAIP-NLRC4炎性小体激活的机制
Bhaskar Paidimuddala,Jianhao Cao,Grady Nash et al.
Bhaskar Paidimuddala et al.
The nucleotide-binding domain (NBD), leucine rich repeat (LRR) domain containing protein family (NLR family) apoptosis inhibitory proteins (NAIPs) are cytosolic receptors that play critical roles in the host defense against bacterial infect...
Shikang Liang,Tom L Blundell
Shikang Liang
DNA-dependent protein kinase (DNA-PK), a multicomponent complex including the DNA-PK catalytic subunit and Ku70/80 heterodimer together with DNA, is central to human DNA damage response and repair. Using a DNA-PK-selective inhibitor (M3814)...