Kelli L Hvorecny,Kenzee Hargett,Joel D Quispe et al.
Kelli L Hvorecny et al.
The universally conserved enzyme phosphoribosyl pyrophosphate synthetase (PRPS) assembles filaments in evolutionarily diverse organisms. PRPS is a key regulator of nucleotide metabolism, and mutations in the human enzyme PRPS1 lead to a spe...
Signal-induced enhancer activation requires Ku70 to read topoisomerase1-DNA covalent complexes [0.03%]
信号诱导的增强子激活需要Ku70来识别拓扑异构酶1-DNA共价复合物
Yuliang Tan,Lu Yao,Amir Gamliel et al.
Yuliang Tan et al.
Enhancer activation serves as the main mechanism regulating signal-dependent transcriptional programs, ensuring cellular plasticity, yet central questions persist regarding their mechanism of activation. Here, by successfully mapping topois...
Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication [0.03%]
四聚体糖皮质激素受体结构揭示别构跨域通讯
Sandra Postel,Lisa Wissler,Carina A Johansson et al.
Sandra Postel et al.
The glucocorticoid receptor (GR) is a ligand-activated transcription factor that binds DNA and assembles co-regulator complexes to regulate gene transcription. GR agonists are widely prescribed to people with inflammatory and autoimmune dis...
Patrick Schultz
Patrick Schultz
CRISPR-Cas has a new juggling act: interplay between nuclease and protease [0.03%]
CRISPR-Cas有了新玩法：核酸酶与蛋白酶的相互作用
Anthony D Rish,Tian-Min Fu
Anthony D Rish
EGOC inhibits TOROID polymerization by structurally activating TORC1 [0.03%]
EGOC通过结构活化TORC1抑制TOROID聚合
Manoël Prouteau,Clélia Bourgoint,Jan Felix et al.
Manoël Prouteau et al.
Target of rapamycin complex 1 (TORC1) is a protein kinase controlling cell homeostasis and growth in response to nutrients and stresses. In Saccharomyces cerevisiae, glucose depletion triggers a redistribution of TORC1 from a dispersed loca...
Author Correction: Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5 [0.03%]
作者更正：通过未结合配体的NAIP5的低温电镜结构揭示NAIP-NLRC4炎性小体激活机制
Bhaskar Paidimuddala,Jianhao Cao,Grady Nash et al.
Bhaskar Paidimuddala et al.
Published Erratum
Nature structural & molecular biology. 2023 Feb;30(2):233. DOI:10.1038/s41594-023-00927-7 2023
Author Correction: A multipoint guidance mechanism for β-barrel folding on the SAM complex [0.03%]
作者更正：SAM 复合物上β- barrels 投稿的多点指导机制
Hironori Takeda,Jon V Busto,Caroline Lindau et al.
Hironori Takeda et al.
Published Erratum
Nature structural & molecular biology. 2023 Feb;30(2):233. DOI:10.1038/s41594-023-00926-8 2023
David F Burke,Patrick Bryant,Inigo Barrio-Hernandez et al.
David F Burke et al.
Cellular functions are governed by molecular machines that assemble through protein-protein interactions. Their atomic details are critical to studying their molecular mechanisms. However, fewer than 5% of hundreds of thousands of human pro...
Two rings to fold them [0.03%]
两个环来折叠它们
Katarzyna Ciazynska
Katarzyna Ciazynska