Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate [0.03%]
磷酸化和葡萄糖-6-磷酸的人糖原合酶调节的分子基础
Thomas J McCorvie,Paula M Loria,Meihua Tu et al.
Thomas J McCorvie et al.
Glycogen synthase (GYS1) is the central enzyme in muscle glycogen biosynthesis. GYS1 activity is inhibited by phosphorylation of its amino (N) and carboxyl (C) termini, which is relieved by allosteric activation of glucose-6-phosphate (Glc6...
Domenic N Narducci,Anders S Hansen
Domenic N Narducci
Structural maintenance of chromosomes (SMC) complexes such as condensin regulate chromosome organization by extruding loops. A new study uses single-molecule imaging of condensin on supercoiled DNA to understand how condensins navigate the ...
Ashley M Toye
Ashley M Toye
Inactive and active state structures template selective tools for the human 5-HT5A receptor [0.03%]
人类5-羟色胺5A受体的非活性和活性构象模板选择工具
Shicheng Zhang,He Chen,Chengwei Zhang et al.
Shicheng Zhang et al.
Serotonin receptors are important targets for established therapeutics and drug development as they are expressed throughout the human body and play key roles in cell signaling. There are 12 serotonergic G protein-coupled receptor members e...
Kinetic principles underlying pioneer function of GAGA transcription factor in live cells [0.03%]
GAGA转录因子在活细胞中作为拓殖因子的动力学原理
Xiaona Tang,Taibo Li,Sheng Liu et al.
Xiaona Tang et al.
How pioneer factors interface with chromatin to promote accessibility for transcription control is poorly understood in vivo. Here, we directly visualize chromatin association by the prototypical GAGA pioneer factor (GAF) in live Drosophila...
Francesca Vallese,Kookjoo Kim,Laura Y Yen et al.
Francesca Vallese et al.
The stability and shape of the erythrocyte membrane is provided by the ankyrin-1 complex, but how it tethers the spectrin-actin cytoskeleton to the lipid bilayer and the nature of its association with the band 3 anion exchanger and the Rhes...
Eugene Kim,Alejandro Martin Gonzalez,Biswajit Pradhan et al.
Eugene Kim et al.
Condensin, a structural maintenance of chromosomes (SMC) complex, has been shown to be a molecular motor protein that organizes chromosomes by extruding loops of DNA. In cells, such loop extrusion is challenged by many potential conflicts, ...
Parkinson's disease risk protein TMEM175 keeps lysosomes running on a proton leak [0.03%]
帕金森病风险蛋白TMEM175通过质子泄漏维持溶酶体功能
Carolina N Perdigoto
Carolina N Perdigoto
Yang Yue,Lier Liu,Li-Jie Wu et al.
Yang Yue et al.
The technique of cryogenic-electron microscopy (cryo-EM) has revolutionized the field of membrane protein structure and function with a focus on the dominantly observed molecular species. This report describes the structural characterizatio...