Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing [0.03%]
干扰RNA剪接的近外显子内含子变异体的作用机制及建模研究人类疾病相关变异体
Hung-Lun Chiang,Yi-Ting Chen,Jia-Ying Su et al.
Hung-Lun Chiang et al.
It is estimated that 10%-30% of disease-associated genetic variants affect splicing. Splicing variants may generate deleteriously altered gene product and are potential therapeutic targets. However, systematic diagnosis or prediction of spl...
Author Correction: It's not just a phase: function and characteristics of RNA-binding proteins in phase separation [0.03%]
作者更正：RNA结合蛋白在相分离中的功能和特征并非只是一个阶段
Hannah J Wiedner,Jimena Giudice
Hannah J Wiedner
Published Erratum
Nature structural & molecular biology. 2022 Nov;29(11):1145. DOI:10.1038/s41594-022-00876-7 2022
Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker [0.03%]
帕金森病患者位点结构蛋白质组的全球原位分析以识别新型生物标志物亚群
Marie-Therese Mackmull,Luise Nagel,Fabian Sesterhenn et al.
Marie-Therese Mackmull et al.
Parkinson's disease (PD) is a prevalent neurodegenerative disease for which robust biomarkers are needed. Because protein structure reflects function, we tested whether global, in situ analysis of protein structural changes provides insight...
Distinct roles for CKM-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction [0.03%]
CKM-中介体在控制Polycomb依赖的染色体重塑和启动基因诱导中的不同作用
Emilia Dimitrova,Angelika Feldmann,Robin H van der Weide et al.
Emilia Dimitrova et al.
Precise control of gene expression underpins normal development. This relies on mechanisms that enable communication between gene promoters and other regulatory elements. In embryonic stem cells (ESCs), the cyclin-dependent kinase module Me...
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution [0.03%]
MiOS：一种整合影像与计算策略，以核小体分辨率建模基因折叠效应
Maria Victoria Neguembor,Juan Pablo Arcon,Diana Buitrago et al.
Maria Victoria Neguembor et al.
The linear sequence of DNA provides invaluable information about genes and their regulatory elements along chromosomes. However, to fully understand gene function and regulation, we need to dissect how genes physically fold in the three-dim...
Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation [0.03%]
线粒体细胞色素c核转位通过改变核糖体液-液相分离释放与核仁结合蛋白NPM1结合的肿瘤抑制因子ARF
Katiuska González-Arzola,Antonio Díaz-Quintana,Noelia Bernardo-García et al.
Katiuska González-Arzola et al.
The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet cytochrome c (Cc) migrates to the nucleus and even the nucleolus under stress conditions. Nucleolar liquid-liquid phase sepa...
A quick fix for lysosomes [0.03%]
细胞溶酶体快速修复方案
Katharine H Wrighton
Katharine H Wrighton
Joseph Willson
Joseph Willson
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction [0.03%]
PKA抑制基序通过SMO控制Hh信号转导
John T Happ,Corvin D Arveseth,Jessica Bruystens et al.
John T Happ et al.
The Hedgehog (Hh) cascade is central to development, tissue homeostasis and cancer. A pivotal step in Hh signal transduction is the activation of glioma-associated (GLI) transcription factors by the atypical G protein-coupled receptor (GPCR...