Katarina Meze,Armend Axhemi,Dennis R Thomas et al.
Katarina Meze et al.
RNA turnover pathways ensure appropriate gene expression levels by eliminating unwanted transcripts. Dis3-like 2 (Dis3L2) is a 3'-5' exoribonuclease that plays a critical role in human development. Dis3L2 independently degrades structured s...
Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels [0.03%]
具有核孔复合体 gated DNA-Origami 通道的 HIV-1 核输入建模
Qi Shen,Qingzhou Feng,Chunxiang Wu et al.
Qi Shen et al.
Delivering the virus genome into the host nucleus through the nuclear pore complex (NPC) is pivotal in human immunodeficiency virus 1 (HIV-1) infection. The mechanism of this process remains mysterious owing to the NPC complexity and the la...
Nazim Bouatta,Mohammed AlQuraishi
Nazim Bouatta
AlphaFold2 has already changed structural biology but its true power may lie in how it changes the way we think about cells and organisms. Two studies broadly analyze and assess the performance of AlphaFold2 to outline the extent of its uti...
The activated inflammasome [0.03%]
活化的炎性小体
Katarzyna Ciazynska
Katarzyna Ciazynska
Sara Osman
Sara Osman
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13 [0.03%]
必要内源性分支杆菌聚酮合成酶Pks13的结构与动态变化机制
Sun Kyung Kim,Miles Sasha Dickinson,Janet Finer-Moore et al.
Sun Kyung Kim et al.
The mycolic acid layer of the Mycobacterium tuberculosis cell wall is essential for viability and virulence, and the enzymes responsible for its synthesis are targets for antimycobacterial drug development. Polyketide synthase 13 (Pks13) is...
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas [0.03%]
胞内菌胆固醇和其他重要脂质的供应者P116蛋白
Lasse Sprankel,David Vizarraga,Jesús Martín et al.
Lasse Sprankel et al.
Mycoplasma pneumoniae, responsible for approximately 30% of community-acquired human pneumonia, needs to extract lipids from the host environment for survival and proliferation. Here, we report a comprehensive structural and functional anal...
Dimitris Typas
Dimitris Typas
A molecular switch modulates assembly and host factor binding of the HIV-1 capsid [0.03%]
一个分子开关可调节HIV-1衣壳的装配和宿主因子结合
Randall T Schirra,Nayara F B Dos Santos,Kaneil K Zadrozny et al.
Randall T Schirra et al.
The HIV-1 capsid is a fullerene cone made of quasi-equivalent hexamers and pentamers of the viral CA protein. Typically, quasi-equivalent assembly of viral capsid subunits is controlled by a molecular switch. Here, we identify a Thr-Val-Gly...