Long Han,Qinhui Rao,Renbin Yang et al.
Long Han et al.
Published Erratum
Nature structural & molecular biology. 2023 Apr;30(4):564. DOI:10.1038/s41594-023-00961-5 2023
cGAMP-activated cGAS-STING signaling: its bacterial origins and evolutionary adaptation by metazoans [0.03%]
由细菌起源并通过真核生物进化的cGAMP激活的cGAS-STING信号通路
Dinshaw J Patel,You Yu,Wei Xie
Dinshaw J Patel
The metazoan cGAMP-activated cGAS-STING innate immunity pathway is triggered in response to genomic instability and DNA damage, thereby providing host defense against microbial pathogens. This pathway also impacts on autophagy, cellular sen...
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres [0.03%]
RPA相分离的高亲和力单链DNA结合及端粒处动态凝聚功能属性
Vincent Spegg,Andreas Panagopoulos,Merula Stout et al.
Vincent Spegg et al.
RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is required for downstream ssDNA transactions. How ultrahigh-affinity b...
ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells [0.03%]
自动取款机信号调节了减数分裂偶线期和增殖细胞中cohesin的行为方式
Zhouliang Yu,Hyung Jun Kim,Abby F Dernburg
Zhouliang Yu
Cohesins are ancient and ubiquitous regulators of chromosome architecture and function, but their diverse roles and regulation remain poorly understood. During meiosis, chromosomes are reorganized as linear arrays of chromatin loops around ...
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence [0.03%]
作者更正：O-连接的糖基转移酶活性部位对其底物序列有一定的约束作用
Shalini Pathak,Jana Alonso,Marianne Schimpl et al.
Shalini Pathak et al.
Published Erratum
Nature structural & molecular biology. 2023 Apr;30(4):564. DOI:10.1038/s41594-023-00945-5 2023
Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids [0.03%]
直接可视化转录-复制冲突可揭示后复制品DNA：RNA杂交体
Henriette Stoy,Katharina Zwicky,Danina Kuster et al.
Henriette Stoy et al.
Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-loops were linked to head-on TRCs and proposed to obstruct replication fork progression. The underlying mechanisms, however, remained elusive due ...
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity [0.03%]
外显子1的病原性亨廷顿蛋白结构定义了其聚集趋势的基础
Carlos A Elena-Real,Amin Sagar,Annika Urbanek et al.
Carlos A Elena-Real et al.
Huntington's disease is a neurodegenerative disorder caused by a CAG expansion in the first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin (httex1). The structural changes occurring to the poly-Q w...
Chunxiang Wu,Yong Xiong
Chunxiang Wu
Recent studies offer new insight on the mechanisms of IP6-mediated HIV-1 capsid assembly. The immature Gag lattice enables enrichment of IP6 into virions, aiding capsid maturation. Structures of capsid protein (CA) assemblies reveal motifs ...
Short poly(A) tails are protected from deadenylation by the LARP1-PABP complex [0.03%]
短聚腺苷酸尾丝通过LARP1-PABP复合物免受去多腺苷酸化保护
Joha Park,Myeonghwan Kim,Hyerim Yi et al.
Joha Park et al.
Deadenylation generally constitutes the first and pivotal step in eukaryotic messenger RNA decay. Despite its importance in posttranscriptional regulations, the kinetics of deadenylation and its regulation remain largely unexplored. Here we...
Author Correction: Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging [0.03%]
作者更正：HIV-1 5' UTR 中的短程和长程相互作用调节基因组二聚化和包装
Liqing Ye,Anne-Sophie Gribling-Burrer,Patrick Bohn et al.
Liqing Ye et al.
Published Erratum
Nature structural & molecular biology. 2023 Mar;30(3):403. DOI:10.1038/s41594-023-00946-4 2023