Caroline Barranco
Caroline Barranco
Autophagosomes need calcium [0.03%]
自噬体需要钙离子
Lucia Brunello
Lucia Brunello
Anionic lipids unlock the gates of select ion channels in the pacemaker family [0.03%]
阴性脂质解锁起搏器家族选择离子通道的闸门
Philipp A M Schmidpeter,Di Wu,Jan Rheinberger et al.
Philipp A M Schmidpeter et al.
Lipids play important roles in regulating membrane protein function, but the molecular mechanisms used are elusive. Here we investigated how anionic lipids modulate SthK, a bacterial pacemaker channel homolog, and HCN2, whose activity contr...
An atypical RNA quadruplex marks RNAs as vectors for gene silencing [0.03%]
一个非典型的RNA四链体标记RNA作为基因沉默的载体
Saeed Roschdi,Jenny Yan,Yuichiro Nomura et al.
Saeed Roschdi et al.
The addition of poly(UG) ('pUG') repeats to 3' termini of mRNAs drives gene silencing and transgenerational epigenetic inheritance in the metazoan Caenorhabditis elegans. pUG tails promote silencing by recruiting an RNA-dependent RNA polyme...
Mehmet Akdel,Douglas E V Pires,Eduard Porta Pardo et al.
Mehmet Akdel et al.
Most proteins fold into 3D structures that determine how they function and orchestrate the biological processes of the cell. Recent developments in computational methods for protein structure predictions have reached the accuracy of experim...
Jason Gorman,Chunyan Wang,Rosemarie D Mason et al.
Jason Gorman et al.
Simian immunodeficiency viruses (SIVs) are lentiviruses that naturally infect non-human primates of African origin and seeded cross-species transmissions of HIV-1 and HIV-2. Here we report prefusion stabilization and cryo-EM structures of s...
The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer [0.03%]
转录终止子XRN2和RNA结合蛋白Sam68将前列腺癌中的可变多聚腺苷酸化与细胞周期进展联系起来
Marco Pieraccioli,Cinzia Caggiano,Luca Mignini et al.
Marco Pieraccioli et al.
Alternative polyadenylation (APA) yields transcripts differing in their 3'-end, and its regulation is altered in cancer, including prostate cancer. Here we have uncovered a mechanism of APA regulation impinging on the interaction between th...
Switching under selection: how CoREST controls endocrine therapy resistance in ER+ breast cancer [0.03%]
在选择压力下的切换：CoREST如何控制ER阳性乳腺癌的内分泌治疗抗性
Brent Y Chick,Diana C Hargreaves
Brent Y Chick
Endocrine resistance and breast cancer plasticity are controlled by CoREST [0.03%]
CoREST控制内分泌抵抗和乳腺癌的可塑性
Liliana Garcia-Martinez,Andrew M Adams,Ho Lam Chan et al.
Liliana Garcia-Martinez et al.
Resistance to cancer treatment remains a major clinical hurdle. Here, we demonstrate that the CoREST complex is a key determinant of endocrine resistance and ER+ breast cancer plasticity. In endocrine-sensitive cells, CoREST is recruited to...
AAA+ protease-adaptor structures reveal altered conformations and ring specialization [0.03%]
AAA+蛋白酶-适配器结构揭示了构象的改变和环的特化
Sora Kim,Xue Fei,Robert T Sauer et al.
Sora Kim et al.
ClpAP, a two-ring AAA+ protease, degrades N-end-rule proteins bound by the ClpS adaptor. Here we present high-resolution cryo-EM structures of Escherichia coli ClpAPS complexes, showing how ClpA pore loops interact with the ClpS N-terminal ...