Cody M Rogers,Patrick Sung
Cody M Rogers
Histone deacetylation primes self-propagation of heterochromatin domains to promote epigenetic inheritance [0.03%]
组蛋白去乙酰化促进异染色质域的自我传播以促进表观遗传学继承
Martin Zofall,Rima Sandhu,Sahana Holla et al.
Martin Zofall et al.
Heterochromatin assembly, involving histone H3 lysine-9 methylation (H3K9me), is nucleated at specific genomic sites but can self-propagate across extended domains and, indeed, generations. Self-propagation requires Clr4/Suv39h methyltransf...
The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination [0.03%]
DNA损伤激酶ATR通过泛素化起始激活FANCD2-FANCI滑动夹复合体
Tamara Sijacki,Pablo Alcón,Zhuo A Chen et al.
Tamara Sijacki et al.
DNA interstrand cross-links are tumor-inducing lesions that block DNA replication and transcription. When cross-links are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FAN...
Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation [0.03%]
CRL7FBXW8 结构揭示了与 CUL1-RBX1/ROC1 耦合以催化多 cullin-RING E3 泛素连接酶的机制
Linus V M Hopf,Kheewoong Baek,Maren Klügel et al.
Linus V M Hopf et al.
Most cullin-RING ubiquitin ligases (CRLs) form homologous assemblies between a neddylated cullin-RING catalytic module and a variable substrate-binding receptor (for example, an F-box protein). However, the vertebrate-specific CRL7FBXW8 is ...
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119 [0.03%]
孤儿受体GPR119的活化配体溶血磷脂酰胆碱的结构鉴定
Peiyu Xu,Sijie Huang,Shimeng Guo et al.
Peiyu Xu et al.
Lysophosphatidylcholine (LPC) is an essential mediator in human lipid metabolism and is associated with a variety of diseases, but the exact identity of LPC receptors remains controversial. Through extensive biochemical and structural analy...
Sara Osman
Sara Osman
Carolina N Perdigoto
Carolina N Perdigoto
Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST [0.03%]
填补空白：端粒酶通过CST追赶G链以完成染色体末端DNA复制
Conner L Olson,Alexandra T Barbour,Deborah S Wuttke
Conner L Olson
Jesús R Requena
Jesús R Requena