The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery [0.03%]
内核膜蛋白Lem2在核周RNA降解中的协调作用
Lucía Martín Caballero,Matías Capella,Ramón Ramos Barrales et al.
Lucía Martín Caballero et al.
Transcriptionally silent chromatin often localizes to the nuclear periphery. However, whether the nuclear envelope (NE) is a site for post-transcriptional gene repression is not well understood. Here we demonstrate that Schizosaccharomyces ...
Chromatin found in space [0.03%]
太空发现染色体
Carolina Perdigoto
Carolina Perdigoto
Matters of cell size [0.03%]
细胞大小的问题
Sara Osman
Sara Osman
Fabien Abdul,Aurélie Diman,Bastien Baechler et al.
Fabien Abdul et al.
In addition to its role in chromosome maintenance, the six-membered Smc5/6 complex functions as a restriction factor that binds to and transcriptionally silences viral and other episomal DNA. However, the underlying mechanism is unknown. He...
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1 [0.03%]
可视化由AAA-ATP酶Drg1从新生核糖体提取成熟因子的过程
Michael Prattes,Irina Grishkovskaya,Victor-Valentin Hodirnau et al.
Michael Prattes et al.
The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large ribosomal subunit. Drg1 releases the shuttling maturation factor Rlp24 from pre-60S particles shortly after nuclear exp...
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer [0.03%]
低聚糖负荷的mRNA转录本解析确定了肾癌中缺氧诱导因子和哺乳动物雷帕霉素靶点的失调交互作用
Yoichiro Sugimoto,Peter J Ratcliffe
Yoichiro Sugimoto
Hypoxia inducible factor (HIF) and mammalian target of rapamycin (mTOR) pathways orchestrate responses to oxygen and nutrient availability. These pathways are frequently dysregulated in cancer, but their interplay is poorly understood, in p...
Cohesin is required for long-range enhancer action at the Shh locus [0.03%]
凝缩素蛋白对于Shh基因座长程增强子作用是必需的
Lauren Kane,Iain Williamson,Ilya M Flyamer et al.
Lauren Kane et al.
The regulatory landscapes of developmental genes in mammals can be complex, with enhancers spread over many hundreds of kilobases. It has been suggested that three-dimensional genome organization, particularly topologically associating doma...
Cryo-EM structure of disease-related prion fibrils provides insights into seeding barriers [0.03%]
与疾病相关的朊病毒原纤维的冷冻电镜结构提供了关于播种障碍的见解
Qiuye Li,Christopher P Jaroniec,Witold K Surewicz
Qiuye Li
One of the least understood aspects of prion diseases is the structure of infectious prion protein aggregates. Here we report a high-resolution cryo-EM structure of amyloid fibrils formed by human prion protein with the Y145Stop mutation th...
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development [0.03%]
SARS-CoV-2 N7-甲基转移酶的高分辨率结构为药物研发提供信息
Jithesh Kottur,Olga Rechkoblit,Richard Quintana-Feliciano et al.
Jithesh Kottur et al.
Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (1.62 Å), S-adenosylhomocystein...