Jason Gorman,Chunyan Wang,Rosemarie D Mason et al.
Jason Gorman et al.
Simian immunodeficiency viruses (SIVs) are lentiviruses that naturally infect non-human primates of African origin and seeded cross-species transmissions of HIV-1 and HIV-2. Here we report prefusion stabilization and cryo-EM structures of s...
The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer [0.03%]
转录终止子XRN2和RNA结合蛋白Sam68将前列腺癌中的可变多聚腺苷酸化与细胞周期进展联系起来
Marco Pieraccioli,Cinzia Caggiano,Luca Mignini et al.
Marco Pieraccioli et al.
Alternative polyadenylation (APA) yields transcripts differing in their 3'-end, and its regulation is altered in cancer, including prostate cancer. Here we have uncovered a mechanism of APA regulation impinging on the interaction between th...
Switching under selection: how CoREST controls endocrine therapy resistance in ER+ breast cancer [0.03%]
在选择压力下的切换：CoREST如何控制ER阳性乳腺癌的内分泌治疗抗性
Brent Y Chick,Diana C Hargreaves
Brent Y Chick
Endocrine resistance and breast cancer plasticity are controlled by CoREST [0.03%]
CoREST控制内分泌抵抗和乳腺癌的可塑性
Liliana Garcia-Martinez,Andrew M Adams,Ho Lam Chan et al.
Liliana Garcia-Martinez et al.
Resistance to cancer treatment remains a major clinical hurdle. Here, we demonstrate that the CoREST complex is a key determinant of endocrine resistance and ER+ breast cancer plasticity. In endocrine-sensitive cells, CoREST is recruited to...
AAA+ protease-adaptor structures reveal altered conformations and ring specialization [0.03%]
AAA+蛋白酶-适配器结构揭示了构象的改变和环的特化
Sora Kim,Xue Fei,Robert T Sauer et al.
Sora Kim et al.
ClpAP, a two-ring AAA+ protease, degrades N-end-rule proteins bound by the ClpS adaptor. Here we present high-resolution cryo-EM structures of Escherichia coli ClpAPS complexes, showing how ClpA pore loops interact with the ClpS N-terminal ...
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing [0.03%]
干扰RNA剪接的近外显子内含子变异体的作用机制及建模研究人类疾病相关变异体
Hung-Lun Chiang,Yi-Ting Chen,Jia-Ying Su et al.
Hung-Lun Chiang et al.
It is estimated that 10%-30% of disease-associated genetic variants affect splicing. Splicing variants may generate deleteriously altered gene product and are potential therapeutic targets. However, systematic diagnosis or prediction of spl...
Author Correction: It's not just a phase: function and characteristics of RNA-binding proteins in phase separation [0.03%]
作者更正：RNA结合蛋白在相分离中的功能和特征并非只是一个阶段
Hannah J Wiedner,Jimena Giudice
Hannah J Wiedner
Published Erratum
Nature structural & molecular biology. 2022 Nov;29(11):1145. DOI:10.1038/s41594-022-00876-7 2022
Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker [0.03%]
帕金森病患者位点结构蛋白质组的全球原位分析以识别新型生物标志物亚群
Marie-Therese Mackmull,Luise Nagel,Fabian Sesterhenn et al.
Marie-Therese Mackmull et al.
Parkinson's disease (PD) is a prevalent neurodegenerative disease for which robust biomarkers are needed. Because protein structure reflects function, we tested whether global, in situ analysis of protein structural changes provides insight...
Distinct roles for CKM-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction [0.03%]
CKM-中介体在控制Polycomb依赖的染色体重塑和启动基因诱导中的不同作用
Emilia Dimitrova,Angelika Feldmann,Robin H van der Weide et al.
Emilia Dimitrova et al.
Precise control of gene expression underpins normal development. This relies on mechanisms that enable communication between gene promoters and other regulatory elements. In embryonic stem cells (ESCs), the cyclin-dependent kinase module Me...
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution [0.03%]
MiOS：一种整合影像与计算策略，以核小体分辨率建模基因折叠效应
Maria Victoria Neguembor,Juan Pablo Arcon,Diana Buitrago et al.
Maria Victoria Neguembor et al.
The linear sequence of DNA provides invaluable information about genes and their regulatory elements along chromosomes. However, to fully understand gene function and regulation, we need to dissect how genes physically fold in the three-dim...