Zachary Lee Johnson,Mark Ammirati,David Jonathan Wasilko et al.
Zachary Lee Johnson et al.
Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis. Hepatic expression of GPAT1 is linked to liver fat accumulation and the severity of n...
Sonja Rutz,Dawid Deneka,Antje Dittmann et al.
Sonja Rutz et al.
Volume-regulated anion channels (VRACs) participate in the cellular response to osmotic swelling. These membrane proteins consist of heteromeric assemblies of LRRC8 subunits, whose compositions determine permeation properties. Although stru...
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes [0.03%]
染色质重塑SWI / SNF复合物与先驱因子AP-1的配合塑造三维增强子景观
Bennett K Wolf,Yanding Zhao,Andrew McCray et al.
Bennett K Wolf et al.
The mechanism controlling the dynamic targeting of SWI/SNF has long been postulated to be coordinated by transcription factors (TFs), yet demonstrating a specific TF influence has proven difficult. Here we take a multi-omics approach to int...
Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules [0.03%]
帕金森氏症相关LRRK2结合微管的结构基础
David M Snead,Mariusz Matyszewski,Andrea M Dickey et al.
David M Snead et al.
Leucine-rich repeat kinase 2 (LRRK2) is one of the most commonly mutated genes in familial Parkinson's disease (PD). Under some circumstances, LRRK2 co-localizes with microtubules in cells, an association enhanced by PD mutations. We report...
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation [0.03%]
DNA甲基转移酶3A和3B在小鼠原肠形成过程中靶向特定序列
Zohar Mukamel,Aviezer Lifshitz,Markus Mittnenzweig et al.
Zohar Mukamel et al.
In mammalian embryos, DNA methylation is initialized to maximum levels in the epiblast by the de novo DNA methyltransferases DNMT3A and DNMT3B before gastrulation diversifies it across regulatory regions. Here we show that DNMT3A and DNMT3B...
Judith Barbara Zaugg,Pelin Sahlén,Robin Andersson et al.
Judith Barbara Zaugg et al.
Enhancers play a central role in the spatiotemporal control of gene expression and tend to work in a cell-type-specific manner. In addition, they are suggested to be major contributors to phenotypic variation, evolution and disease. There i...
Anne-Laure Valton,Sergey V Venev,Barbara Mair et al.
Anne-Laure Valton et al.
Cohesin-mediated loop extrusion has been shown to be blocked at specific cis-elements, including CTCF sites, producing patterns of loops and domain boundaries along chromosomes. Here we explore such cis-elements, and their role in gene regu...
A critical period of translational control during brain development at codon resolution [0.03%]
大脑发育过程中在密码子水平上进行翻译调控的关键时期
Dermot Harnett,Mateusz C Ambrozkiewicz,Ulrike Zinnall et al.
Dermot Harnett et al.
Translation modulates the timing and amplification of gene expression after transcription. Brain development requires uniquely complex gene expression patterns, but large-scale measurements of translation directly in the prenatal brain are ...
Katharine H Wrighton
Katharine H Wrighton
Tim Thomas
Tim Thomas