EGOC inhibits TOROID polymerization by structurally activating TORC1 [0.03%]
EGOC通过结构活化TORC1抑制TOROID聚合
Manoël Prouteau,Clélia Bourgoint,Jan Felix et al.
Manoël Prouteau et al.
Target of rapamycin complex 1 (TORC1) is a protein kinase controlling cell homeostasis and growth in response to nutrients and stresses. In Saccharomyces cerevisiae, glucose depletion triggers a redistribution of TORC1 from a dispersed loca...
Author Correction: Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5 [0.03%]
作者更正：通过未结合配体的NAIP5的低温电镜结构揭示NAIP-NLRC4炎性小体激活机制
Bhaskar Paidimuddala,Jianhao Cao,Grady Nash et al.
Bhaskar Paidimuddala et al.
Published Erratum
Nature structural & molecular biology. 2023 Feb;30(2):233. DOI:10.1038/s41594-023-00927-7 2023
Author Correction: A multipoint guidance mechanism for β-barrel folding on the SAM complex [0.03%]
作者更正：SAM 复合物上β- barrels 投稿的多点指导机制
Hironori Takeda,Jon V Busto,Caroline Lindau et al.
Hironori Takeda et al.
Published Erratum
Nature structural & molecular biology. 2023 Feb;30(2):233. DOI:10.1038/s41594-023-00926-8 2023
David F Burke,Patrick Bryant,Inigo Barrio-Hernandez et al.
David F Burke et al.
Cellular functions are governed by molecular machines that assemble through protein-protein interactions. Their atomic details are critical to studying their molecular mechanisms. However, fewer than 5% of hundreds of thousands of human pro...
Two rings to fold them [0.03%]
两个环来折叠它们
Katarzyna Ciazynska
Katarzyna Ciazynska
Dimitris Typas
Dimitris Typas
Sara Osman
Sara Osman
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition [0.03%]
通过多聚（A）尾部对母系mRNA的改造调控人类卵母细胞向胚胎的转变
Yusheng Liu,Han Zhao,Fanghong Shao et al.
Yusheng Liu et al.
Poly(A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in the oocyte-to-embryo transition (OET). Nothing is known about poly(A) tail dynamics during the human OET. Here, we show that poly(A) tail length and interna...
Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3 [0.03%]
由SYCE3调控的SYCP1介导的减数分裂染色体联会的结构成熟过程
James H Crichton,James M Dunce,Orla M Dunne et al.
James H Crichton et al.
In meiosis, a supramolecular protein structure, the synaptonemal complex (SC), assembles between homologous chromosomes to facilitate their recombination. Mammalian SC formation is thought to involve hierarchical zipper-like assembly of an ...
Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis [0.03%]
钙调蛋白激活志贺氏菌效应因子OspC3的结构机制，ADP核糖化caspase-4/11并阻断焦亡过程
Yanjie Hou,Huan Zeng,Zilin Li et al.
Yanjie Hou et al.
The caspase-4/11-GSDMD pyroptosis axis recognizes cytosolic lipopolysaccharide for antibacterial defenses. Shigella flexneri employs an OspC3 effector to block pyroptosis by catalyzing NAD+-dependent arginine ADP-riboxanation of caspase-4/1...