Sara Osman
Sara Osman
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13 [0.03%]
必要内源性分支杆菌聚酮合成酶Pks13的结构与动态变化机制
Sun Kyung Kim,Miles Sasha Dickinson,Janet Finer-Moore et al.
Sun Kyung Kim et al.
The mycolic acid layer of the Mycobacterium tuberculosis cell wall is essential for viability and virulence, and the enzymes responsible for its synthesis are targets for antimycobacterial drug development. Polyketide synthase 13 (Pks13) is...
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas [0.03%]
胞内菌胆固醇和其他重要脂质的供应者P116蛋白
Lasse Sprankel,David Vizarraga,Jesús Martín et al.
Lasse Sprankel et al.
Mycoplasma pneumoniae, responsible for approximately 30% of community-acquired human pneumonia, needs to extract lipids from the host environment for survival and proliferation. Here, we report a comprehensive structural and functional anal...
Dimitris Typas
Dimitris Typas
A molecular switch modulates assembly and host factor binding of the HIV-1 capsid [0.03%]
一个分子开关可调节HIV-1衣壳的装配和宿主因子结合
Randall T Schirra,Nayara F B Dos Santos,Kaneil K Zadrozny et al.
Randall T Schirra et al.
The HIV-1 capsid is a fullerene cone made of quasi-equivalent hexamers and pentamers of the viral CA protein. Typically, quasi-equivalent assembly of viral capsid subunits is controlled by a molecular switch. Here, we identify a Thr-Val-Gly...
Kelli L Hvorecny,Kenzee Hargett,Joel D Quispe et al.
Kelli L Hvorecny et al.
The universally conserved enzyme phosphoribosyl pyrophosphate synthetase (PRPS) assembles filaments in evolutionarily diverse organisms. PRPS is a key regulator of nucleotide metabolism, and mutations in the human enzyme PRPS1 lead to a spe...
Signal-induced enhancer activation requires Ku70 to read topoisomerase1-DNA covalent complexes [0.03%]
信号诱导的增强子激活需要Ku70来识别拓扑异构酶1-DNA共价复合物
Yuliang Tan,Lu Yao,Amir Gamliel et al.
Yuliang Tan et al.
Enhancer activation serves as the main mechanism regulating signal-dependent transcriptional programs, ensuring cellular plasticity, yet central questions persist regarding their mechanism of activation. Here, by successfully mapping topois...
Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication [0.03%]
四聚体糖皮质激素受体结构揭示别构跨域通讯
Sandra Postel,Lisa Wissler,Carina A Johansson et al.
Sandra Postel et al.
The glucocorticoid receptor (GR) is a ligand-activated transcription factor that binds DNA and assembles co-regulator complexes to regulate gene transcription. GR agonists are widely prescribed to people with inflammatory and autoimmune dis...
Patrick Schultz
Patrick Schultz
CRISPR-Cas has a new juggling act: interplay between nuclease and protease [0.03%]
CRISPR-Cas有了新玩法：核酸酶与蛋白酶的相互作用
Anthony D Rish,Tian-Min Fu
Anthony D Rish