Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids [0.03%]
直接可视化转录-复制冲突可揭示后复制品DNA：RNA杂交体
Henriette Stoy,Katharina Zwicky,Danina Kuster et al.
Henriette Stoy et al.
Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-loops were linked to head-on TRCs and proposed to obstruct replication fork progression. The underlying mechanisms, however, remained elusive due ...
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity [0.03%]
外显子1的病原性亨廷顿蛋白结构定义了其聚集趋势的基础
Carlos A Elena-Real,Amin Sagar,Annika Urbanek et al.
Carlos A Elena-Real et al.
Huntington's disease is a neurodegenerative disorder caused by a CAG expansion in the first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin (httex1). The structural changes occurring to the poly-Q w...
Chunxiang Wu,Yong Xiong
Chunxiang Wu
Recent studies offer new insight on the mechanisms of IP6-mediated HIV-1 capsid assembly. The immature Gag lattice enables enrichment of IP6 into virions, aiding capsid maturation. Structures of capsid protein (CA) assemblies reveal motifs ...
Short poly(A) tails are protected from deadenylation by the LARP1-PABP complex [0.03%]
短聚腺苷酸尾丝通过LARP1-PABP复合物免受去多腺苷酸化保护
Joha Park,Myeonghwan Kim,Hyerim Yi et al.
Joha Park et al.
Deadenylation generally constitutes the first and pivotal step in eukaryotic messenger RNA decay. Despite its importance in posttranscriptional regulations, the kinetics of deadenylation and its regulation remain largely unexplored. Here we...
Author Correction: Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging [0.03%]
作者更正：HIV-1 5' UTR 中的短程和长程相互作用调节基因组二聚化和包装
Liqing Ye,Anne-Sophie Gribling-Burrer,Patrick Bohn et al.
Liqing Ye et al.
Published Erratum
Nature structural & molecular biology. 2023 Mar;30(3):403. DOI:10.1038/s41594-023-00946-4 2023
Katarina Meze,Armend Axhemi,Dennis R Thomas et al.
Katarina Meze et al.
RNA turnover pathways ensure appropriate gene expression levels by eliminating unwanted transcripts. Dis3-like 2 (Dis3L2) is a 3'-5' exoribonuclease that plays a critical role in human development. Dis3L2 independently degrades structured s...
Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels [0.03%]
具有核孔复合体 gated DNA-Origami 通道的 HIV-1 核输入建模
Qi Shen,Qingzhou Feng,Chunxiang Wu et al.
Qi Shen et al.
Delivering the virus genome into the host nucleus through the nuclear pore complex (NPC) is pivotal in human immunodeficiency virus 1 (HIV-1) infection. The mechanism of this process remains mysterious owing to the NPC complexity and the la...
Nazim Bouatta,Mohammed AlQuraishi
Nazim Bouatta
AlphaFold2 has already changed structural biology but its true power may lie in how it changes the way we think about cells and organisms. Two studies broadly analyze and assess the performance of AlphaFold2 to outline the extent of its uti...
The activated inflammasome [0.03%]
活化的炎性小体
Katarzyna Ciazynska
Katarzyna Ciazynska