Katarzyna Ciazynska
Katarzyna Ciazynska
Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels [0.03%]
LRRC8A:C容积调节阴离子通道的组装和脂质门控结构基础
David M Kern,Julia Bleier,Somnath Mukherjee et al.
David M Kern et al.
Leucine-rich repeat-containing protein 8 (LRRC8) family members form volume-regulated anion channels activated by hypoosmotic cell swelling. LRRC8 channels are ubiquitously expressed in vertebrate cells as heteromeric assemblies of LRRC8A (...
Pierre Barraud,Carine Tisné
Pierre Barraud
Heterochromatin rewiring and domain disruption-mediated chromatin compaction during erythropoiesis [0.03%]
红细胞生成过程中异染色质重构和功能域解体介导的染色质凝聚
Dong Li,Fan Wu,Shuo Zhou et al.
Dong Li et al.
Mammalian erythropoiesis involves progressive chromatin compaction and subsequent enucleation in terminal differentiation, but the mechanisms underlying the three-dimensional chromatin reorganization remain obscure. Here, we systematically ...
R J McGinty,S R Sunyaev
R J McGinty
Non-B DNA structures formed by repetitive sequence motifs are known instigators of mutagenesis in experimental systems. Analyzing this phenomenon computationally in the human genome requires careful disentangling of intrinsic confounding fa...
Long Han,Qinhui Rao,Renbin Yang et al.
Long Han et al.
Published Erratum
Nature structural & molecular biology. 2023 Apr;30(4):564. DOI:10.1038/s41594-023-00961-5 2023
cGAMP-activated cGAS-STING signaling: its bacterial origins and evolutionary adaptation by metazoans [0.03%]
由细菌起源并通过真核生物进化的cGAMP激活的cGAS-STING信号通路
Dinshaw J Patel,You Yu,Wei Xie
Dinshaw J Patel
The metazoan cGAMP-activated cGAS-STING innate immunity pathway is triggered in response to genomic instability and DNA damage, thereby providing host defense against microbial pathogens. This pathway also impacts on autophagy, cellular sen...
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres [0.03%]
RPA相分离的高亲和力单链DNA结合及端粒处动态凝聚功能属性
Vincent Spegg,Andreas Panagopoulos,Merula Stout et al.
Vincent Spegg et al.
RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is required for downstream ssDNA transactions. How ultrahigh-affinity b...
ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells [0.03%]
自动取款机信号调节了减数分裂偶线期和增殖细胞中cohesin的行为方式
Zhouliang Yu,Hyung Jun Kim,Abby F Dernburg
Zhouliang Yu
Cohesins are ancient and ubiquitous regulators of chromosome architecture and function, but their diverse roles and regulation remain poorly understood. During meiosis, chromosomes are reorganized as linear arrays of chromatin loops around ...
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence [0.03%]
作者更正：O-连接的糖基转移酶活性部位对其底物序列有一定的约束作用
Shalini Pathak,Jana Alonso,Marianne Schimpl et al.
Shalini Pathak et al.
Published Erratum
Nature structural & molecular biology. 2023 Apr;30(4):564. DOI:10.1038/s41594-023-00945-5 2023