Control of transcription elongation and DNA repair by alarmone ppGpp [0.03%]
警报物ppGpp对转录延长及DNA修复的调控作用
Jacob W Weaver,Sergey Proshkin,Wenqian Duan et al.
Jacob W Weaver et al.
Second messenger (p)ppGpp (collectively guanosine tetraphosphate and guanosine pentaphosphate) mediates bacterial adaptation to nutritional stress by modulating transcription initiation. More recently, ppGpp has been implicated in coupling ...
Mapping the conformational landscape of the stimulatory heterotrimeric G protein [0.03%]
刺激性异三聚体G蛋白构象景观映射
Shuya Kate Huang,Louis-Philippe Picard,Rima S M Rahmatullah et al.
Shuya Kate Huang et al.
Heterotrimeric G proteins serve as membrane-associated signaling hubs, in concert with their cognate G-protein-coupled receptors. Fluorine nuclear magnetic resonance spectroscopy was employed to monitor the conformational equilibria of the ...
Zhou Chen,Abhisek Mondal,Daniel L Minor Jr
Zhou Chen
Gabapentinoid drugs for pain and anxiety act on the CaVα2δ-1 and CaVα2δ-2 subunits of high-voltage-activated calcium channels (CaV1s and CaV2s). Here we present the cryo-EM structure of the gabapentin-bound brain and cardiac CaV1.2/CaV...
Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel [0.03%]
环核苷酸门控离子通道中环核苷酸的区分作用
Yangang Pan,Emmi Pohjolainen,Philipp A M Schmidpeter et al.
Yangang Pan et al.
Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the heart. SthK is a prokaryotic homolog with high sequence and structure similarities to hyperpolarization-activated and cycl...
Alexandra Tsirigotaki,Ann Dansercoer,Koen H G Verschueren et al.
Alexandra Tsirigotaki et al.
The adipokine Leptin activates its receptor LEP-R in the hypothalamus to regulate body weight and exerts additional pleiotropic functions in immunity, fertility and cancer. However, the structure and mechanism of Leptin-mediated LEP-R assem...
The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities [0.03%]
DREAM复合体作为保守的体细胞DNA修复能力主调节因子的功能
Arturo Bujarrabal-Dueso,Georg Sendtner,David H Meyer et al.
Arturo Bujarrabal-Dueso et al.
The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has remained unknown whether not only lesion-type-specific, but overall repair capacities could be improved. Here we show that the DREAM repressor comp...
Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits [0.03%]
具有GluN2C和GluN2D亚基的多样化NMDA受体的不同结构和门控机制
Jilin Zhang,Ming Zhang,Qinrui Wang et al.
Jilin Zhang et al.
N-methyl-D-aspartate (NMDA) receptors are heterotetramers comprising two GluN1 and two alternate GluN2 (N2A-N2D) subunits. Here we report full-length cryo-EM structures of the human N1-N2D di-heterotetramer (di-receptor), rat N1-N2C di-rece...
Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis [0.03%]
H3K9三甲基化丧失可改变有丝分裂中的染色体凝集和转录因子滞留
Dounia Djeghloul,Andrew Dimond,Sherry Cheriyamkunnel et al.
Dounia Djeghloul et al.
Recent studies have shown that repressive chromatin machinery, including DNA methyltransferases and polycomb repressor complexes, binds to chromosomes throughout mitosis and their depletion results in increased chromosome size. In the prese...
Dimitris Typas
Dimitris Typas
Sara Osman
Sara Osman