Dimitris Typas
Dimitris Typas
A co-transcriptional ribosome assembly checkpoint controls nascent large ribosomal subunit maturation [0.03%]
一种协同转录的核糖体装配检查点控制新生的大核糖体亚基成熟
Zahra A Sanghai,Rafal Piwowarczyk,Arnaud Vanden Broeck et al.
Zahra A Sanghai et al.
During transcription of eukaryotic ribosomal DNA in the nucleolus, assembly checkpoints exist that guarantee the formation of stable precursors of small and large ribosomal subunits. While the formation of an early large subunit assembly ch...
Author Correction: Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2 [0.03%]
作者更正：哺乳动物Na+/H+交换器NHA2的结构、机制和脂质介导的重塑
Rei Matsuoka,Roman Fudim,Sukkyeong Jung et al.
Rei Matsuoka et al.
Published Erratum
Nature structural & molecular biology. 2023 Apr;30(4):565. DOI:10.1038/s41594-023-00970-4 2023
Mistimed origin licensing and activation stabilize common fragile sites under tight DNA-replication checkpoint activation [0.03%]
错配的许可和激活稳定共同脆弱位点在严格的DNA复制检查点活化下
Olivier Brison,Stefano Gnan,Dana Azar et al.
Olivier Brison et al.
Genome integrity requires replication to be completed before chromosome segregation. The DNA-replication checkpoint (DRC) contributes to this coordination by inhibiting CDK1, which delays mitotic onset. Under-replication of common fragile s...
Michael Taschner,Stephan Gruber
Michael Taschner
Three distinct structural maintenance of chromosomes (SMC) complexes facilitate chromosome folding and segregation in eukaryotes, presumably by DNA loop extrusion. How SMCs interact with DNA to extrude loops is not well understood. Among th...
Regulation of human trophoblast gene expression by endogenous retroviruses [0.03%]
人类内源性逆转录病毒对滋养外胚层基因表达的调控作用
Jennifer M Frost,Samuele M Amante,Hiroaki Okae et al.
Jennifer M Frost et al.
The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their capacity...
Structure of AlkB-AlkG shows details of alkane terminal C-H selectivity and functionalization [0.03%]
AlkB-AlkG结构展示烷烃末端C-H选择性和官能化的细节
The cryo-EM structure of a natural AlkB–AlkG fusion from Fontimonas thermophila reveals the mechanistic basis for its selectivity towards, and functionalization of, alkane terminal C–H groups. AlkB contains an alkane entry tunnel and a di...
Structural basis for enzymatic terminal C-H bond functionalization of alkanes [0.03%]
酶催化烷烃末端C-H键活化的结构基础
Jin Chai,Gongrui Guo,Sean M McSweeney et al.
Jin Chai et al.
Alkane monooxygenase (AlkB) is a widely occurring integral membrane metalloenzyme that catalyzes the initial step in the functionalization of recalcitrant alkanes with high terminal selectivity. AlkB enables diverse microorganisms to use al...