The RNA m6A landscape of mouse oocytes and preimplantation embryos [0.03%]
小鼠卵母细胞和着床前胚胎的RNA N6-甲基腺苷图谱
Yunhao Wang,Yanjiao Li,Trine Skuland et al.
Yunhao Wang et al.
Despite the significance of N6-methyladenosine (m6A) in gene regulation, the requirement for large amounts of RNA has hindered m6A profiling in mammalian early embryos. Here we apply low-input methyl RNA immunoprecipitation and sequencing t...
Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site [0.03%]
纤维微原纤维结构揭示了影响关键调控的潜在TGFβ结合位点的遗传病理性突变的远距离效应
Alan R F Godwin,Rana Dajani,Xinyang Zhang et al.
Alan R F Godwin et al.
Genetic mutations in fibrillin microfibrils cause serious inherited diseases, such as Marfan syndrome and Weill-Marchesani syndrome (WMS). These diseases typically show major dysregulation of tissue development and growth, particularly in s...
Mechanism of RecF-RecO-RecR cooperation in bacterial homologous recombination [0.03%]
细菌同源重组中RecF-RecO-RecR协同作用的机制
Shivlee Nirwal,Mariusz Czarnocki-Cieciura,Anuradha Chaudhary et al.
Shivlee Nirwal et al.
In bacteria, one type of homologous-recombination-based DNA-repair pathway involves RecFOR proteins that bind at the junction between single-stranded (ss) and double-stranded (ds) DNA. They facilitate the replacement of SSB protein, which i...
Katarzyna Ciazynska
Katarzyna Ciazynska
How to control hunger [0.03%]
如何控制饥饿感
Albert Hung,Eunhee Choi
Albert Hung
Qixiang He,Andrey G Baranovskiy,Lucia M Morstadt et al.
Qixiang He et al.
The synthesis of RNA-DNA primer by primosome requires coordination between primase and DNA polymerase α subunits, which is accompanied by unknown architectural rearrangements of multiple domains. Using cryogenic electron microscopy, we sol...
Author Correction: Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization [0.03%]
作者更正：DNA损伤后的基因组多尺度重组通过核内肌动蛋白聚合促进染色体易位
Jennifer Zagelbaum,Allana Schooley,Junfei Zhao et al.
Jennifer Zagelbaum et al.
Published Erratum
Nature structural & molecular biology. 2023 Jul;30(7):1048. DOI:10.1038/s41594-023-00994-w 2023
Gurushankar Chandramouly,Joonas Jamsen,Nikita Borisonnik et al.
Gurushankar Chandramouly et al.
Published Erratum
Nature structural & molecular biology. 2023 Jul;30(7):1048. DOI:10.1038/s41594-023-00993-x 2023
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor [0.03%]
胰岛素受体相关受体激活的结构基础：依赖碱性PH值的作用机制
Liwei Wang,Catherine Hall,Jie Li et al.
Liwei Wang et al.
The insulin receptor (IR) family is a subfamily of receptor tyrosine kinases that controls metabolic homeostasis and cell growth. Distinct from IR and insulin-like growth factor 1 receptor, whose activation requires ligand binding, insulin ...
Dimitris Typas
Dimitris Typas