Anita K Hopper,Jinwei Zhang
Anita K Hopper
Kendra Reynaud,Anna M McGeachy,David Noble et al.
Kendra Reynaud et al.
Numerous proteins regulate gene expression by modulating mRNA translation and decay. To uncover the full scope of these post-transcriptional regulators, we conducted an unbiased survey that quantifies regulatory activity across the budding ...
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex [0.03%]
人tRNA剪接内切酶复合物识别和加工前tRNA的结构基础
Cassandra K Hayne,Kevin John U Butay,Zachary D Stewart et al.
Cassandra K Hayne et al.
Throughout bacteria, archaea and eukarya, certain tRNA transcripts contain introns. Pre-tRNAs with introns require splicing to form the mature anticodon stem loop. In eukaryotes, tRNA splicing is initiated by the heterotetrameric tRNA splic...
Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN [0.03%]
人类tRNA剪接内切酶TSEN底物识别的结构基础
Samoil Sekulovski,Lukas Sušac,Lukas S Stelzl et al.
Samoil Sekulovski et al.
Heterotetrameric human transfer RNA (tRNA) splicing endonuclease TSEN catalyzes intron excision from precursor tRNAs (pre-tRNAs), utilizing two composite active sites. Mutations in TSEN and its associated RNA kinase CLP1 are linked to the n...
Phosphatidylserine-dependent structure of synaptogyrin remodels the synaptic vesicle membrane [0.03%]
磷脂酰丝氨酸依赖性的突触gyrin结构重塑突触小泡膜
Taekyung Yu,David Flores-Solis,Gunnar N Eastep et al.
Taekyung Yu et al.
Synaptic vesicles are small membrane-enclosed organelles that store neurotransmitters at presynaptic terminals. The uniform morphology of synaptic vesicles is important for brain function, because it enables the storage of well-defined amou...
Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity [0.03%]
Polycomb蛋白内在的介观特性决定了异染色质的保真度
Sujin Lee,Stephen Abini-Agbomson,Daniela S Perry et al.
Sujin Lee et al.
Little is understood about how the two major types of heterochromatin domains (HP1 and Polycomb) are kept separate. In the yeast Cryptococcus neoformans, the Polycomb-like protein Ccc1 prevents deposition of H3K27me3 at HP1 domains. Here we...
Polγ coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity [0.03%]
Polγ通过协调DNA合成和校对确保线粒体基因组的完整性
Joon Park,Geoffrey K Herrmann,Patrick G Mitchell et al.
Joon Park et al.
Accurate replication of mitochondrial DNA (mtDNA) by DNA polymerase γ (Polγ) is essential for maintaining cellular energy supplies, metabolism, and cell cycle control. To illustrate the structural mechanism for Polγ coordinating polymera...
RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals [0.03%]
通过m6A甲基化调控的RNA稳定性参与哺乳动物X染色体失活补偿机制
Cornelia Rücklé,Nadine Körtel,M Felicia Basilicata et al.
Cornelia Rücklé et al.
In mammals, X-chromosomal genes are expressed from a single copy since males (XY) possess a single X chromosome, while females (XX) undergo X inactivation. To compensate for this reduction in dosage compared with two active copies of autoso...
Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment [0.03%]
核仁装配缺陷通过NPM1介导的PRC2募集导致二细胞转录抑制
Dingfeng Li,Ran Cao,Qiaodan Li et al.
Dingfeng Li et al.
The nucleolus is a compartmentalized organelle in eukaryotic cells known to form during embryogenesis, yet how its layered architecture is transformed from homogenous precursor bodies is unclear, and any impacts of this formation on embryon...