Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism [0.03%]
GABA转运蛋白1的冷冻电镜结构揭示了底物识别和运输机制
Smruti Ranjan Nayak,Deepthi Joseph,Georg Höfner et al.
Smruti Ranjan Nayak et al.
The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is cleared from the synaptic cleft by the sodium- and chloride-coupled GABA transporter GAT1. Inhibition of GAT1 prolongs the GABAergic signaling at the synapse and is a strategy t...
Shintaro Minami,Naohiro Kobayashi,Toshihiko Sugiki et al.
Shintaro Minami et al.
A fundamental question in protein evolution is whether nature has exhaustively sampled nearly all possible protein folds throughout evolution, or whether a large fraction of the possible folds remains unexplored. To address this question, w...
Orchestrating nucleic acid-protein interactions at chromosome ends: telomerase mechanisms come into focus [0.03%]
染色体末端的核酸-蛋白质相互作用：端粒酶机制逐渐清晰
Neal F Lue,Chantal Autexier
Neal F Lue
Telomerase is a special reverse transcriptase ribonucleoprotein dedicated to the synthesis of telomere repeats that protect chromosome ends. Among reverse transcriptases, telomerase is unique in using a stably associated RNA with an embedde...
Publisher Correction: Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site [0.03%]
出版更正：纤连蛋白微原纤维结构识别影响关键调节潜伏TGFβ结合位点的遗传致病突变的远距离效应
Alan R F Godwin,Rana Dajani,Xinyang Zhang et al.
Alan R F Godwin et al.
Published Erratum
Nature structural & molecular biology. 2023 Oct;30(10):1608. DOI:10.1038/s41594-023-01050-3 2023
Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID [0.03%]
hierarchical TAF1依赖的转录因子TFIID共翻译装配过程
Andrea Bernardini,Pooja Mukherjee,Elisabeth Scheer et al.
Andrea Bernardini et al.
Large heteromeric multiprotein complexes play pivotal roles at every step of gene expression in eukaryotic cells. Among them, the 20-subunit basal transcription factor TFIID nucleates the RNA polymerase II preinitiation complex at gene prom...
Readout of histone methylation by Trim24 locally restricts chromatin opening by p53 [0.03%]
TriM24通过局部限制p53介导的染色质开放作用而读取组蛋白甲基化状态
Luke Isbel,Murat Iskar,Sevi Durdu et al.
Luke Isbel et al.
The genomic binding sites of the transcription factor (TF) and tumor suppressor p53 are unusually diverse with regard to their chromatin features, including histone modifications, raising the possibility that the local chromatin environment...
Kirill Kovalev,Fedor Tsybrov,Alexey Alekseev et al.
Kirill Kovalev et al.
Proton transport is indispensable for cell life. It is believed that molecular mechanisms of proton movement through different types of proton-conducting molecules have general universal features. However, elucidation of such mechanisms is ...
The multi-functional Smc5/6 complex in genome protection and disease [0.03%]
功能多样的Smc5/6复合体在基因组保护及疾病中的作用
Xiao P Peng,Xiaolan Zhao
Xiao P Peng
Structural maintenance of chromosomes (SMC) complexes are ubiquitous genome regulators with a wide range of functions. Among the three types of SMC complexes in eukaryotes, cohesin and condensin fold the genome into different domains and st...
Adriana Savastano
Adriana Savastano