Pre-mRNA splicing order is predetermined and maintains splicing fidelity across multi-intronic transcripts [0.03%]
.pre-mRNA剪接顺序预先确定并能够维持多内含子前体信使rna的剪接保真度
Karine Choquet,Autum R Baxter-Koenigs,Sarah-Luisa Dülk et al.
Karine Choquet et al.
Combinatorially, intron excision within a given nascent transcript could proceed down any of thousands of paths, each of which would expose different dynamic landscapes of cis-elements and contribute to alternative splicing. In this study, ...
Brian J Sutton
Brian J Sutton
Shyam Ramasamy,Abrar Aljahani,Magdalena A Karpinska et al.
Shyam Ramasamy et al.
Enhancer-mediated gene activation generally requires physical proximity between enhancers and their target gene promoters. However, the molecular mechanisms by which interactions between enhancers and promoters are formed are not well under...
Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein [0.03%]
SARS-CoV-2奥密克戎亚变体BA.2刺突蛋白的结构和功能特征
Jun Zhang,Weichun Tang,Hailong Gao et al.
Jun Zhang et al.
The Omicron subvariant BA.2 has become the dominant circulating strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in many countries. Here, we have characterized structural, functional and antigenic properties of the ful...
Author Correction: RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals [0.03%]
作者更正：m6A甲基化控制的RNA稳定性有助于哺乳动物X染色体归一化剂量补偿现象
Cornelia Rücklé,Nadine Körtel,M Felicia Basilicata et al.
Cornelia Rücklé et al.
Published Erratum
Nature structural & molecular biology. 2023 Oct;30(10):1607. DOI:10.1038/s41594-023-01053-0 2023
Jenna M Whalen,Sharon B Cantor
Jenna M Whalen
The energy landscape for R-loop formation by the CRISPR-Cas Cascade complex [0.03%]
由CRISPR-Cas Cascade复合物形成的R环的能景图式
Dominik J Kauert,Julene Madariaga-Marcos,Marius Rutkauskas et al.
Dominik J Kauert et al.
Clustered regularly interspaced short palindromic repeats (CRISPR) sequences and CRISPR-associated (Cas) genes comprise CIRSPR-Cas effector complexes, which have revolutionized gene editing with their ability to target specific genomic loci...
Azadeh Shahsavar,Petrine Wellendorph
Azadeh Shahsavar
Molecular basis for substrate recognition and transport of human GABA transporter GAT1 [0.03%]
人类GABA转运蛋白GAT1的底物识别和转运的分子机制
Angqi Zhu,Junhao Huang,Fang Kong et al.
Angqi Zhu et al.
γ-Aminobutyric acid (GABA), an important inhibitory neurotransmitter in the central nervous system, is recycled through specific GABA transporters (GATs). GAT1, which is mainly expressed in the presynaptic terminals of axons, is a potentia...