Ricardo Mack,Or Gozani
Ricardo Mack
The development of an epigenetics-focused, CRISPR-based high-content functional genomics screening platform provides insight into chromatin regulation and uncovers a potential strategy to treat an aggressive type of leukemia.
Publisher Correction: In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search [0.03%]
出版更正：体内跟踪功能标记Rad51揭示了同源搜索的稳健策略
Siyu Liu,Judith Miné-Hattab,Marie Villemeur et al.
Siyu Liu et al.
Published Erratum
Nature structural & molecular biology. 2023 Oct;30(10):1607. DOI:10.1038/s41594-023-01114-4 2023
CRISPR-ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia [0.03%]
利用CRISPR-ChIP揭示Menin在MLL白血病中选择性调节H3K79me2的作用
Omer Gilan,Laure Talarmain,Charles C Bell et al.
Omer Gilan et al.
Chromatin regulation involves the selective recruitment of chromatin factors to facilitate DNA repair, replication and transcription. Here we demonstrate the utility of coupling unbiased functional genomics with chromatin immunoprecipitatio...
Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth [0.03%]
细胞大小调控确保细胞生长过程中的线粒体DNA稳态
Anika Seel,Francesco Padovani,Moritz Mayer et al.
Anika Seel et al.
To maintain stable DNA concentrations, proliferating cells need to coordinate DNA replication with cell growth. For nuclear DNA, eukaryotic cells achieve this by coupling DNA replication to cell-cycle progression, ensuring that DNA is doubl...
Michael J Capper,Shifan Yang,Alexander C Stone et al.
Michael J Capper et al.
Anion exchanger 1 (AE1), a member of the solute carrier (SLC) family, is the primary bicarbonate transporter in erythrocytes, regulating pH levels and CO2 transport between lungs and tissues. Previous studies characterized its role in eryth...
Eray Enustun,Amar Deep,Yajie Gu et al.
Eray Enustun et al.
In the arms race between bacteria and bacteriophages (phages), some large-genome jumbo phages have evolved a protein shell that encloses their replicating genome to protect it against host immune factors. By segregating the genome from the ...
KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion [0.03%]
KsgA通过校读关键结构病变来促进核糖体小亚基成熟
Jingyu Sun,Laurel F Kinman,Dushyant Jahagirdar et al.
Jingyu Sun et al.
Ribosome assembly is orchestrated by many assembly factors, including ribosomal RNA methyltransferases, whose precise role is poorly understood. Here, we leverage the power of cryo-EM and machine learning to discover that the E. coli methyl...
Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4-NOT [0.03%]
哺乳动物CCR4-NOT特异性识别并泛素化翻译中的核糖体
Eva Absmeier,Viswanathan Chandrasekaran,Francis J O&#x;Reilly et al.
Eva Absmeier et al.
Translation affects messenger RNA stability and, in yeast, this is mediated by the Ccr4-Not deadenylation complex. The details of this process in mammals remain unclear. Here, we use cryogenic electron microscopy (cryo-EM) and crosslinking ...
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis [0.03%]
前蛋白酶体的结构揭示了核心颗粒生物发生后期阶段的状态
Richard M Walsh Jr,Shaun Rawson,Helena M Schnell et al.
Richard M Walsh Jr et al.
Assembly of the proteasome's core particle (CP), a barrel-shaped chamber of four stacked rings, requires five chaperones and five subunit propeptides. Fusion of two half-CP precursors yields a complete structure but remains immature until a...