m6A governs length-dependent enrichment of mRNAs in stress granules [0.03%]
m6A调节mRNA在应激颗粒中的长度依赖性富集现象
Ryan J Ries,Brian F Pickering,Hui Xian Poh et al.
Ryan J Ries et al.
Stress granules are biomolecular condensates composed of protein and mRNA. One feature of stress granule-enriched mRNAs is that they are often longer than average. Another feature of stress granule-enriched mRNAs is that they often contain ...
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase [0.03%]
霍乱弧菌NADH:醌氧化还原酶中与钠+位移的氧化还原驱动耦合的构象变化
Jann-Louis Hau,Susann Kaltwasser,Valentin Muras et al.
Jann-Louis Hau et al.
In the respiratory chain, NADH oxidation is coupled to ion translocation across the membrane to build up an electrochemical gradient. In the human pathogen Vibrio cholerae, the sodium-pumping NADH:quinone oxidoreductase (Na+-NQR) generates ...
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays [0.03%]
结构揭示基因组折叠为何需要特异性整合外源DNA进入CRISPR数组中
Andrew Santiago-Frangos,William S Henriques,Tanner Wiegand et al.
Andrew Santiago-Frangos et al.
Bacteria and archaea acquire resistance to viruses and plasmids by integrating fragments of foreign DNA into the first repeat of a CRISPR array. However, the mechanism of site-specific integration remains poorly understood. Here, we determi...
Clinton K Lau
Clinton K Lau
Dimitris Typas
Dimitris Typas
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells [0.03%]
S期启动时的转录抑制可保护多能细胞的基因组完整性
Deniz Gökbuget,Kayla Lenshoek,Ryan M Boileau et al.
Deniz Gökbuget et al.
Coincident transcription and DNA replication causes replication stress and genome instability. Rapidly dividing mouse pluripotent stem cells are highly transcriptionally active and experience elevated replication stress, yet paradoxically m...
Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs [0.03%]
DYNLL1-MRE11复合体的动力学调控DNA末端重切及Shieldin招募至DSB
Michelle L Swift,Rui Zhou,Aleem Syed et al.
Michelle L Swift et al.
The extent and efficacy of DNA end resection at DNA double-strand breaks (DSB) determine the repair pathway choice. Here we describe how the 53BP1-associated protein DYNLL1 works in tandem with the Shieldin complex to protect DNA ends. DYNL...
Molecular pathway of mitochondrial preprotein import through the TOM-TIM23 supercomplex [0.03%]
线粒体前蛋白通过TOM-TIM23超复合物进口的分子途径
Xueyin Zhou,Yuqi Yang,Guopeng Wang et al.
Xueyin Zhou et al.
Over half of mitochondrial proteins are imported from the cytosol via the pre-sequence pathway, controlled by the TOM complex in the outer membrane and the TIM23 complex in the inner membrane. The mechanisms through which proteins are trans...
Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler [0.03%]
核小体密度决定了哺乳动物染色质重塑复合物的千碱基尺度调节作用
Nour J Abdulhay,Laura J Hsieh,Colin P McNally et al.
Nour J Abdulhay et al.
Nearly all essential nuclear processes act on DNA packaged into arrays of nucleosomes. However, our understanding of how these processes (for example, DNA replication, RNA transcription, chromatin extrusion and nucleosome remodeling) occur ...