Structural organization of the retriever-CCC endosomal recycling complex [0.03%]
捕鼠器-CCC胞内体回吞复合体的结构组织
Daniel J Boesch,Amika Singla,Yan Han et al.
Daniel J Boesch et al.
The recycling of membrane proteins from endosomes to the cell surface is vital for cell signaling and survival. Retriever, a trimeric complex of vacuolar protein-sorting-associated protein (VPS)35L, VPS26C and VPS29, together with the CCC c...
Frederik V Schmidt,Luca Schulz,Jan Zarzycki et al.
Frederik V Schmidt et al.
Nitrogenases are best known for catalyzing the reduction of dinitrogen to ammonia at a complex metallic cofactor. Recently, nitrogenases were shown to reduce carbon dioxide (CO2) and carbon monoxide to hydrocarbons, offering a pathway to re...
Complete set of the Atg8-E1-E2-E3 conjugation machinery forms an interaction web that mediates membrane shaping [0.03%]
完整的Atg8-E1-E2-E3共轭机器是一张相互作用的网络，调控膜重塑
Jahangir Md Alam,Tatsuro Maruyama,Daisuke Noshiro et al.
Jahangir Md Alam et al.
Atg8, a ubiquitin-like protein, is conjugated with phosphatidylethanolamine (PE) via Atg7 (E1), Atg3 (E2) and Atg12-Atg5-Atg16 (E3) enzymatic cascade and mediates autophagy. However, its molecular roles in autophagosome formation are still ...
Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter [0.03%]
人SGLT2-MAP17葡萄糖转运蛋白的转运和抑制机制
Masahiro Hiraizumi,Tomoya Akashi,Kouta Murasaki et al.
Masahiro Hiraizumi et al.
Sodium-glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption. SGLT2 inhibitors suppress renal glucose reabsorption, therefore reducing blood glucose levels in patients with type 2 diabetes. We and others have developed several...
Daniel B Haack,Boris Rudolfs,Cheng Zhang et al.
Daniel B Haack et al.
Branching is a critical step in RNA splicing that is essential for 5' splice site selection. Recent spliceosome structures have led to competing models for the recognition of the invariant adenosine at the branch point. However, there are n...
3D Enhancer-promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages [0.03%]
三维增强子-启动子网络提供基因表达及协同调节的预测特征早期胚胎细胞系中的基因表达及核心调控的三维增强子-启动子网络预测特征研究
Dylan Murphy,Eralda Salataj,Dafne Campigli Di Giammartino et al.
Dylan Murphy et al.
Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that give rise to three essential lineages: the trophectoderm, the epiblast and the primitive endoderm. Although key signaling pathways and transcription fact...
Shaon Basu,Paula Martínez-Cristóbal,Marta Frigolé-Vivas et al.
Shaon Basu et al.
Transcription factors are among the most attractive therapeutic targets but are considered largely 'undruggable' in part due to the intrinsically disordered nature of their activation domains. Here we show that the aromatic character of the...
The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts [0.03%]
可变剪接对蛋白质组功能的调控作用：重塑蛋白质相互作用网络以在新环境中赋予老蛋白新功能
Peter Kjer-Hansen,Robert J Weatheritt
Peter Kjer-Hansen
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a myriad of ways. Here, we review our understanding of the breadth of these changes from their effect on protein struct...