Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes [0.03%]
滑膜肉瘤X染色体断裂点1蛋白使用隐秘的沟壑来选择性地识别H2AK119Ub核小体
Zebin Tong,Huasong Ai,Ziyu Xu et al.
Zebin Tong et al.
The cancer-specific fusion oncoprotein SS18-SSX1 disturbs chromatin accessibility by hijacking the BAF complex from the promoters and enhancers to the Polycomb-repressed chromatin regions. This process relies on the selective recognition of...
Shu-Jing Han,Yong-Liang Jiang,Lin-Lin You et al.
Shu-Jing Han et al.
Transcription factors respond to multilevel stimuli and co-occupy promoter regions of target genes to activate RNA polymerase (RNAP) in a cooperative manner. To decipher the molecular mechanism, here we report two cryo-electron microscopy s...
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening [0.03%]
先驱因子Pax7启动两个步骤的细胞周期依赖性染色质开放过程
Arthur Gouhier,Justine Dumoulin-Gagnon,Vincent Lapointe-Roberge et al.
Arthur Gouhier et al.
Pioneer transcription factors direct cell differentiation by deploying new enhancer repertoires through their unique ability to target and initiate remodelling of closed chromatin. The initial steps of their action remain undefined, althoug...
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD [0.03%]
出版更正：活细胞三维单分子追踪技术揭示了NuRD对增强子动力学的调节作用
S Basu,O Shukron,D Hall et al.
S Basu et al.
Published Erratum
Nature structural & molecular biology. 2024 Feb;31(2):390. DOI:10.1038/s41594-023-01179-1 2024
The anticancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3' processing machinery [0.03%]
抗癌化合物JTE-607揭示了mRNA 3'端加工 Machinery的隐藏序列特异性
Liang Liu,Angela M Yu,Xiuye Wang et al.
Liang Liu et al.
JTE-607 is an anticancer and anti-inflammatory compound and its active form, compound 2, directly binds to and inhibits CPSF73, the endonuclease for the cleavage step in pre-messenger RNA (pre-mRNA) 3' processing. Surprisingly, compound 2-m...
Katarzyna Ciazynska
Katarzyna Ciazynska
Michal Wasilewski,Piotr Draczkowski,Agnieszka Chacinska
Michal Wasilewski
Talin and kindlin use integrin tail allostery and direct binding to activate integrins [0.03%]
整合素活化的双轨机制：talin和kindlin对整合素尾部变构及直接结合作用
Jonas Aretz,Masood Aziz,Nico Strohmeyer et al.
Jonas Aretz et al.
Integrin affinity regulation, also termed integrin activation, is essential for metazoan life. Although talin and kindlin binding to the β-integrin cytoplasmic tail is indispensable for integrin activation, it is unknown how they achieve t...