Iris Müller,Kristian Helin
Iris Müller
The human silencing hub (HUSH) complex is an epigenetic repressor complex whose role has emerged as an important guardian of genome integrity. It protects the genome from exogenous DNA invasion and regulates endogenous retroelements by recr...
Author Correction: Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex [0.03%]
作者更正：人tRNA剪接内切酶复合物识别和处理前-tRNA的结构基础
Cassandra K Hayne,Kevin John U Butay,Zachary D Stewart et al.
Cassandra K Hayne et al.
Published Erratum
Nature structural & molecular biology. 2024 Feb;31(2):390. DOI:10.1038/s41594-024-01213-w 2024
Xiaofeng Zhang,Xiechao Zhan,Tong Bian et al.
Xiaofeng Zhang et al.
Selection of the pre-mRNA branch site (BS) by the U2 small nuclear ribonucleoprotein (snRNP) is crucial to prespliceosome (A complex) assembly. The RNA helicase PRP5 proofreads BS selection but the underlying mechanism remains unclear. Here...
Mitotic bookmarking redundancy by nuclear receptors in pluripotent cells [0.03%]
多能细胞中核受体的有丝分裂书签冗余作用
Almira Chervova,Amandine Molliex,H Irem Baymaz et al.
Almira Chervova et al.
Mitotic bookmarking transcription factors (TFs) are thought to mediate rapid and accurate reactivation after mitotic gene silencing. However, the loss of individual bookmarking TFs often leads to the deregulation of only a small proportion ...
Kevin A DAmico,Abigail E Stanton,Jaden D Shirkey et al.
Kevin A DAmico et al.
Most membrane fusion reactions in eukaryotic cells are mediated by multisubunit tethering complexes (MTCs) and SNARE proteins. MTCs are much larger than SNAREs and are thought to mediate the initial attachment of two membranes. Complementar...
Andrea Musacchio
Andrea Musacchio
Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation [0.03%]
RAS棕榈酰转移酶的调节因子及棕榈酰化调节作用
Anlan Yang,Shengjie Liu,Yuqi Zhang et al.
Anlan Yang et al.
Palmitoylation of cysteine residues at the C-terminal hypervariable regions in human HRAS and NRAS, which is necessary for RAS signaling, is catalyzed by the acyltransferase DHHC9 in complex with its accessory protein GCP16. The molecular b...
The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer [0.03%]
表观遗传学疗法靶向内分泌抵抗性乳腺癌中三维表观基因组的潜力
Joanna Achinger-Kawecka,Clare Stirzaker,Neil Portman et al.
Joanna Achinger-Kawecka et al.
Three-dimensional (3D) epigenome remodeling is an important mechanism of gene deregulation in cancer. However, its potential as a target to counteract therapy resistance remains largely unaddressed. Here, we show that epigenetic therapy wit...
UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4 [0.03%]
UBR4通过非典型E3连接酶模块募集UBE2A和UBE2B
Lucy Barnsby-Greer,Peter D Mabbitt,Marc-Andre Dery et al.
Lucy Barnsby-Greer et al.
UBR4 is a 574 kDa E3 ligase (E3) of the N-degron pathway with roles in neurodevelopment, age-associated muscular atrophy and cancer. The catalytic module that carries out ubiquitin (Ub) transfer remains unknown. Here we identify and charact...
Lifei Li,Kangjing Chen,Youyang Sia et al.
Lifei Li et al.
Nucleosomes are basic repeating units of chromatin and form regularly spaced arrays in cells. Chromatin remodelers alter the positions of nucleosomes and are vital in regulating chromatin organization and gene expression. Here we report the...