Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution [0.03%]
单核苷酸分辨率下混合型聚（A）尾的脱腺苷过程动力学研究
Young-Suk Lee,Yevgen Levdansky,Yoonseok Jung et al.
Young-Suk Lee et al.
Shortening of messenger RNA poly(A) tails, or deadenylation, is a rate-limiting step in mRNA decay and is highly regulated during gene expression. The incorporation of non-adenosines in poly(A) tails, or 'mixed tailing', has been observed i...
Chemical rewiring of ubiquitination by degraders and their selectivity routes [0.03%]
降解剂及其选择性途径对泛素连接系统的化学改组
Rory Whelan,Cristina Mayor-Ruiz
Rory Whelan
Katarzyna Ciazynska
Katarzyna Ciazynska
Noboru Mizushima
Noboru Mizushima
Sanim Rahman,Cynthia Wolberger
Sanim Rahman
The discovery of ubiquitin conjugation to lysines and the role of K48-linked polyubiquitin in targeting substrates for proteasomal degradation was followed by revelation of non-degradative roles of ubiquitination and, more recently, of non-...
Protein-intrinsic properties and context-dependent effects regulate pioneer factor binding and function [0.03%]
蛋白质内在属性和环境依赖效应调节先锋因子的结合与功能
Tyler J Gibson,Elizabeth D Larson,Melissa M Harrison
Tyler J Gibson
Chromatin is a barrier to the binding of many transcription factors. By contrast, pioneer factors access nucleosomal targets and promote chromatin opening. Despite binding to target motifs in closed chromatin, many pioneer factors display c...
Author Correction: Structural basis of pH-dependent activation in a CLC transporter [0.03%]
作者更正：CLC转运蛋白pH依赖性激活的结构基础
Eva Fortea,Sangyun Lee,Rahul Chadda et al.
Eva Fortea et al.
Published Erratum
Nature structural & molecular biology. 2024 Apr;31(4):728. DOI:10.1038/s41594-024-01242-5 2024
Bernhard C Lechtenberg,David Komander
Bernhard C Lechtenberg
Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA [0.03%]
单核样结构揭示了线粒体DNA的异质包装结构
R Stefan Isaac,Thomas W Tullius,Katja G Hansen et al.
R Stefan Isaac et al.
Cellular metabolism relies on the regulation and maintenance of mitochondrial DNA (mtDNA). Hundreds to thousands of copies of mtDNA exist in each cell, yet because mitochondria lack histones or other machinery important for nuclear genome c...