Structure of the human KMN complex and implications for regulation of its assembly [0.03%]
人类KMN复合体的结构及其组装调控意义
Soumitra Polley,Tobias Raisch,Sabrina Ghetti et al.
Soumitra Polley et al.
Biorientation of chromosomes during cell division is necessary for precise dispatching of a mother cell's chromosomes into its two daughters. Kinetochores, large layered structures built on specialized chromosome loci named centromeres, pro...
Stanislau Yatskevich,Jing Yang,Dom Bellini et al.
Stanislau Yatskevich et al.
Faithful chromosome segregation requires robust, load-bearing attachments of chromosomes to the mitotic spindle, a function accomplished by large macromolecular complexes termed kinetochores. In most eukaryotes, the constitutive centromere-...
Nitika Gaurav,Akinori Kanai,Catherine Lachance et al.
Nitika Gaurav et al.
JADE is a core subunit of the HBO1 acetyltransferase complex that regulates developmental and epigenetic programs and promotes gene transcription. Here we describe the mechanism by which JADE facilitates recruitment of the HBO1 complex to c...
Ishika Luthra,Cassandra Jensen,Xinyi E Chen et al.
Ishika Luthra et al.
Genomes encode for genes and non-coding DNA, both capable of transcriptional activity. However, unlike canonical genes, many transcripts from non-coding DNA have limited evidence of conservation or function. Here, to determine how much biol...
Author Correction: Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation [0.03%]
作者更正：移位的PAMs产生DNA末端并增强SpCas9转座后复合物的解离
Jinglong Wang,Julien Le Gall,Richard L Frock et al.
Jinglong Wang et al.
Published Erratum
Nature structural & molecular biology. 2024 Mar;31(3):578. DOI:10.1038/s41594-024-01247-0 2024
Patrick Cramer
Patrick Cramer
Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition [0.03%]
结合核小体的NR5A2结构揭示了先驱因子通过DNA小沟锚点竞争的机制
Wataru Kobayashi,Anna H Sappler,Daniel Bollschweiler et al.
Wataru Kobayashi et al.
Gene expression during natural and induced reprogramming is controlled by pioneer transcription factors that initiate transcription from closed chromatin. Nr5a2 is a key pioneer factor that regulates zygotic genome activation in totipotent ...
The open gate of the AMPA receptor forms a Ca2+ binding site critical in regulating ion transport [0.03%]
AMPA受体的开放门结构形成一个调控离子转运的关键Ca2+结合位点
Terunaga Nakagawa,Xin-Tong Wang,Federico J Miguez-Cabello et al.
Terunaga Nakagawa et al.
Alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptors (AMPARs) are cation-selective ion channels that mediate most fast excitatory neurotransmission in the brain. Although their gating mechanism has been studied extensively, ...
Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis [0.03%]
人类鞘磷脂合成酶的冷冻电镜结构及其对鞘磷脂合成机制的意义
Kexin Hu,Qing Zhang,Yang Chen et al.
Kexin Hu et al.
Sphingomyelin (SM) has key roles in modulating mammalian membrane properties and serves as an important pool for bioactive molecules. SM biosynthesis is mediated by the sphingomyelin synthase (SMS) family, comprising SMS1, SMS2 and SMS-rela...
The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction [0.03%]
CNK-HYP脚手架复合体通过增强KSR-MEK相互作用来促进RAF激活
Pierre Maisonneuve,Malha Sahmi,Fanny Bergeron-Labrecque et al.
Pierre Maisonneuve et al.
The RAS-MAPK pathway regulates cell proliferation, differentiation and survival, and its dysregulation is associated with cancer development. The pathway minimally comprises the small GTPase RAS and the kinases RAF, MEK and ERK. Activation ...