Author Correction: Structure and interactions of the endogenous human Commander complex [0.03%]
作者更正：人类内源性Commander复合物的结构和相互作用
Saara Laulumaa,Esa-Pekka Kumpula,Juha T Huiskonen et al.
Saara Laulumaa et al.
Published Erratum
Nature structural & molecular biology. 2024 May;31(5):846. DOI:10.1038/s41594-024-01273-y 2024
The impact of DNA methylation on CTCF-mediated 3D genome organization [0.03%]
DNA甲基化对CTCF介导的三维基因组组织的影响
Ana Monteagudo-Sánchez,Daan Noordermeer,Maxim V C Greenberg
Ana Monteagudo-Sánchez
Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although the role of DNA methylation at gene promoters and repetitive elements has been extensively studied, the function of DNA methylation in other genomic cont...
A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α-primase [0.03%]
DNA聚合酶α-引物酶催化结构介导的引物合成的作用机制模型
Elwood A Mullins,Lauren E Salay,Clarissa L Durie et al.
Elwood A Mullins et al.
The mechanism by which polymerase α-primase (polα-primase) synthesizes chimeric RNA-DNA primers of defined length and composition, necessary for replication fidelity and genome stability, is unknown. Here, we report cryo-EM structures of ...
Mélody Merle,Leah Friedman,Corinne Chureau et al.
Mélody Merle et al.
Gene expression is inherently noisy, posing a challenge to understanding how precise and reproducible patterns of gene expression emerge in mammals. Here we investigate this phenomenon using gastruloids, a three-dimensional in vitro model f...
Author Correction: PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome [0.03%]
《PRESTO-Tango作为可公开获取的资源对人类GPCR组进行研究》修正
Wesley K Kroeze,Maria F Sassano,Xi-Ping Huang et al.
Wesley K Kroeze et al.
Published Erratum
Nature structural & molecular biology. 2024 Mar;31(3):578. DOI:10.1038/s41594-023-01129-x 2024
Cheryl H Arrowsmith
Cheryl H Arrowsmith
Sarah Schneider,Irina Brandina,Daniel Peter et al.
Sarah Schneider et al.
The 20S U5 small nuclear ribonucleoprotein particle (snRNP) is a 17-subunit RNA-protein complex and a precursor of the U4/U6.U5 tri-snRNP, the major building block of the precatalytic spliceosome. CD2BP2 is a hallmark protein of the 20S U5 ...
Daria Riabov Bassat,Supapat Visanpattanasin,Matthias K Vorländer et al.
Daria Riabov Bassat et al.
Pre-mRNA splicing by the spliceosome requires the biogenesis and recycling of its small nuclear ribonucleoprotein (snRNP) complexes, which are consumed in each round of splicing. The human U5 snRNP is the ~1 MDa 'heart' of the spliceosome a...
Structure and interactions of the endogenous human Commander complex [0.03%]
人类内源性Commander复合体的结构与相互作用
Saara Laulumaa,Esa-Pekka Kumpula,Juha T Huiskonen et al.
Saara Laulumaa et al.
The Commander complex, a 16-protein assembly, plays multiple roles in cell homeostasis, cell cycle and immune response. It consists of copper-metabolism Murr1 domain proteins (COMMD1-10), coiled-coil domain-containing proteins (CCDC22 and C...