Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ [0.03%]
Gβγ激活磷脂酶3激酶γ的分子机制
Chun-Liang Chen,Ramizah Syahirah,Sandeep K Ravala et al.
Chun-Liang Chen et al.
The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-kinase γ (PI3Kγ) is critical for neutrophil chemotaxis and cancer metastasis. PI3Kγ is activated by Gβγ heterodime...
Nicola J Smith,Fiona Murray
Nicola J Smith
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome [0.03%]
唐氏综合症患者大脑中淀粉样蛋白和tau原纤维的低温电子显微镜结构
Anllely Fernandez,Md Rejaul Hoq,Grace I Hallinan et al.
Anllely Fernandez et al.
Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS and AD regarding the structure of amyloid-β (Aβ) and tau filaments is unknown. Here we report the structure of Aβ an...
Lily Yeh Jan,Yuh Nung Jan
Lily Yeh Jan
An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality [0.03%]
一个寡肽渗透酶OppABCD的功能需要一个铁硫簇结构域
Xiaolin Yang,Tianyu Hu,Jingxi Liang et al.
Xiaolin Yang et al.
Oligopeptide permease, OppABCD, belongs to the type I ABC transporter family. Its role is to import oligopeptides into bacteria for nutrient uptake and to modulate the host immune response. OppABCD consists of a cluster C substrate-binding ...
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine [0.03%]
lysidine和agmatidine修饰的异亮氨酸tRNA的解码能力的新见解
Naho Akiyama,Kensuke Ishiguro,Takeshi Yokoyama et al.
Naho Akiyama et al.
The anticodon modifications of transfer RNAs (tRNAs) finetune the codon recognition on the ribosome for accurate translation. Bacteria and archaea utilize the modified cytidines, lysidine (L) and agmatidine (agm2C), respectively, in the ant...
Structures of the ribosome bound to EF-Tu-isoleucine tRNA elucidate the mechanism of AUG avoidance [0.03%]
核糖体结合EF-Tu-异亮氨酸tRNA的结构阐明了AUG避免机制
Mariia Yu Rybak,Matthieu G Gagnon
Mariia Yu Rybak
The frequency of errors upon decoding of messenger RNA by the bacterial ribosome is low, with one misreading event per 1 × 104 codons. In the universal genetic code, the AUN codon box specifies two amino acids, isoleucine and methionine. I...
Molecular stripping underpins derepression of a toxin-antitoxin system [0.03%]
分子剥离机制解除毒蛋白-抗毒蛋白系统的抑制状态
Grzegorz J Grabe,Rachel T Giorgio,Miłosz Wieczór et al.
Grzegorz J Grabe et al.
Transcription factors control gene expression; among these, transcriptional repressors must liberate the promoter for derepression to occur. Toxin-antitoxin (TA) modules are bacterial elements that autoregulate their transcription by bindin...
Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1 [0.03%]
RYBP-PRC1组蛋白泛素修饰阅读-书写机制的结构基础
Maria Ciapponi,Elena Karlukova,Sven Schkölziger et al.
Maria Ciapponi et al.
Histone H2A monoubiquitination (H2Aub1) by the PRC1 subunit RING1B entails a positive feedback loop, mediated by the RING1B-interacting protein RYBP. We uncover that human RYBP-PRC1 binds unmodified nucleosomes via RING1B but H2Aub1-modifie...