Structure of the native γ-tubulin ring complex capping spindle microtubules [0.03%]
原生γ-微管蛋白环复合物的结构及其对纺锤体微管的封端作用
Tom Dendooven,Stanislau Yatskevich,Alister Burt et al.
Tom Dendooven et al.
Microtubule (MT) filaments, composed of α/β-tubulin dimers, are fundamental to cellular architecture, function and organismal development. They are nucleated from MT organizing centers by the evolutionarily conserved γ-tubulin ring compl...
Amol Aher,Linas Urnavicius,Allen Xue et al.
Amol Aher et al.
Microtubules are composed of α-tubulin and β-tubulin dimers positioned head-to-tail to form protofilaments that associate laterally in varying numbers. It is not known how cellular microtubules assemble with the canonical 13-protofilament...
Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex [0.03%]
由CUL9 E3连接酶复合物介导的非经典组装、泛素化和嵌合性cullin-RING/RBR连接酶的机制研究
Daniel Horn-Ghetko,Linus V M Hopf,Ishita Tripathi-Giesgen et al.
Daniel Horn-Ghetko et al.
Ubiquitin ligation is typically executed by hallmark E3 catalytic domains. Two such domains, 'cullin-RING' and 'RBR', are individually found in several hundred human E3 ligases, and collaborate with E2 enzymes to catalyze ubiquitylation. Ho...
Visualizing chaperone-mediated multistep assembly of the human 20S proteasome [0.03%]
人源20S蛋白酶体分子伴侣介导的多步组装过程可视化研究
Frank Adolf,Jiale Du,Ellen A Goodall et al.
Frank Adolf et al.
Dedicated assembly factors orchestrate the stepwise production of many molecular machines, including the 28-subunit proteasome core particle (CP) that mediates protein degradation. Here we report cryo-electron microscopy reconstructions of ...
Benjamin Velez,Richard M Walsh Jr,Shaun Rawson et al.
Benjamin Velez et al.
Many large molecular machines are too elaborate to assemble spontaneously and are built through ordered pathways orchestrated by dedicated chaperones. During assembly of the core particle (CP) of the proteasome, where protein degradation oc...
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia [0.03%]
腺苷酸环化酶5与Gβγ复合物的结构为ADCY5相关运动障碍提供新见解
Yu-Chen Yen,Yong Li,Chun-Liang Chen et al.
Yu-Chen Yen et al.
The nine different membrane-anchored adenylyl cyclase isoforms (AC1-9) in mammals are stimulated by the heterotrimeric G protein, Gαs, but their response to Gβγ regulation is isoform specific. In the present study, we report cryo-electro...
Transport mechanism of presynaptic high-affinity choline uptake by CHT1 [0.03%]
胆碱高亲和力转运机制由胆碱转运蛋白1完成
Yunlong Qiu,Yiwei Gao,Bo Huang et al.
Yunlong Qiu et al.
Choline is a vital nutrient and a precursor for the biosynthesis of essential metabolites, including acetylcholine (ACh), that play a central role in fetal development, especially in the brain. In cholinergic neurons, the high-affinity chol...
Author Correction: Structural basis for partial agonism in 5-HT3A receptors [0.03%]
作者更正：5-ht3a受体偏拮抗作用的结构基础
Kevin Felt,Madeleine Stauffer,Leslie Salas-Estrada et al.
Kevin Felt et al.
Published Erratum
Nature structural & molecular biology. 2024 Apr;31(4):728. DOI:10.1038/s41594-024-01306-6 2024
Irene Vercellino,Leonid A Sazanov
Irene Vercellino
Supercomplexes of the respiratory chain are established constituents of the oxidative phosphorylation system, but their role in mammalian metabolism has been hotly debated. Although recent studies have shown that different tissues/organs ar...
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss [0.03%]
一种罕见遗传变异偏向于偏移孕妇减数分裂倾向流产风险
Sara A Carioscia,Rajiv C McCoy
Sara A Carioscia