Transcription directionality is licensed by Integrator at active human promoters [0.03%]
整合子在活性人源启动子上授权转录方向性
Jiao Yang,Jingyang Li,Langxi Miao et al.
Jiao Yang et al.
A universal characteristic of eukaryotic transcription is that the promoter recruits RNA polymerase II (RNAPII) to produce both precursor mRNAs (pre-mRNAs) and short unstable promoter upstream transcripts (PROMPTs) toward the opposite direc...
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation [0.03%]
TOPORS和RNF4的协同SUMO靶向泛素连接酶活性对压力管理及细胞增殖至关重要
Julio C Y Liu,Leena Ackermann,Saskia Hoffmann et al.
Julio C Y Liu et al.
Protein SUMOylation provides a principal driving force for cellular stress responses, including DNA-protein crosslink (DPC) repair and arsenic-induced PML body degradation. In this study, using genome-scale screens, we identified the human ...
Simon Newstead
Simon Newstead
Solute carriers (SLCs) control the flow of small molecules and ions across biological membranes. Over the last 20 years, the pace of research in SLC biology has accelerated markedly, opening new opportunities to treat metabolic diseases, ca...
Author Correction: RNA polymerase II pausing regulates chromatin organization in erythrocytes [0.03%]
作者更正：RNA聚合酶II暂停调节红细胞染色质组织
Andrés Penagos-Puig,Sherlyn Claudio-Galeana,Aura Stephenson-Gussinye et al.
Andrés Penagos-Puig et al.
Published Erratum
Nature structural & molecular biology. 2024 May;31(5):846. DOI:10.1038/s41594-024-01307-5 2024
Vimentin filaments integrate low-complexity domains in a complex helical structure [0.03%]
角蛋白 filament 通过复杂螺旋结构整合低复杂度区域
Matthias Eibauer,Miriam S Weber,Rafael Kronenberg-Tenga et al.
Matthias Eibauer et al.
Intermediate filaments (IFs) are integral components of the cytoskeleton. They provide cells with tissue-specific mechanical properties and are involved in numerous cellular processes. Due to their intricate architecture, a 3D structure of ...
HS-AFM single-molecule structural biology uncovers basis of transporter wanderlust kinetics [0.03%]
基于HS-AFM的单分子结构生物学揭示了转运蛋白的游移动力学机制
Yining Jiang,Atsushi Miyagi,Xiaoyu Wang et al.
Yining Jiang et al.
The Pyrococcus horikoshii amino acid transporter GltPh revealed, like other channels and transporters, activity mode switching, previously termed wanderlust kinetics. Unfortunately, to date, the basis of these activity fluctuations is not u...
DNA double-strand break-capturing nuclear envelope tubules drive DNA repair [0.03%]
捕获DNA双链断裂的核膜小管驱动DNA修复
Mitra Shokrollahi,Mia Stanic,Anisha Hundal et al.
Mitra Shokrollahi et al.
Current models suggest that DNA double-strand breaks (DSBs) can move to the nuclear periphery for repair. It is unclear to what extent human DSBs display such repositioning. Here we show that the human nuclear envelope localizes to DSBs in ...
Xiao-Yuan Yang,Zhangfei Shen,Jiale Xie et al.
Xiao-Yuan Yang et al.
As one of the most prevalent anti-phage defense systems in prokaryotes, Gabija consists of a Gabija protein A (GajA) and a Gabija protein B (GajB). The assembly and function of the Gabija system remain unclear. Here we present cryo-EM struc...