Structural basis of TRPV1 modulation by endogenous bioactive lipids [0.03%]
内源生物活性脂质介导的TRPV1通道调制机制及其结构基础
William R Arnold,Adamo Mancino,Frank R Moss rd et al.
William R Arnold et al.
TRP ion channels are modulated by phosphoinositide lipids, but the underlying structural mechanisms remain unclear. The capsaicin- and heat-activated receptor, TRPV1, has served as a model for deciphering lipid modulation, which is relevant...
Unveiling the secrets of vimentin filament architecture relevant to human disease [0.03%]
揭示与人类疾病相关的波形蛋白丝结构的秘密
Ivan B Lomakin,Minh Ho,Christopher G Bunick
Ivan B Lomakin
Structural basis of closed groove scrambling by a TMEM16 protein [0.03%]
TMEM16家族蛋白闭沟回文 scramblase 结构机制研究
Zhang Feng,Omar E Alvarenga,Alessio Accardi
Zhang Feng
Activation of Ca2+-dependent TMEM16 scramblases induces phosphatidylserine externalization, a key step in multiple signaling processes. Current models suggest that the TMEM16s scramble lipids by deforming the membrane near a hydrophilic gro...
Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins [0.03%]
由逆转录病毒衍生的人类蛋白的受体识别和抗病毒机制
Shashank Khare,Miryam I Villalba,Juan C Canul-Tec et al.
Shashank Khare et al.
Human syncytin-1 and suppressyn are cellular proteins of retroviral origin involved in cell-cell fusion events to establish the maternal-fetal interface in the placenta. In cell culture, they restrict infections from members of the largest ...
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity [0.03%]
单细胞中个体CpG二元体和转录组中5mC和5hmC的组合量化揭示了DNA甲基化维持保真度的调节因子
Alex Chialastri,Saumya Sarkar,Elizabeth E Schauer et al.
Alex Chialastri et al.
Inheritance of 5-methylcytosine from one cell generation to the next by DNA methyltransferase 1 (DNMT1) plays a key role in regulating cellular identity. While recent work has shown that the activity of DNMT1 is imprecise, it remains unclea...
Petra Vizjak,Dieter Kamp,Nicola Hepp et al.
Petra Vizjak et al.
How chromatin enzymes work in condensed chromatin and how they maintain diffusional mobility inside remains unexplored. Here we investigated these challenges using the Drosophila ISWI remodeling ATPase, which slides nucleosomes along DNA. F...
Structural insights into double-stranded RNA recognition and transport by SID-1 [0.03%]
SID-1识别并运输双链RNA的结构洞察
Jiangtao Zhang,Chunhua Zhan,Junping Fan et al.
Jiangtao Zhang et al.
RNA uptake by cells is critical for RNA-mediated gene interference (RNAi) and RNA-based therapeutics. In Caenorhabditis elegans, RNAi is systemic as a result of SID-1-mediated double-stranded RNA (dsRNA) across cells. Despite the functional...
Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing [0.03%]
哺乳动物PIWI-piRNA-靶标复合物揭示了广泛而高效的靶标沉默特征
Zhiqing Li,Zhenzhen Li,Yuqi Zhang et al.
Zhiqing Li et al.
The PIWI-interacting RNA (piRNA) pathway is an adaptive defense system wherein piRNAs guide PIWI family Argonaute proteins to recognize and silence ever-evolving selfish genetic elements and ensure genome integrity. Driven by this intensive...
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos [0.03%]
由LincGET引导的paracompartment通过可变剪辑调节CARM1偏向哺乳动物早期胚胎中第一个细胞命运
Jiaqiang Wang,Yiwei Zhang,Jiaze Gao et al.
Jiaqiang Wang et al.
The heterogeneity of CARM1 controls first cell fate bias during early mouse development. However, how this heterogeneity is established is unknown. Here, we show that Carm1 mRNA is of a variety of specific exon-skipping splicing (ESS) isofo...