Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution [0.03%]
古TRPM通道酶的酶活性和门控偶联及其分子进化
Yihe Huang,Sushant Kumar,Junuk Lee et al.
Yihe Huang et al.
Channel enzymes represent a class of ion channels with enzymatic activity directly or indirectly linked to their channel function. We investigated a TRPM2 chanzyme from choanoflagellates that integrates two seemingly incompatible functions ...
eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition [0.03%]
eIF4A1增强mTORC1抑制过程中的LARP1介导的翻译抑制作用
Yuichi Shichino,Tomokazu Yamaguchi,Kazuhiro Kashiwagi et al.
Yuichi Shichino et al.
Eukaryotic translation initiation factor (eIF)4A-a DEAD-box RNA-binding protein-plays an essential role in translation initiation. Recent reports have suggested helicase-dependent and helicase-independent functions for eIF4A, but the multif...
To slide or not to slide: key role of the hexasome in chromatin remodeling revealed [0.03%]
滑或不滑：六聚体在染色质重塑中发挥关键作用
Daniela Rhodes
Daniela Rhodes
Hexasomes are non-canonical nucleosomes that package DNA with six instead of eight histones. First discovered 40 years ago as a consequence of transcription, two near-atomic-resolution cryo-EM structures of the hexasome in complex with the ...
RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth [0.03%]
RNA干扰筛选鉴定出HES4是调节支持嘧啶合成和肿瘤生长的氧化还原平衡的调控因子
Jing He,Aoxue Wang,Qin Zhao et al.
Jing He et al.
NADH/NAD+ redox balance is pivotal for cellular metabolism. Systematic identification of NAD(H) redox regulators, although currently lacking, would help uncover unknown effectors critically implicated in the coordination of growth metabolis...
Structure and mechanism of lysosome transmembrane acetylation by HGSNAT [0.03%]
HGSNAT介导的溶酶体跨膜乙酰化的作用方式和机制研究
Ruisheng Xu,Yingjie Ning,Fandong Ren et al.
Ruisheng Xu et al.
Lysosomal transmembrane acetylation of heparan sulfates (HS) is catalyzed by HS acetyl-CoA:α-glucosaminide N-acetyltransferase (HGSNAT), whose dysfunction leads to lysosomal storage diseases. The mechanism by which HGSNAT, the sole non-hyd...
Sarah S Henrikus,Marta H Gross,Oliver Willhoft et al.
Sarah S Henrikus et al.
To prevent detrimental chromosome re-replication, DNA loading of a double hexamer of the minichromosome maintenance (MCM) replicative helicase is temporally separated from DNA unwinding. Upon S-phase transition in yeast, DNA unwinding is ac...
The LexA-RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation [0.03%]
LexA-RecA* 结构揭示了触发SOS反应的隐秘锁钥机制
Michael B Cory,Allen Li,Christina M Hurley et al.
Michael B Cory et al.
The bacterial SOS response plays a key role in adaptation to DNA damage, including genomic stress caused by antibiotics. SOS induction begins when activated RecA*, an oligomeric nucleoprotein filament that forms on single-stranded DNA, bind...
Lori A Passmore,Suyang Zhang
Lori A Passmore