Eva Nogales
Eva Nogales
Ramanujan S Hegde,Robert J Keenan
Ramanujan S Hegde
α-Helical integral membrane proteins comprise approximately 25% of the proteome in all organisms. The membrane proteome is highly diverse, varying in the number, topology, spacing and properties of transmembrane domains. This diversity imp...
Junjiao Yang,Chan-I Chung,Jessica Koach et al.
Junjiao Yang et al.
Dysregulation and enhanced expression of MYC transcription factors (TFs) including MYC and MYCN contribute to the majority of human cancers. For example, MYCN is amplified up to several hundredfold in high-risk neuroblastoma. The resulting ...
XPD stalled on cross-linked DNA provides insight into damage verification [0.03%]
XP双链DNA损伤位点停滞提供了验证损伤的见解
Jochen Kuper,Tamsanqa Hove,Sarah Maidl et al.
Jochen Kuper et al.
The superfamily 2 helicase XPD is a central component of the general transcription factor II H (TFIIH), which is essential for transcription and nucleotide excision DNA repair (NER). Within these two processes, the helicase function of XPD ...
Yingxia Hu,Krista A Delviks-Frankenberry,Chunxiang Wu et al.
Yingxia Hu et al.
HIV-1 Vif recruits host cullin-RING-E3 ubiquitin ligase and CBFβ to degrade the cellular APOBEC3 antiviral proteins through diverse interactions. Recent evidence has shown that Vif also degrades the regulatory subunits PPP2R5(A-E) of cellu...
Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification [0.03%]
Tead4和Tfap2c在合子基因组激活期间产生双潜能并建立一个双稳态开关以促进谱系多样化
Meng Zhu,Maciej Meglicki,Adiyant Lamba et al.
Meng Zhu et al.
The mouse and human embryo gradually loses totipotency before diversifying into the inner cell mass (ICM, future organism) and trophectoderm (TE, future placenta). The transcription factors TFAP2C and TEAD4 with activated RHOA accelerate em...
Chad S Driscoll,Jaehwan Kim,Jason G Knott
Chad S Driscoll
Natalya Leneva,Oleksiy Kovtun
Natalya Leneva
Maximilian Stötzel,Chieh-Yu Cheng,Ibrahim A IIik et al.
Maximilian Stötzel et al.
Dormancy is an essential biological process for the propagation of many life forms through generations and stressful conditions. Early embryos of many mammals are preservable for weeks to months within the uterus in a dormant state called d...